Gene polymorphism and circulating levels of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in coronary artery disease (CAD)

Braiek, A. Ben; Baudin, Bruno; Deloménie, Claudine; Gamra, Habib; Maatouk, Faouzi; Ali, Azaiez Med; Chahed, H.

doi:10.1016/j.atherosclerosis.2017.06.911

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“…TIMP is a type of MMP inhibitor, and MMP/TIMP imbalance can cause abnormal extracardiomyocyte collagen accumulation, which leads to ventricular stiffening and myocardial fibrosis and prevents myocardial relaxation and contraction. TIMPs can block MMPs from binding to their substrates and inhibit their activity, which subsequently delays the progression of ventricular remodeling (12,13). TIMP-3 is a member of the TIMP family and is a specific non-soluble protein that inhibits MMP activity.…”

Section: Discussionmentioning

confidence: 99%

Combination of serum TIMP-3, CA125, and NT-proBNP in predicting ventricular remodeling in patients with heart failure following acute myocardial infarction

Xie

Dang

Zhang

et al. 2020

Cardiovasc Diagn Ther

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Background: Left ventricular remodeling is the basic pathological mechanism of heart failure following acute myocardial infarction (AMI). Determining sensitive indexes for the early prediction of ventricular remodeling is important for the prevention of heart failure. This study aims to investigate the value of serum TIMP-3, CA125, and NT-proBNP in predicting ventricular remodeling in patients with heart failure following AMI.Methods: From May 2017 to May 2018, 93 patients with heart failure following AMI were enrolled in the study. The participants were divided into two groups: the ventricular remodeling group (n=51) and the nonventricular remodeling group (n=42). In addition, 47 healthy subjects who underwent physical examinations in the same period were enrolled as controls. Serum TIMP-3, CA125, and NT-proBNP were measured, in addition to the left ventricular wall thickness (LVWT) and left ventricular mass index (LVMI). The correlation of serum TIMP-3, CA125, and NT-proBNP with the LVWT and LVMI was analyzed, and its value in predicting ventricular remodeling was evaluated.Results: Serum TIMP-3 level was lower (P<0.05) and CA125 and NT-proBNP levels were higher (P<0.05) in both the ventricular remodeling and non-ventricular remodeling groups compared with the control group. Furthermore, the serum TIMP-3 level was lower in the ventricular remodeling group compared with the non-ventricular remodeling group (P<0.05), while the levels of CA125 and NT-proBNP were higher in the ventricular remodeling group compared with the non-ventricular remodeling group (P<0.05). The serum TIMP-3 level was negatively correlated with the LVWT and LVMI, while serum CA125 and NT-proBNP levels were positively correlated with the LVWT and LVMI, respectively. The area under the receiver operating characteristic curve of the combination of serum TIMP-3, CA125, and NT-proBNP levels in predicting ventricular remodeling was 0.850, and the prediction sensitivity and specificity were 74.51% and 87.71%, respectively. Conclusions:The combination of serum TIMP-3, CA125, and NT-proBNP can improve the sensitivity and specificity of predicting ventricular remodeling and can aid in the early prevention and treatment of heart failure.

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Section: Discussionmentioning

confidence: 99%