Gene polymorphism and the risk of coronary artery disease

Subbaraj, Gowtham Kumar; Varghese, Sindhu; Kulanthaivel, Langeswaran; Alagarsamy, Lakshmi; Rajaram, S.; Ramanathan, Sangeetha

doi:10.1016/b978-0-12-822706-0.00013-5

Cited by 5 publications

(4 citation statements)

References 65 publications

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“…It is well understood that oxidative stress is essential in the development of various conditions such as T2DM and CVD [11][12]. Because of the long-term presence of hyperglycemia and hyperinsulinemia, T2DM patients are prone to oxidative stress, which may contribute to the progression of atherosclerosis [13].…”

Section: Discussionmentioning

confidence: 99%

Progonostic effect of GSTM1/GSTT1 polymorphism in determining cardiovascular diseases risk among type 2 diabetes patients in South Indian population

Sobha

Ebenezar

2023

Mol Biol Rep

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BACKGROUNDCardiovascular disease (CVD) is a signi cant complication of type 2 diabetes mellitus (T2DM), with oxidative stress playing a signi cant role. Glutathione S-transferase (GST) polymorphisms -GSTM1, GSTT1 -have been linked to CVD and T2DM. The role of GSTM1 and GSTT1 in CVD development among T2DM patients in the South Indian population is investigated in this study. MATERIALS AND METHODSThe volunteers were grouped as Group 1: control, Group 2: T2DM, Group 3: CVD, and Group 4: T2DM with CVD (n = 100 each). Blood glucose, lipid pro le, plasma GST, MDA, and total antioxidants were measured. GSTM1 and GSTT1 were genotyped using PCR. RESULTSGSTT1 plays a signi cant role in the development of T2DM and CVD ), < 0.001 and 3.05(1.67-5.58), < 0.001] while GSTM1 null genotype was not associated with disease development.Individuals with dual null GSTM1/GSTT1 genotype had the highest risk of developing CVD [3.70(1.50-9.11), 0.004]. Group 2 and 3 individuals showed higher lipid peroxidation and lower total antioxidant levels. Pathway analysis further indicated that GSTT1 signi cantly affects GST plasma levels. CONCLUSIONGSTT1 null genotype may be considered as a factor for increasing the susceptibility and risk of CVD and T2DM in the South Indian population.

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Section: Discussionmentioning

confidence: 99%

Progonostic effect of GSTM1/GSTT1 polymorphism in determining cardiovascular diseases risk among type 2 diabetes patients in South Indian population

Sobha

Ebenezar

2023

Mol Biol Rep

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“…SNPs in miRNAs are powerful biomarkers having indicative or prognostic value and might be also a guide to identify the disease causative factors. [ 26 ] Recently, the association between miRNA polymorphisms and CHD risk is drawing more attention. In this study, we have validated the association between miRNA146a rs2910164 and miRNA5413 rs2168518 polymorphisms with the risk of the development of CHD by comparing CHD patients with controls groups from unrelated Egyptian populations, and further biochemical parameters were performed to identify the biological effects of those polymorphisms.…”

Section: Discussionmentioning

confidence: 99%

Study the association of microRNA polymorphisms (miR‐146a, miR‐4513) with the risk of coronary heart diseases in Egyptian population

