Gender‐specific Links Between Hepatic 11β Reduction of Cortisone and Adipokines

Mattsson, Cecilia; Rask, Eva; Carlström, Kjell; Andersson, Jonas; Eliasson, Mats; Åhrén, Bo; Söderberg, Stefan; Olsson, Tommy

doi:10.1038/oby.2007.587

Cited by 6 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a recent study, hepatic 11 HSD1 activity was negatively associated with circulating levels of leptin and soluble TNF receptor 1 and 2 in males, even after adjusting for waist circumference, age, and insulin sensitivity. In contrast, hepatic 11 -reduction of cortisone was positively associated with leptin in females after adjustment for BMI and waist circumference [120]. In addition female, but not male, rat offspring fed a low-protein diet during preimplantation exhibited a 17% increase in hepatic 11 HSD1 mRNA expression; however, male, but not female offspring of dams fed a low-protein diet throughout gestation showed an increase of 27% in 11 HSD1 expression [121].…”

Section: Estrogen and Peripheral Cortisol Metabo-lismmentioning

confidence: 90%

Estrogens and Glucocorticoid Hormones in Adipose Tissue Metabolism

Mattsson¹,

Olsson

2007

CMC

Self Cite

119

View full text Add to dashboard Cite

Women have a higher percentage of body fat than men, and there is a gender-specific difference in fat distribution: Females tend to accumulate fat around the hips, buttocks, and thighs while men have a larger intra-abdominal (visceral) fat mass. After menopause, there is a redistribution of fat depots, and post-menopausal women develop increased amounts of visceral fat. The risk of developing obesity-related diseases is significantly lower in pre-menopausal women compared to men, a difference that is abolished after menopause, suggesting that the female sex steroid estrogen influences adipogenesis and adipose metabolism. Experimentally, estrogen increases the size and number of subcutaneous adipocytes and attenuates lipolysis. Post-menopausal women also develop a more atherogenic lipid pattern and decreased levels of the prothrombotic protein plasminogen activator inhibitor-1, which attenuates fibrinolysis. Pathologically increased circulating cortisol concentration is associated with dysmetabolic features e.g., central obesity, elevated blood pressure, insulin resistance, and dyslipidemia. In "simple obesity," glucocorticoid production is elevated. Peak levels of circulating cortisol are however low or normal, possibly because of increased clearance and/or tissue-specific changes in cortisol production. In addition to the adrenal production of cortisol, cortisol is also generated in adipose tissue by the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) which converts inactive cortisone to active cortisol. The enzyme activity in subcutaneous fat increases with increasing body weight. Estrogen seems to have a tissue-specific influence on 11betaHSD1 enzyme activity, attenuating it in liver, kidney, and testis but upregulating 11betaHSD1 mRNA expression in preadipocytes from women. In the present review, we summarize and discuss the interaction between glucocorticoids and sex steroids and their influence on adipocyte metabolism.

show abstract

Section: Estrogen and Peripheral Cortisol Metabo-lismmentioning

confidence: 90%

Estrogens and Glucocorticoid Hormones in Adipose Tissue Metabolism

Mattsson¹,

Olsson

2007

CMC

Self Cite

119

View full text Add to dashboard Cite

show abstract

“…Mattsson et al [ 31 ] found that 11β-HSD1 reduction activity was positively associated to leptin in females after adjustment for BMI and waist circumference. Li X et al [ 32 ] showed 11 β -HSD1 mRNA levels were positively associated with leptin in children .…”

mentioning

confidence: 99%

The Expression of 11β-HSDs, GR, and H6PDH in Subcutaneous Adipose Tissue from Polycystic Ovary Syndrome Subjects

Tao

Wang

et al. 2013

Horm Metab Res

View full text Add to dashboard Cite

The aim of the work was to investigate the expression of 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 and 2, hexose-6-phosphate dehydrogenase (H6PDH), and glucocorticoids receptor (GR) mRNA in subcutaneous adipose tissue (SAT) from obese women with or without polycystic ovary syndrome (PCOS), and the association between their expression and the adipocytokines' concentration. Sixteen women with PCOS (group P) and 18 age- and BMI-matched control women (group C) were enrolled for the study. Subcutaneous adipose tissue was collected from the abdomen. The genes' expression was detected by real-time PCR, and the adipocytokines' concentration was measured by ELISA. Peripheral insulin sensitivity was assessed by homeostatic assessment model of insulin resistance (HOMA-IR). β-cell function was assessed by homeostasis model assessment of β-cell function (HOMA-IS). The expression of 11β-HSD1 mRNA was significantly higher in PCOS subjects (p<0.05) than controls; there was no difference for the expression of 11β-HSD2, GR, and H6PDH mRNA between the 2 groups. The stepwise multiple linear regression analysis showed that the mRNA level of 11β-HSD1 was positively correlated to the concentration of the serum tumor necrosis factor-alpha (TNF-α). Expression of 11β-HSD1 mRNA was increased in the SAT from the women with PCOS, which may contribute to the increased local active glucocorticoids (cortisol), and subsequently affects the secretion of the local adipose tissue.

show abstract

Glucocorticoid mediates the transcription of OAT-PG, a kidney-specific prostaglandin transporter

Hatano

Mukouchi

Matsumoto

et al. 2013

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

OAT-PG is a kidney-specific prostaglandin transporter and exclusively expressed at the basolateral membrane of proximal tubules in rodent kidneys. We previously reported that OAT-PG was dominantly expressed in the male kidney similar to the other SLC22 family proteins as organic anion transporter (OAT) 1 and OAT3. Recently, Wegner et al. revealed that a transcription factor, B-cell CLL/lymphoma 6 (BCL6), is associated with the male-dominant expressions of OAT1 and OAT3 in the rat kidney. Here, we performed the luciferase assay to investigate whether OAT-PG is also transcriptionally regulated by BCL6. However, the promoter activity of OAT-PG was not directly affected by BCL6 overexpression nor the testosterone treatment, suggesting that different regulatory mechanisms underlie the male-dominant transcriptional regulation of OAT-PG compared to those of OAT1 and OAT3. We newly found that adrenalectomy (Adx) of male rat caused a significant reduction of OAT-PG expression without any significant changes in the OAT1 and OAT3 expressions, and it was recovered by the dexamethasone administration. Furthermore, the renocortical PGE2 concentration was markedly increased in Adx male rat, concomitant with the downregulation of OAT-PG, and it was reduced to the basal level by dexamethasone treatment. In the luciferase assay, dexamethasone stimulated OAT-PG promoter activity but not OAT1. The luciferase activity responsiveness to dexamethasone was significantly reduced by the deletion of glucocorticoid response elements in the OAT-PG promoter region. These results suggest that glucocorticoid plays an important role in the regulation of the renocortical PGE2 concentration by the transcriptional regulation of OAT-PG in the rat kidney.

show abstract

Gender‐specific Links Between Hepatic 11β Reduction of Cortisone and Adipokines

Cited by 6 publications

References 42 publications

Estrogens and Glucocorticoid Hormones in Adipose Tissue Metabolism

Estrogens and Glucocorticoid Hormones in Adipose Tissue Metabolism

The Expression of 11β-HSDs, GR, and H6PDH in Subcutaneous Adipose Tissue from Polycystic Ovary Syndrome Subjects

Glucocorticoid mediates the transcription of OAT-PG, a kidney-specific prostaglandin transporter

Contact Info

Product

Resources

About