Gene Polymorphisms and Serum Levels of Pro- and Anti-Inflammatory Markers in Dengue Viral Infections

Feitosa, Rosimar Neris Martins; Vallinoto, Antônio Carlos Rosário; Vasconcelos, Pedro Fernando da Costa; Azevedo, Raimunda do Socorro da Silva; Azevedo, Vânia Nakauth; Machado, Luiz Fernando Almeida; Lima, Sandra Souza; Ishak, Marluísa de Oliveira Guimarães; Ishak, Ricardo

doi:10.1089/vim.2016.0026

Cited by 25 publications

(11 citation statements)

References 77 publications

(102 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For type II IFNs, the serum level of IFN- γ was higher in dengue patients than in healthy individuals [ 22 ]. The same finding was also reported by Feitosa et al [ 23 ]. The serum level of IFN- γ was gradually decreased in 3–5 days, 6-7 days, 8–10 days, and 14–17 days since illness onset in both mild and severe dengue patients [ 24 ], and it was higher in severe dengue patients in 8–10 days after illness onset compared with the mild dengue patients, but no difference was found in the other times between these two groups [ 24 ].…”

Section: Initial Immune Response To Dengue In Pregnant Womensupporting

confidence: 91%

Roles of Interferons in Pregnant Women with Dengue Infection: Protective or Dangerous Factors

Zhang

Zeng

et al. 2017

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

Dengue infection is a serious public health problem in tropical and subtropical areas. With the recent outbreaks of Zika disease and its reported correlation with microcephaly, the large number of pregnancies with dengue infection has become a serious concern. This review describes the epidemiological characteristics of pregnancy with dengue and the initial immune response to dengue infection, especially in IFNs production in this group of patients. Dengue is much more prevalent in pregnant women compared with other populations. The severity of dengue is correlated with the level of IFNs, while the serum IFN level must be sufficiently high to maintain the pregnancy and to inhibit virus replication.

show abstract

Section: Initial Immune Response To Dengue In Pregnant Womensupporting

confidence: 91%

Roles of Interferons in Pregnant Women with Dengue Infection: Protective or Dangerous Factors

Zhang

Zeng

et al. 2017

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

show abstract

“…Only 3 studies assessed both TNF-α -308 G>A and TNF-α 238 G>A [ 26 , 30 , 32 ] in the risk of severe dengue. Summary of the 11 excluded studies [ 33 – 43 ] were provided in S3 Table .…”

Section: Resultsmentioning

confidence: 99%

Association of tumour necrosis factor-α (TNF-α) gene polymorphisms (-308 G>A and -238 G>A) and the risk of severe dengue: A meta-analysis and trial sequential analysis

et al. 2018

View full text Add to dashboard Cite

Individual studies have assessed the association between TNF-α-308G>A and TNF-α-238 G>A polymorphisms and severity of dengue infection. However, the results are inconclusive and most studies had small sample sizes. The objective of this study was to summarize the evidence of association between TNF-α-308 G>A and TNF-α-238 G>A and severity of dengue infection.This study follows the preferred reporting items for systematic reviews and meta- analyses of genetic association studies, recommended by PLOS One. We calculated pooled odds ratio and its 95% confidence interval (CI) to estimate the association between TNF-α-308 G>A or TNF-α-238 G>A and the risk of severe dengue infections. To determine the information size required for this meta-analysis study, a trial sequential analysis (TSA) was done. Eight studies (640 cases and 1275 controls), which assessed the association of TNF-α-308 G>A or TNF-α-238 G>A and the risk of DHF were included. Overall, we found no significant association between TNF-α-308 G>A and the DHF risk in the allelic model (OR, 0.91; 95% CI, 0.51–1.63), the recessive model (OR,1.32;95%CI,0.73–2.37), the dominant model (OR,0.93;95%CI:0.59–1.47) or the additive model (OR,1.43,95;95%CI:0.79–2.59). There was also no significant association between TNF-α-238 G>A and DHF risk under the allele contrast model (OR:1.51;95%CI:0.88–2.58), the recessive model (OR,1.48,95% CI:0.33–6.58), the dominant model (OR,1.48;95%CI:0.56–3.92), or the additive model (OR:1.5;95%CI:0.34–6.69). On subgroup analysis, neither the Asian population nor the non-Asian population showed significant association between TNF-α-308 G>A/TNF-α-238 G>A and the DHF risk under any genetic models. Leave-one-out meta-analysis showed stability of the results. TSA plots suggested that the sample size in this meta-analysis study was below the required information size.The findings suggest an inclusive evidence of the association between TNF-α-308/ TNF-α-238 G>A and the risk of developing severe dengue infection. Large studies with evidence of Hardy-Weinberg equilibrium, assessing gene-gene interactions are recommended.

