Gender Differences in Hypertension and Kidney Disease

Reyes, Daisy Verduzco; Lew, Susie Q.; Kimmel, Paul L.

doi:10.1016/j.mcna.2004.11.010

Cited by 39 publications

(39 citation statements)

References 88 publications

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“…Estrogens may upregulate production of such vasorelaxant substances as nitric oxide, react directly on vascular smooth muscle cells, and dampen the cardiovascular stress response to adrenergic stimuli. [17][18][19] Conversely, testosterone was shown to increase secretion of such vasoconstrictors as endothelin and stimulates the renin-angiotensin-aldosterone system, leading to inadequate sodium excretion in the setting of increased arterial blood pressure. 18,19 Genetic variability related to the renin-angiotensin-aldosterone system and/or the α-adrenergic receptor also was linked in population-based studies to sex differences in blood pressure in both African Americans 20 and whites.…”

Section: Discussionmentioning

confidence: 99%

“…[17][18][19] Conversely, testosterone was shown to increase secretion of such vasoconstrictors as endothelin and stimulates the renin-angiotensin-aldosterone system, leading to inadequate sodium excretion in the setting of increased arterial blood pressure. 18,19 Genetic variability related to the renin-angiotensin-aldosterone system and/or the α-adrenergic receptor also was linked in population-based studies to sex differences in blood pressure in both African Americans 20 and whites. 21 However, a primary biological explanation for sex differences in hypertension control would suggest persistently increased blood pressures for both African American and white men relative to women.…”

Section: Discussionmentioning

confidence: 99%

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Race and Sex Differences in Hypertension Control in CKD: Results From the Kidney Early Evaluation Program (KEEP)

Duru¹,

Li²,

Jurkovitz

et al. 2008

American Journal of Kidney Diseases

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Race and Sex Differences in Hypertension Control in CKD: Results From the Kidney Early Evaluation Program (KEEP)

Duru¹,

Li²,

Jurkovitz

et al. 2008

American Journal of Kidney Diseases

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“…Так, данные популяционного исследования, основан-ные на сравнительном анализе 4975 больных подагрой мужчин и 1158 женщин, показали, что средний возраст мужчин был на 12 лет меньше, при этом АГ у женщин вы-являлась в 1,42 раза чаще, а диуретики они принимали в 1,92 раза чаще, чем мужчины [8]. Известно, что женщи-ны живут дольше и распространенность АГ с возрастом у них также выше [11], а диуретики входят в число наибо-лее часто принимаемых гипотензивных препаратов [12]. Однако имеет ли основное значение в половых различиях фактор возраста -остается не ясным.…”

Section: результатыunclassified

Risk factors for gout: Gender differences

Eliseyev¹,

Chikalenkova²,

Денисов³

et al. 2011

rsp

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“…Sex dissimilarities in the progression of various renal diseases have been reported in animal and humans studies, with men at higher risk of developing renal diseases, with the tendency to develop it earlier in life and with a faster progression and deterioration of renal function than in women (22,23,27,33,51,54). Apart from the genetically coded dissimilarities between the sexes in renal structure and function, sex hormones may affect several of the routes implicated in the pathogenesis of renal disease development.…”

Section: Discussionmentioning

confidence: 99%

Effects of moderate global maternal nutrient reduction on fetal baboon renal mitochondrial gene expression at 0.9 gestation

Pereira

Oliveira

Tavares

et al. 2015

American Journal of Physiology-Renal Physiology

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Pereira SP, Oliveira PJ, Tavares LC, Moreno AJ, Cox LA, Nathanielsz PW, Nijland MJ. Effects of moderate global maternal nutrient reduction on fetal baboon renal mitochondrial gene expression at 0.9 gestation. Am J Physiol Renal Physiol 308: F1217-F1228, 2015. First published March 11, 2015 doi:10.1152/ajprenal.00419.2014.-Early life malnutrition results in structural alterations in the kidney, predisposing offspring to later life renal dysfunction. Kidneys of adults who were growth restricted at birth have substantial variations in nephron endowment. Animal models have indicated renal structural and functional consequences in offspring exposed to suboptimal intrauterine nutrition. Mitochondrial bioenergetics play a key role in renal energy metabolism, growth, and function. We hypothesized that moderate maternal nutrient reduction (MNR) would adversely impact fetal renal mitochondrial expression in a well-established nonhuman primate model that produces intrauterine growth reduction at term. Female baboons were fed normal chow diet or 70% of control diet (MNR). Fetal kidneys were harvested at cesarean section at 0.9 gestation (165 days gestation). Human Mitochondrial Energy Metabolism and Human Mitochondria Pathway PCR Arrays were used to analyze mitochondrially relevant mRNA expression. In situ protein content was detected by immunohistochemistry. Despite the smaller overall size, the fetal kidney weight-to-body weight ratio was not affected. We demonstrated fetal sex-specific differential mRNA expression encoding mitochondrial metabolite transport and dynamics proteins. MNRrelated differential gene expression was more evident in female fetuses, with 16 transcripts significantly altered, including 14 downregulated and 2 upregulated transcripts. MNR impacted 10 transcripts in male fetuses, with 7 downregulated and 3 upregulated transcripts. The alteration in mRNA levels was accompanied by a decrease in mitochondrial protein cytochrome c oxidase subunit VIc. In conclusion, transcripts encoding fetal renal mitochondrial energy metabolism proteins are nutrition sensitive in a sex-dependent manner. We speculate that these differences lead to decreased mitochondrial fitness that contributes to renal dysfunction in later life. mitochondria; kidney; fetal programming; nonhuman primate; gene expression SUBOPTIMAL PRENATAL DEVELOPMENT predisposes to adult onset diseases such as hypertension, diabetes, cardiovascular, and renal disease (2,9,42,64). Importantly, there is clear evidence that the developing nonhuman primate kidney is sensitive to decreased maternal nutrition (45). Poor intrauterine nutrition is associated with reduced nephron number in both animals and humans (29,35,41,62). Analysis of renal autopsies of adults born with low birth weight has shown substantial variations in renal composition (26). Remarkably, little attention has been given to the possible involvement of mitochondria as putative mediators between maternal nutrient reduction (MNR) and altered renal development in their offspring. This is surpr...

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Gender Differences in Hypertension and Kidney Disease

Cited by 39 publications

References 88 publications

Race and Sex Differences in Hypertension Control in CKD: Results From the Kidney Early Evaluation Program (KEEP)

Race and Sex Differences in Hypertension Control in CKD: Results From the Kidney Early Evaluation Program (KEEP)

Risk factors for gout: Gender differences

Effects of moderate global maternal nutrient reduction on fetal baboon renal mitochondrial gene expression at 0.9 gestation

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