Gender differences in plasma glial cell line-derived neurotrophic factor levels of patients with bipolar disorder

Ding, Lu-Yu; Wu, Yifan; Kong, Lingtao; Sun, Jiaze; Qu, Fangru; Xin, Kaiqi; Yang, Anqi; Yan, Xintong; Lu, Yihui; Jiang, Xiaowei; Tang, Yanqing; Wu, Fengpeng

doi:10.1016/j.jad.2022.09.123

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…Examples of strata-specific associations include elevated levels of 5 proteins associated with unfavorable outcome in women only. For GDNF [ 39 ], CCL3 [alias MIP-1α] [ 40 ], and CD40 [alias TNFSF5] [ 41 ] sex-differences have been observed in experimental or clinical studies. This was also reflected in the LASSO regressions, where GDNF, IL-10RB and SLAMF1 contributed to the separation of outcomes in women only.…”

Section: Discussionmentioning

confidence: 99%

Proteomic profiling identifies novel inflammation-related plasma proteins associated with ischemic stroke outcome

Angerfors,

Brännmark,

Lagging

et al. 2023

J Neuroinflammation

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Background The inflammatory response to cerebral ischemia is complex; however, most clinical studies of stroke outcome focus on a few selected proteins. We, therefore, aimed to profile a broad range of inflammation-related proteins to: identify proteins associated with ischemic stroke outcome that are independent of established clinical predictors; identify proteins subsets for outcome prediction; and perform sex and etiological subtype stratified analyses. Methods Acute-phase plasma levels of 65 inflammation-related proteins were measured in 534 ischemic stroke cases. Logistic regression was used to estimate associations to unfavorable 3-month functional outcome (modified Rankin Scale score > 2) and LASSO regressions to identify proteins with independent effects. Results Twenty proteins were associated with outcome in univariable models after correction for multiple testing (FDR < 0.05), and for 5 the association was independent of clinical variables, including stroke severity (TNFSF14 [LIGHT], OSM, SIRT2, STAMBP, and 4E-BP1). LASSO identified 9 proteins that could best separate favorable and unfavorable outcome with a predicted diagnostic accuracy (AUC) of 0.81; three associated with favorable (CCL25, TRAIL [TNFSF10], and Flt3L) and 6 with unfavorable outcome (CSF-1, EN-RAGE [S100A12], HGF, IL-6, OSM, and TNFSF14). Finally, we identified sex- and etiologic subtype-specific associations with the best discriminative ability achieved for cardioembolic, followed by cryptogenic stroke. Conclusions We identified candidate blood-based protein biomarkers for post-stroke functional outcome involved in, e.g., NLRP3 inflammasome regulation and signaling pathways, such as TNF, JAK/STAT, MAPK, and NF-κB. These proteins warrant further study for stroke outcome prediction as well as investigations into the putative causal role for stroke outcome.

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Section: Discussionmentioning

confidence: 99%

Proteomic profiling identifies novel inflammation-related plasma proteins associated with ischemic stroke outcome

Angerfors,

Brännmark,

Lagging

et al. 2023

J Neuroinflammation

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“…It has also been demonstrated that there are gender differences in serum neurotrophic factors in adolescents with depression and that they correlate with clinical severity [ 31 ]. Our recent study found that there was a gender difference in plasma glial cell line-derived neurotrophic factor levels of patients within bipolar disorder [ 32 ]. A fundamental finding arising from recent studies on the physiological role of microglia in neural development is their sexual dimorphism, suggesting that there is gender dimorphism in the underlying mechanisms of MDD [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Gender differences in plasma S100B levels of patients with major depressive disorder

Wu,

Lu,

Kong

et al. 2024

BMC Psychiatry

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Background Low concentrations of S100B have neurotrophic effects and can promote nerve growth and repair, which plays an essential role in the pathophysiological and histopathological alterations of major depressive disorder (MDD) during disease development. Studies have shown that plasma S100B levels are altered in patients with MDD. In this study, we investigated whether the plasma S100B levels in MDD differ between genders. Methods We studied 235 healthy controls (HCs) (90 males and 145 females) and 185 MDD patients (65 males and 120 females). Plasma S100B levels were detected via multifactor assay. The Mahalanobis distance method was used to detect the outliers of plasma S100B levels in the HC and MDD groups. The Kolmogorov–Smirnov test was used to test the normality of six groups of S100B samples. The Mann–Whitney test and Scheirer-Ray-Hare test were used for the comparison of S100B between diagnoses and genders, and the presence of a relationship between plasma S100B levels and demographic details or clinical traits was assessed using Spearman correlation analysis. Results All individuals in the HC group had plasma S100B levels that were significantly greater than those in the MDD group. In the MDD group, males presented significantly higher plasma S100B levels than females. In the male group, the plasma S100B levels in the HC group were significantly higher than those in the MDD group, while in the female group, no significant difference was found between the HC and MDD groups. In the male MDD subgroup, there was a positive correlation between plasma S100B levels and years of education. In the female MDD subgroup, there were negative correlations between plasma S100B levels and age and suicidal ideation. Conclusions In summary, plasma S100B levels vary with gender and are decreased in MDD patients, which may be related to pathological alterations in glial cells.

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A mediator between childhood trauma and clinical symptoms in females with bipolar disorder: social support

Yang,

Li,

et al. 2023

Preprint

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Background Bipolar disorder (BD) is a severer mental disorder with gender differences. Both childhood trauma and social support play important roles in the BD course, especially in female patients. In this study, the relationship between childhood trauma and clinical symptoms of BD was investigated in female patients and the mediation effect of social support on this relationship. Methods This study included 57 females with BD and 53 age-matched healthy controls. The measurement of childhood trauma, social support, and clinical symptoms were measured using self-report questionnaires and clinical scales. Results Compared with healthy controls, females with BD showed higher levels of childhood trauma and lower levels of social support. In the BD group, high levels of childhood trauma were positively correlated with clinical symptoms. In addition, social support mediated the relationship between childhood trauma and clinical symptoms of BD, except for manic symptoms. Conclusions Studies should focus on the role of childhood trauma and social support in females with bipolar disorder. This study provides initial evidence that social support partially explains the relationship between childhood trauma and clinical symptoms of BD. Interventions providing social support may be beneficial for females with BD exposed to childhood trauma.

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Gender differences in plasma glial cell line-derived neurotrophic factor levels of patients with bipolar disorder

Cited by 3 publications

References 38 publications

Proteomic profiling identifies novel inflammation-related plasma proteins associated with ischemic stroke outcome

Proteomic profiling identifies novel inflammation-related plasma proteins associated with ischemic stroke outcome

Gender differences in plasma S100B levels of patients with major depressive disorder

A mediator between childhood trauma and clinical symptoms in females with bipolar disorder: social support

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