show abstract

“…The maximum total score is 20. Studies could be divided into three grades: grade A (high quality, scored [15][16][17][18][19][20], grade B (medium quality, scored [8][9][10][11][12][13][14], and grade C (low quality, scored 0-7).…”

Section: Methodological Qualitymentioning

confidence: 99%

“…In addition, polymorphisms (rs13306435 and rs2069849) in the IL-6 gene exon have been reported to be associated with different profiles of plasma IL-6 response to immunization [18]. As polymorphisms of IL-6 and IL-10 gene may alter IL-6 and IL-10 expressions [19], we used immunohistochemistry (IHC) and RT-PCR to evaluate IL-6 and IL-10 expression levels in intervertebral disc between the LDD patients and the control subjects.…”

Section: Introductionmentioning

confidence: 99%

Gene polymorphisms and expression levels of interleukin-6 and interleukin-10 in lumbar disc disease: a meta-analysis and immunohistochemical study

Guan

Wang

et al. 2020

J Orthop Surg Res

View full text Add to dashboard Cite

Background: To investigate the association between interleukin-6 (IL-6) (rs1800795, rs1800796, rs1800797, rs13306435, rs2069849) and interleukin-10 (IL-10) (rs1800871, rs1800896) gene polymorphisms, expression levels, and lumbar disc disease (LDD). Methods: We conducted a literature research on PubMed, Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure (CNKI) until February 28, 2019. We included all case-control studies about the association between IL-6 and IL-10 gene polymorphisms and LDD. The odds ratio (OR) and 95% confidence interval (CI) were calculated to estimate the strength of association. Statistical analysis was conducted by Review Manager (RevMan) 5.3 software. Furthermore, immunohistochemistry (IHC) and RT-PCR were performed to evaluate IL-6 and IL-10 expressions in the normal and degenerated disc. Results: A total of 6 studies, involving 1456 cases and 1611 controls, were included in this meta-analysis. G alleles of rs1800795 and rs1800797 in the IL-6 gene were significantly associated with LDD (rs1800795: G vs. C, OR = 1.38, 95% CI = 1.16-1.64, P = 0.0002; rs1800797: G vs. A, OR = 1.35, 95% CI = 1.14-1.61, P = 0.0006). Begg's funnel plot and Egger's tests did not show any evidence of publication bias. IL-6 expression and IL-6 mRNA levels were significantly increased in the degenerated disc compared with those in the normal disc (IL-6 immunopositive cells, 73.68 ± 10.99% vs. 37.23 ± 6.42%, P < 0.001). Conclusions: IL-6 gene polymorphisms (rs1800795 and rs1800797) were significantly associated with susceptibility to LDD. A high expression level of IL-6 may be an important risk factor for LDD.

show abstract

Gene Polymorphisms and Serum Levels of Pro- and Anti-Inflammatory Markers in Dengue Viral Infections

Cited by 25 publications

References 77 publications

Roles of Interferons in Pregnant Women with Dengue Infection: Protective or Dangerous Factors

Roles of Interferons in Pregnant Women with Dengue Infection: Protective or Dangerous Factors

Association of tumour necrosis factor-α (TNF-α) gene polymorphisms (-308 G>A and -238 G>A) and the risk of severe dengue: A meta-analysis and trial sequential analysis

Gene polymorphisms and expression levels of interleukin-6 and interleukin-10 in lumbar disc disease: a meta-analysis and immunohistochemical study

Contact Info

Product

Resources

About