Gender Differences in Psychological Symptoms and Quality of Life in Patients with Inflammatory Bowel Disease in China: A Multicenter Study

Liu, Chuan; Zhang, Jixiang; Chen, Min; An, Ping; Xiang, Jiankang; Yu, Rong; Zeng, Suqi; Wei, Shuchun; Deng, Beiying; Liu, Zhongchun; Jiang, Changqing; Shi, Jie; Wu, Kaichun; Dong, Weiguo

doi:10.3390/jcm12051791

Cited by 10 publications

(11 citation statements)

References 57 publications

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“…Compared to their male counterparts, female patients may have more emotional problems influenced by factors such as physical and psychological endurance 51 . Consequently, female patients should receive more psychological support 52 . Higher PSQI scores 48 were associated with female gender, implying that women have worse sleep quality.…”

Section: Discussionmentioning

confidence: 99%

Psychological symptoms and quality of life in patients with inflammatory bowel disease in China: A multicenter study

Zhang,

Liu,

et al. 2024

UEG Journal

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AimsTo investigate the current situation of mental psychology and quality of life (QoL) in patients with inflammatory bowel disease (IBD) in China, and analyze the influencing factors.MethodsA unified questionnaire was developed to collect clinical data on IBD patients from 42 hospitals in 22 provinces from September 2021 to May 2022. Multivariate Logistic regression analysis was conducted, and independent influencing factors were screened out to construct nomogram. The consistency index (C‐index), receiver operating characteristic (ROC) curve, area under the ROC curve (AUC), calibration curve, and decision curve analysis (DCA) were used to evaluate the discrimination, accuracy, and clinical utility of the nomogram model.ResultsA total of 2478 IBD patients were surveyed, including 1371 patients with ulcerative colitis (UC) and 1107 patients with Crohn's disease (CD). Among them, 25.5%, 29.7%, 60.2%, and 37.7% of IBD patients had anxiety, depression, sleep disturbance and poor QoL, respectively. The proportion of anxiety, depression, and poor QoL in UC patients was significantly higher than that in CD patients (all p < 0.05), but there was no difference in sleep disturbance between them (p = 0.737). Female, higher disease activity and the first visit were independent risk factors for anxiety, depression and sleep disturbance in IBD patients (all p < 0.05). The first visit, higher disease activity, abdominal pain and diarrhea symptoms, anxiety, depression and sleep disturbance were independent risk factors for the poor QoL of patients (all p < 0.05). The AUC value of the nomogram prediction model for predicting poor QoL was 0.773 (95% CI: 0.754–0.792). The calibration diagram of the model showed that the calibration curve fit well with the ideal curve, and DCA showed that the nomogram model could bring clinical benefits.ConclusionIBD patients have higher anxiety, depression, and sleep disturbance, which affect their QoL. The nomogram prediction model we constructed has high accuracy and performance when predicting QoL.

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Section: Discussionmentioning

confidence: 99%

Psychological symptoms and quality of life in patients with inflammatory bowel disease in China: A multicenter study

Zhang,

Liu,

et al. 2024

UEG Journal

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“…Scores exceeding 5 indicated sleep disturbance. 18 Based on the score range, sleep quality was classified as good (0-5), medium (6-10), poor (11)(12)(13)(14)(15), or very poor (16-21).…”

Section: Pittsburgh Sleep Quality Index (Psqi)mentioning

confidence: 99%

“…Higher scores indicated elevated levels of depression and anxiety. The severity of anxiety and depressive symptoms was categorized into minimal (0-4), mild (5-9), moderate (10)(11)(12)(13)(14)(15), and severe (>15) symptom levels. A cut-off score of 10 or higher was employed to signify probable diagnostic status on each measure.…”

Section: Introductionmentioning

confidence: 99%

“…Study design and patient populationThis study constituted a nationwide multicenter cross-sectional survey conducted in China between September 2021 and May 2022.The investigation, focusing on the mental state and QoL of patients with IBD, was carried out by the Psychology Club of the IBD Group of the Chinese Society of Gastroenterology, Chinese Medical Association and the Chinese Association for Mental Hygiene 13. The study comprised three distinct stages, ie, observation, training, and investigation.…”

