Gene expression pattern of adiponectin and adiponectin receptors in dominant and atretic follicles and oocytes screened based on brilliant cresyl blue staining

Tabandeh, Mohammad Reza; Golestani, Navid; Kafi, M.; Hosseini, Ahmad; Saeb, M.; Sarkoohi, Parisa

doi:10.1016/j.anireprosci.2012.02.006

Cited by 25 publications

(15 citation statements)

References 52 publications

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“…A positive correlation is observed between the adiponectin transcript in the ovarian cells of the dominant follicle and follicular fluid E2 levels, indicating an association between adiponectin and follicular dominance and oocyte competence. 74 Adiponectin increases the production of progesterone in human ovaries, 62 though it does not alter estrogen production. 61,75 Treatment of human granulosa cells with adiponectin in vitro increases insulin-like growth factor I (IGF-1)-induced progesterone and E2 secretion but not IGF-1-induced proliferation.…”

Section: Direct Effects Of Adiponectin On the Female Gonadmentioning

confidence: 96%

The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis

et al. 2015

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Adipose tissue produces factors, including adipokines, cytokines and chemokines which, when released, systemically exert endocrine effects on multiple tissues thereby affecting their physiology. Adipokines also affect the hypothalamic-pituitary-gonadal (HPG) axis both centrally, at the hypothalamic-pituitary level, and peripherally acting on the gonads themselves. Among the adipokines, leptin, adiponectin, resistin, chemerin and the peptide kisspeptin have pleiotropic actions on the HPG axis affecting male and female fertility. Furthermore, adipokines and adipose tissue-produced factors readily affect the immune system resulting in inflammation, which in turn impact the HPG axis, thus evidencing a link between metabolic inflammation and fertility. In this review we provide an overview of the existing extensive bibliography on the crosstalk between adipose tissue-derived factors and the HPG axis, with particular focus on the impact of obesity and the metabolic syndrome on gonadal function and fertility.

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Section: Direct Effects Of Adiponectin On the Female Gonadmentioning

confidence: 96%

The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis

et al. 2015

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“…In bovine species, the physiological status of the ovary influences the expression pattern of adiponectin and its receptors in follicular and luteal cells (Tabandeh et al 2010). In these species, a positive correlation is also observed between the adiponectin transcript in the ovarian cells of the dominant follicle and follicular fluid oestradiol (E2) levels, indicating an association between adiponectin and follicular dominance and oocyte competence (Tabandeh et al 2012). In humans, ovarian adiponectin and AdipoRs expression are hormonally controlled in vivo, as suggested by an increase in adiponectin concentrations in the ovarian follicular fluid of women in response to LH treatment in the in vitro fertilisation procedure (Gutman et al 2009).…”

Section: Adiponectin Adipors and Resistin Expression In The Ovarymentioning

confidence: 99%

Adiponectin and resistin: potential metabolic signals affecting hypothalamo-pituitary gonadal axis in females and males of different species

Rak¹,

Mellouk²,

Froment³

et al. 2017

Reproduction

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Adipokines, including adiponectin and resistin, are cytokines produced mainly by the adipose tissue. They play a significant role in metabolic functions that regulate the insulin sensitivity and inflammation. Alterations in adiponectin and resistin plasma levels, or their expression in metabolic and gonadal tissues, are observed in some metabolic pathologies, such as obesity. Several studies have shown that these two hormones and the receptors for adiponectin, AdipoR1 and AdipoR2 are present in various reproductive tissues in both sexes of different species. Thus, these adipokines could be metabolic signals that partially explain infertility related to obesity, such as polycystic ovary syndrome (PCOS). Species and gender differences in plasma levels, tissue or cell distribution and hormonal regulation have been reported for resistin and adiponectin. Furthermore, until now, it has been unclear whether adiponectin and resistin act directly or indirectly on the hypothalamo-pituitary-gonadal axis. The objective of this review was to summarise the latest findings and particularly the species and gender differences of adiponectin and resistin on female and male reproduction known to date, based on the hypothalamo-pituitary-gonadal axis.Reproduction (2017) 153 R215-R226

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“…They showed that the expression levels of Adipor1 and Adipor2 were higher in bovine cumulus cells and oocyte derived from large growing follicle compared with that in cumulus cells and oocyte derived from small and medium follicles [6]. The association of adiponectin and its receptors genes with follicular dominance and oocyte competence was also confirmed [9]. However, changes in level of expression of adiponectin receptors during in vitro maturation and the effect of adiponectin on their expression have not been examined before.…”

Section: Discussionmentioning

confidence: 98%

“…However, adiponectin is expressed at undetectable or very low levels in mouse or human granulosa cells [7,8]. Tabandeh et al [9] showed that the theca/cumulus cells of high quality oocytes recovered from dominant follicles expressed higher amounts of adiponectin and its receptors compared to atretic follicles or lower quality oocytes during both the follicular and luteal phases in the bovine. However, results from studies in other species did not follow the same patterns.…”

Section: Introductionmentioning

confidence: 99%

The In Vitro Effect of Adiponectin on Early Bovine Embryonic Development and Transcriptomic Markers of Oocyte Competence

MR¹,

Kafi²

2016

JFIV Reprod Med Genet

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Objectives: The current study aimed to investigate the in vitro effects of physiologic concentration of adiponectin in follicular fluid of pre-ovulatory bovine ovarian follicles on: 1) the bovine oocyte maturation and the early developmental rates of bovine embryos in vitro; 2) the expression profiles of some developmentally important marker genes in the bovine cumulus cells and oocytes. Materials and Methods:The cumulus-oocyte complexes (COCs) were aspirated from abattoir ovaries and cultured in vitro in the presence/absence of the recombinant human (rh) adiponectin (5 µg/mL) and used for real time RT-QPCR and in vitro embryo production assays.Results: Adiponection had no significant effects on nuclear maturation and cumulus expansion rates (p > 0.05). The expression levels of hyaluronic synthase 2 gene (Has2) was significantly higher in the adiponection group compared to the control group (p = 0.014). However, the early embryonic development was not affected significantly in the presence of adiponectin. Adiponectin did not change the expression rates of adiponectin receptors or other markers of oocyte competence. Also, the expression rates of two important oocyte secreted factors (OSFs), bone morphogenetic protein 15 (Bmp15) and growth/differentiation factor 9 (Gdf9) were not affected (p > 0.05). Conclusions:Adiponection did not affect the bovine oocyte developmental competence and early embryo development in spite of a significant increase in the expression level of Has2 gene, a biomarker of the future oocyte developmental competence.

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Gene expression pattern of adiponectin and adiponectin receptors in dominant and atretic follicles and oocytes screened based on brilliant cresyl blue staining

Cited by 25 publications

References 52 publications

The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis

The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis

Adiponectin and resistin: potential metabolic signals affecting hypothalamo-pituitary gonadal axis in females and males of different species

The In Vitro Effect of Adiponectin on Early Bovine Embryonic Development and Transcriptomic Markers of Oocyte Competence

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