Gender specific alterations in antioxidant status of aging Zaprionus paravittiger fed on propyl gallate

Bains, J. S.; Kakkar, Rakesh; Sharma, Suraj

doi:10.1080/15216549600201333

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…Propyl gallate is used extensively as an antioxidant in fats and oils to prevent rancidity and spoilage. Experimentally, propyl gallate has been shown to protect against free radical injury in-vitro in lung reperfusion models and when given as a dietary supplementation in in-vivo studies (Bhatnagar 1993;Bains et al 1996). Propyl gallate, a synthetic polyhydric phenol, is a member of the gallic acid ester family and has the capacity to act as a free radical scavenger in biological systems.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of propyl gallate against myocardial oxidative stress-induced injury in rat

Karthikeyan

Bai

Gauthaman

et al. 2005

Journal of Pharmacy and Pharmacology

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This study was designed to investigate the effect of chronic administration of propyl gallate on myocardial oxidative stress-induced injury. Propyl gallate was administered orally to Wistar albino rats (150-200 g) in three different doses, by gastric gavage (250 mg kg(-1) (P1), 500 mg kg(-1) (P2) and 750 mg kg(-1) (P3)), 6 days a week for 5 weeks. At the end of this period, all the rats, except the normal untreated rats that served as the control group, were administered isoproterenol (ISO), 85 mg kg(-1) subcutaneously, for 2 consecutive days to induce myocardial injury. After 48 h, rats (n = 6 per group) were anaesthetized with anaesthetic ether, sacrificed and the hearts were harvested for the estimation of thiobarbituric acid reactive substances (TBARS), endogenous antioxidants (reduced glutathione (GSH), superoxide dismutase (SOD) and catalase) and for the assessment of histological changes. In the P2 BL group (BL = baseline), there was a significant (P < 0.001) rise in baseline TBARS and SOD when compared with the saline-treated group, while no such changes were observed in the other baseline-treated groups. However, there was a significant (P < 0.001) increase in TBARS and endogenous anti-oxidants (GSH, SOD and catalase) in the P2 ISO and P3 ISO groups, when the hearts were subjected to in-vivo myocardial oxidative stress-induced injury. We observed no such changes in the P1 ISO group. This study showed that propyl gallate modulates the levels of endogenous antioxidants present at the myocardial site. Whether these modifications are a result of direct interference at this site or a remote effect is not immediately clear. In conclusion, from the results it could be stated that chronic administration of 500 mg kg(-1) of propyl gallate offers significant protection against myocardial oxidative stress-induced injury.

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Section: Discussionmentioning

confidence: 99%

Protective effect of propyl gallate against myocardial oxidative stress-induced injury in rat

Karthikeyan

Bai

Gauthaman

et al. 2005

Journal of Pharmacy and Pharmacology

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“…Stein et al (2003) and Setta and Carareto (2005) contributed significantly to our understanding of the life cycle of Z. indianus populations. These studies reported a greater longevity than in Z. indianus populations of Indian (Bains et al , 1995, 1996) and Saudi Arabian (Amoudi et al , 1991, 1993a) origin. The productivity of the species was similar to or greater than that of other drosophilids and the development time was very similar to that of D. sturtevanti.…”

Section: Introductionmentioning

confidence: 91%

Taxonomic and evolutionary analysis of Zaprionus indianus and its colonization of Palearctic and Neotropical regions

Commar¹,

Galego

Ceron

et al. 2012

Genet. Mol. Biol.

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Zaprionus indianus is a dipteran (Drosophilidae) with a wide distribution throughout the tropics and temperate Palearctic and Nearctic regions. There have been proposals to reclassify the genus Zaprionus as a subgenus or group of the genus Drosophila because various molecular markers have indicated a close relationship between Zaprionus species and the immigrans-Hirtodrosophila radiation within Drosophila. These markers, together with alloenzymes and quantitative traits, have been used to describe the probable scenario for the expansion of Zaprionus indianus from its center of dispersal (Africa) to regions of Asia (ancient dispersal) and the Americas (recent dispersal). The introduction of Z. indianus into Brazil was first reported in 1999 and the current consensus is that the introduced flies came from high-latitude African populations through the importation of fruit. Once in Brazil, Z. indianus spread rapidly throughout the Southeast and then to the rest of the country, in association with highway-based fruit commerce. These and other aspects of the evolutionary biology of Z. indianus are addressed in this review, including a description of a probable route for this species’ dispersal during its recent expansion.

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“…Propyl gallate increased catalase and glutathione reductase activities and enhanced life span of 2. paravittiger (28). One possible mechanism is that BHA induces or activates existing defense mechanisms that protect the organism from free radical damage.…”

Section: Discussionmentioning

confidence: 99%

Increased Longevity, Reduced Fecundity, and Delayed Development in Fruitfly (Zaprionus paravittiger) Fed on Butylated Hydroxy Anisole

Bains

Kakkar

Sharma

1997

Experimental Biology and Medicine

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Oxygen free radicals are generated as a by-product during normal metabolism, and they cause damage to proteins, lipids, and DNA in organisms. The defense system of the body counteracts these highly reactive chemical moieties and neutralizes them. However, a small fraction of free radicals escapes, which causes lipid peroxidation and hence aging of the organism. It has been hypothesized that, if the free radicals are arrested/reduced, then aging can be delayed or life span could be enhanced. To test the above hypothesis, we fed butylated hydroxy anisole (BHA) to a drosophilid insect, Zaprionus paravittiger, and observed its effect on life span, fecundity, and developmental period. The insects were reared and maintained on standard corn meal agar (CMA) medium at 26 degrees +/- 2 degrees C. Various concentrations (1, 5, 10, 25, 50, and 100 mM) of BHA were mixed with CMA medium, and the cultures were reared and maintained on these mixtures to study the life span of insects. Survivor curves showed that lower concentrations (5, 10, 25 mM) of BHA increased the life span, while higher concentrations (50, 100 mM), which were rather toxic, decreased life span. The most suitable concentration was 10 mM, which increased median (LT50) (27% and 15% in male and female) and maximum (LT100) (18% and 27% in male and female) life spans of insects maximally. Females exhibited longer life spans compared with males. The cultures were fed on the optimal concentration (10 mM) of BHA to study its effect on developmental period and egg-laying rate. The total developmental period was delayed by 7.2%, and egg-laying rate was reduced by 19.7% on BHA feeding. The extension in developmental period and reduction in egg-laying capacity could be the contributory factors to the favorable effect of BHA on life span.

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Gender specific alterations in antioxidant status of aging Zaprionus paravittiger fed on propyl gallate

Cited by 5 publications

References 17 publications

Protective effect of propyl gallate against myocardial oxidative stress-induced injury in rat

Protective effect of propyl gallate against myocardial oxidative stress-induced injury in rat

Taxonomic and evolutionary analysis of Zaprionus indianus and its colonization of Palearctic and Neotropical regions

Increased Longevity, Reduced Fecundity, and Delayed Development in Fruitfly (Zaprionus paravittiger) Fed on Butylated Hydroxy Anisole

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