Gene expression biomarkers differentiate overall survival of colorectal cancer upon targeted therapies
Akram Yazdani,
Azam Yazdani,
Raul Mendez-Giraldez
et al.
Abstract:While monoclonal antibody-based targeted therapies have substantially improved progression-free survival in cancer patients, the variability in individual responses poses a significant challenge in patient care. Therefore, identifying cancer subtypes and their associated biomarkers is required for assigning effective treatment. In this study, we integrated genotype and pre-treatment tissue RNA-seq data and identified biomarkers causally associated with the overall survival (OS) of colorectal cancer (CRC) patie… Show more
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