Ali

Radwan

Elaraby

et al. 2022

J Biochem & Molecular Tox

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Coronary heart disease (CHD) is the most prevalent cause of cardiovascular mortality in the world. It is well established that microRNAs (miRNAs) and their variants have an essential role in regulating the development of cardiovascular physiology, thus impacting the pathophysiology of heart diseases. This study was designed to determine the possible association of miRNA polymorphisms (miRNA-146a rs2910164C/G and miR-4513 rs2168518G/A) with susceptibility to CHD in Egyptian patients and their correlation with different biochemical parameters. The study comprised 300 participants, including 200 unrelated patients with CHD and 100 healthy controls. Anthropometric and blood biochemical parameters were measured as well genetic analysis for rs2910164C/G and rs2168518G/A polymorphisms were performed for all subjects using TaqMan real-time PCR assay. Our results revealed that the biomedical parameters have a significant correlation between CHD patients and healthy controls with a p < 0.05. Analyses of genotype distribution for (rs2910164 and rs2168518) revealed a significant association with CHD [odd ratio = 4.54, confidence interval (CI 95%) = (2.41-8.53)] and [odd ratio = 0.88, (CI 95%) = (0.83-0.92)], respectively. Furthermore, a statistically significant difference was detected between lipid profile levels and both rs2910164 and rs2168518 polymorphisms. The present study's findings indicated that the selected polymorphisms, miR-146a rs2910164 and miR-4513 rs2168518 could represent a useful biomarker for susceptibility to CHD in the Egyptian population. These genetic characteristics and personal habits and environmental factors may contribute to the development of CHD.

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“…Atherosclerosis, along with diabetes mellitus, suggests having a connection through different pathophysiological pathways 18 . SNPs in miRNAs are powerful biomarkers having indicative or a prognostic value and also a guide to investigating the disease causative factors 19 . Microribonucleic acids (miRNAs) are of particular interest in this field, including miR-146a.…”

Section: Coronarymentioning

confidence: 99%

“…Furthermore, the rs2910164-G allele is associated with a reduction in expression levels of miR-146a 27 . MiR-146a is one of the most important miRNAs that shown to regulate inflammatory response and promote cell proliferation 19,30 . SNP rs2910164 includes alteration of C into G nucleotide substitution, leading to a mismatch in the stem or secondary structure of miRNA146a precursor; subsequently lowering the expression of pre-miR-146a 31 .…”

Section: G (Mutant)mentioning

confidence: 99%

Epigenetic Effect of MicroRNA in Coronary Heart Disease With and Without Diabetes

Ahmed

Amr

Zaher

et al. 2023

Azhar International Journal of Pharmaceutical and Medical Scien

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Coronary heart disease (CHD), as well as diabetes illness, remain the cause of mortality worldwide; hence, founding new biomarkers measurable in the initial stage of illness is necessary to accelerate treatment efficiency. Recently evidence has demonstrated alterations in miRNA levels associated with deregulated gene expression in diabetes and CHD. This case-control study investigates the probable effect of miR-146a rs2910164 C /G polymorphism in diabetes and atherosclerotic cardiovascular disease in Egyptian patients. The study comprised 210 individuals, including 70 CHD patients without diabetes, 70 CHD patients with diabetes, and 70 healthy controls, of Egyptian origin. Anthropometric and blood biochemical parameters were measured as well genetic analysis for rs2910164 C/G polymorphism was performed for all subjects using TaqMan realtime PCR assay. Our results revealed that; the biomedical parameters have a significant correlation between CHD with and without diabetes patients and healthy controls with a p-value <0.05. Analyses of genotype distribution for (rs2910164 C/G) revealed a significant association in both CHD with and without diabetes and control (odd ratio= 1.56, confidence interval (CI 95 %) = (0.06-0.63)) and (odd ratio= 0.88, (CI 95 %) = (0.83-0.92)) respectively. The current study's findings indicated that the selected polymorphism, miR-146a rs2910164 could represent a useful biomarker for susceptibility to CHD and diabetes in the Egyptian people.

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Gene polymorphism and the risk of coronary artery disease

Cited by 5 publications

References 65 publications

Progonostic effect of GSTM1/GSTT1 polymorphism in determining cardiovascular diseases risk among type 2 diabetes patients in South Indian population

Progonostic effect of GSTM1/GSTT1 polymorphism in determining cardiovascular diseases risk among type 2 diabetes patients in South Indian population

Study the association of microRNA polymorphisms (miR‐146a, miR‐4513) with the risk of coronary heart diseases in Egyptian population

Epigenetic Effect of MicroRNA in Coronary Heart Disease With and Without Diabetes

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