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Geographic differences in psychological symptoms, sleep quality, and quality of life in patients with inflammatory bowel disease: A multicenter study in China

Liu,

Zhang,

et al. 2024

J of Digest Diseases

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ObjectiveWe aimed to explore the geographic differences in psychological symptoms, sleep quality, and quality of life (QoL) among adult patients with inflammatory bowel disease (IBD).MethodsA unified questionnaire was developed to collect data on psychological status and QoL of IBD patients from 42 hospitals across 22 provinces, municipalities, and autonomous regions in China's mainland from September 2021 to May 2022.ResultsA total of 2478 patients with IBD were surveyed. The proportions of patients with anxiety (28.5% vs 23.1%), depression (32.3% vs 27.8%), and poor QoL (44.8% vs 32.2%) were significantly higher in patients from the northern region compared to the southern region (all P < 0.05). In the western region, the proportions of patients with anxiety (31.9% vs 23.0%), depression (37.7% vs 26.7%), sleep disturbances (64.5% vs 58.5%), and poor QoL (44.9% vs 34.8%) were significantly higher than in the eastern and central regions (all P < 0.01). Patients from inland regions had significantly higher rates of anxiety (27.1% vs 23.3%), depression (32.5% vs 26.0%), sleep disturbance (62.0% vs 57.7%), and poor QoL (43.5% vs 29.9%) compared to those from coastal regions (all P < 0.05). In economically underdeveloped areas, the proportions of patients with depression (33.1% vs 28.5%) and poor QoL (52.0% vs 32.4%) were significantly higher than in economically (relatively) developed areas (both P < 0.05).ConclusionThere are significant geographic differences in psychological symptoms, sleep quality, and QoL among Chinese patients with IBD, which might provide valuable insights for global IBD research and clinical practice.

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“…Several differences in sex and clinical features of ulcerative colitis (UC) have been postulated. Among female patients with UC, proctitis is commonly observed [1][2][3], and another study indicates a higher percentage of severe cases in females compared to males [4].…”

Section: Introductionmentioning

confidence: 99%

Sex differences and fecal incontinence among Japanese patients with ulcerative colitis: A cross-sectional study

Hanayama,

Furukawa,

Miyake

et al. 2024

Preprint

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Background Several differences in sex and clinical features among patients with ulcerative colitis (UC) have been reported. Fecal incontinence (FI) is closely associated with quality of life; however, the evidence regarding sex differences and FI in patients with UC is limited and inconsistent. Aims This study aims to examine the relationship between sex, delivery history, and FI in Japanese patients with UC. Methods A total of 288 Japanese UC patients participated in this study. FI was defined based on self-reported incontinence frequency. Information on sex, delivery history, smoking status, and alcohol intake status was collected through a self-reported questionnaire. Medication, disease activity, and body mass index (BMI) information was collected from medical records. Results The female-to-male ratio and FI prevalence were 48.0% and 13.9%, respectively. FI was significantly more prevalent in female patients (21.5%) compared to male patients (8.4%). Female sex was significantly and positively associated with FI (adjusted odds ratio [OR], 2.99 [95% CI 1.51–6.16]). Drinking status, smoking status, and BMI were not associated with FI. In female UC patients, the percentages for no history of delivery, one delivery, and two or more deliveries were 33.1%, 13.2%, and 53.7%, respectively. However, history of delivery was not significantly associated with FI. Conclusions In Japanese patients with UC, female sex was independently and inversely associated with FI. Furthermore, in female patients, history of delivery was not significantly associated with FI.

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Gender Differences in Psychological Symptoms and Quality of Life in Patients with Inflammatory Bowel Disease in China: A Multicenter Study

Cited by 10 publications

References 57 publications

Psychological symptoms and quality of life in patients with inflammatory bowel disease in China: A multicenter study

Psychological symptoms and quality of life in patients with inflammatory bowel disease in China: A multicenter study

Geographic differences in psychological symptoms, sleep quality, and quality of life in patients with inflammatory bowel disease: A multicenter study in China

Sex differences and fecal incontinence among Japanese patients with ulcerative colitis: A cross-sectional study

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