Gender Difference of Circulating Ghrelin and Leptin Concentrations in Chronic <i>Helicobacter pylori</i> Infection

Chuang, Chiao‐Hsiung; Sheu, Bor–Shyang; Yang, Hsiao Bai; Lee, Shui Cheng; Kao, Ai Wen; Cheng, Hsiu–Chi; Chang, Wei-Lun; Yao, Wei‐Jen

doi:10.1111/j.1523-5378.2009.00653.x

Cited by 33 publications

(35 citation statements)

References 32 publications

(63 reference statements)

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“…However, unlike our result, they found the fasting Ghrelin level to be negatively related to the BMI, to be similar in males and females and not change with the menopausal status (15 Among patients positive for HP, the plasma Ghrelin levels were found to be lower in males. In addition, a strong correlation was found between HP infection and acute and chronic inflammation scores associated with it and lower Ghrelin levels but only in males (17). Our chromogranin-A immunohistochemical analysis performed to evaluate the distribution of endocrine cells in LSG resection material revealed a mild increase in endocrine cells in 13 patients (39.4%), focal simple hyperplasia in 3 patients (9.1%), simple hyperplasia in 7 patients (21.2%) and micronodular hyperplasia in 3 patients (9.1%).…”

Section: Discussionmentioning

confidence: 89%

Gastric histopathological findings and ghrelin expression in morbid obesity

Gündoğan¹,

Demirkan²,

Tekin³

et al. 2013

TJPATH

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Section: Discussionmentioning

confidence: 89%

Gastric histopathological findings and ghrelin expression in morbid obesity

Gündoğan¹,

Demirkan²,

Tekin³

et al. 2013

TJPATH

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“…In general, although H. pylori infection down-regulated plasma and gastric ghrelin levels in subjects with normal renal function[28-30], these results also demonstrate the possibility that not only long-standing enhanced gastric mucosal inflammation induced by H. pylori infection but also gastric mucosal atrophy influenced plasma and gastric mucosal acyl- and desacyl-ghrelin levels[18]. In fact, in subjects with normal renal function, plasma ghrelin level was lower in H. pylori -positive patients with severe mucosal atrophy than in those without[18].…”

Section: Discussionmentioning

confidence: 99%

Relationship between ghrelin,Helicobacter pyloriand gastric mucosal atrophy in hemodialysis patients

Ichikawa¹,

Sugimoto²,

Sakao³

et al. 2016

WJG

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AIMTo investigate the relationship between plasma ghrelin level, Helicobacter pylori (H. pylori) infection status and the severity of atrophy in hemodialysis patients.METHODSOne hundred eights patients who received hemodialysis and 13 non-hemodialysis H. pylori-negative controls underwent gastroduodenoscopy to evaluate the severity of gastric atrophy. Serum levels of pepsinogen (PG) were measured as serum markers of gastric atrophy. H. pylori infection was evaluated by anti-H. pylori IgG antibody, rapid urease test and culture test. We classified H. pylori infection status as non-infection, present infection and past infection. In addition, plasma acyl-ghrelin and desacyl-ghrelin levels were measured by enzyme-linked immunosorbent assay.RESULTSInfection rate of H. pylori was 45.4% (49/108). Acyl-ghrelin level in the non-infection group (39.4 ± 23.0 fmol/mL) was significantly higher than in the past (23.4 ± 19.9 fmol/mL, P = 0.005) and present infection groups (19.5 ± 14.0 fmol/mL, P < 0.001). Furthermore, desacyl-ghrelin level in the non-infection group (353.2 ± 190.2 fmol/mL) was significantly higher than those in the past (234.9 ± 137.5 fmol/mL, P = 0.008) and present infection groups (211.8 ± 124.2 fmol/mL, P < 0.001). Acyl-ghrelin was positively correlated with the PG I level and PG I/II ratio (|R| = 0.484, P < 0.001 and |R| = 0.403, P < 0.001, respectively). Both ghrelins were significantly decreased in accordance with the progress of endoscopic atrophy (both P < 0.001) and acyl-ghrelin was significantly lower in patients with mild, moderate and severe atrophy (24.5 ± 23.1 fmol/mL, 20.2 ± 14.9 fmol/mL and 18.3 ± 11.8 fmol/mL) than in those with non-atrophy (39.4 ± 22.2 fmol/mL, P = 0.039, P = 0.002 and P < 0.001, respectively).CONCLUSIONIn hemodialysis patients, plasma ghrelin level was associated with the endoscopic and serological severity of atrophy related to H. pylori infection.

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“…Some authors claim that the level of circulating ghrelin is higher in women than in men [19] , but others maintain that it is similar in both sexes [20] and does not vary from childhood to adulthood [21] or undergo an age-related decrease [22] . In our studies we clearly demonstrated that in the case of gastric ghrelin, the hormone level was much higher in pre-menopausal women than in men (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

Gastric ghrelin in relation to gender, stomach topographyand Helicobacter pylori in dyspeptic patients

Stec−Michalska¹,

Malicki²,

Michalski³

et al. 2009

WJG

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AIM:To investigate the level of gastric ghrelin in stomach mucosa of dyspeptic patients in relation to Helicobacter pylori (H pylori ) infection, bacterial cytotoxicity, topography and gender. METHODS:The study comprised 40 premenopausal women (19 H pylori positive) and 48 men (17 H pylori positive) with functional dyspepsia. All gastric biopsy specimens revealed normal mucosa or non-atrophic gastritis. Gastric ghrelin concentration was determined by Enzyme linked immunosorbent assay. The cagA and vacA strains of bacterial DNA were identified by multiplex polymerase chain reaction. RESULTS:In general, infection with H pylori caused an increase in gastric ghrelin level regardless of gender and stomach topography. Significantly more hormone was present in both, non-infected and H pylori positive female samples, as compared to males. The distribution of bacterial strains showed cagA (+) vacA s1m1 and cagA (-) vacA s2m2 genotypes as the most common infections in the studied population. A tendency to higher ghrelin levels was observed in less cytotoxic (cagA negative) strain-containing specimens from the antrum and corpus of both gender groups (without statistical significance). CONCLUSION: An increase in gastric ghrelin levelsat the stage of non-atrophic gastritis in H pylori positive patients, especially in those infected with cagA (-) strains, can exert a gastroprotective effect.

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Gender Difference of Circulating Ghrelin and Leptin Concentrations in Chronic Helicobacter pylori Infection

Abstract: There should be a gender difference to circulating total ghrelin levels, but not leptin levels, in response to H. pylori infection and its related chronic gastritis.

Cited by 33 publications

References 32 publications

Gastric histopathological findings and ghrelin expression in morbid obesity

Gastric histopathological findings and ghrelin expression in morbid obesity

Relationship between ghrelin,Helicobacter pyloriand gastric mucosal atrophy in hemodialysis patients

Gastric ghrelin in relation to gender, stomach topographyand Helicobacter pylori in dyspeptic patients

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