Gender differences in ischemic stroke intra-hospital mortality: a systematic review

Abstract

The aim was to evaluate whether intra-hospital mortality from ischemic stroke is different in female patients. Methods. Studies were found in PubMed, Web of Science. We excluded 119 records because they did not include relevant reports or data. Studies were eligible for inclusion if enrolled adult patients with ischemic stroke and if the odds ratio (OR) of intra-hospital mortality in females compared to males is provided. Three retrospective cohort studies were eligible for inclusion criteria and so were included in the analysis. Findings: the random effect model showed a pooled significant higher risk of intra-hospital mortality [OR 1.34 (95% confidence interval 1.04, 1.74), P=0.026] in the female group compared to the male group. Our systematic review shows that intra-hospital mortality was significantly higher in female subjects compared to male.

|Therapeutic and preventive effects of apigenin in cerebral ischemia: a review

“…6,7 The significant changes of estrogen before and after menopause cause women to have a higher morbidity and mortality and a worse prognosis of CI than men of the same age. 8,9 This sets a warning that we need to pay extra attention to this condition, especially to prevent CI in older women.…”