Gene expression analysis suggests immunosuppressive roles of endolysosomes in glioblastoma
Michael A Sun,
Haipei Yao,
Qing Yang
et al.
Abstract:Targeting endolysosomes is a strategy extensively pursued for treating cancers, including glioblastomas (GBMs), mainly on the basis that the intact function of these subcellular organelles is key to tumor cell autophagy and survival. Here, by gene expression analyses and cell type abundance estimation in GBMs, we showed that genes associated with the endolysosomal machinery are more prominently featured in non-tumor cells in GBMs than in tumor cells, and that tumor-associated macrophages represent the primary … Show more
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