Gene polymorphisms as predictors of response to biological therapies in psoriasis patients

Linares-Pineda, Teresa María; Cañadas-Garre, Marisa; Sánchez–Pozo, Antonio; Calleja‐Hernández, Miguel Ángel

doi:10.1016/j.phrs.2016.07.020

Cited by 22 publications

(27 citation statements)

References 51 publications

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“…The work of Leite Dantas et al further explored the interactions between macrophages and Tregs in TNF‐inflamed skin. Furthermore, under predominance of IL‐17, conversion of Foxp3 + cells to IL‐17‐producing cells may occur . Regarding translation to the clinic, consideration of a patient's individual genetic susceptibility profile and cytokine and immune cell composition at inflammatory sites may be key to long‐term successful therapy decisions in the treatment of inflammatory conditions .…”

Section: Cytokine‐dependent Immune Cell Plasticity In Skin Inflammationmentioning

confidence: 99%

Skin under Tnf influence: how regulatory T cells work against macrophages in psoriasis

Gatzka

2016

The Journal of Pathology

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Section: Cytokine‐dependent Immune Cell Plasticity In Skin Inflammationmentioning

confidence: 99%

Skin under Tnf influence: how regulatory T cells work against macrophages in psoriasis

Gatzka

2016

The Journal of Pathology

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“…Although the precise mechanism of human psoriasis remains somewhat enigmatic. It is increasingly recognized that strong genetic predisposition act as an intrinsic factor for psoriasis pathogenesis, and SNPs in the human genome may be one of the keys to unlock insights into the genetic basis for the occurrence, development and relapse of psoriasis [32,33]. As intrinsic factors, polymorphisms in TNFAIP3 and TNIP1 gene has garnered considerable attention over the past decade years by different research teams all over the world.…”

Section: Discussionmentioning

confidence: 99%

Association of rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms with psoriasis susceptibility: a meta-analysis of case-control studies

Gong

Gao

et al. 2020

BMC Med Genet

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Background: To date, the fundamental pathophysiology underlying the occurrence and progression of psoriasis are still unanswered questions. Genome-wide association surveys have revealed that TNFAIP3 and TNIP1 were key biomarkers for psoriasis. Here, we intended to conduct a survey on the association between TNFAIP3 and TNIP1 gene polymorphisms and psoriasis risk. Methods: A comprehensive search of four online databases-China National Knowledge Infrastructure (CNKI), PubMed, Embase, and Cochrane Library was undertaken up to August 25, 2019. We chose allele genetic model to deal with the original data. Newcastle-Ottawa scale (NOS) was used to evaluate the risk bias of each study. The RevMan 5.3 software was used to calculate the combined odds ratio and 95% confidence interval. Results: In total, we included 13 case-control studies consist of 13,908 psoriasis patients and 20,051 controls in this work. Our results demonstrated that rs610604 in TNFAIP3 polymorphism was significantly associated with psoriasis risk using random-effect model (G vs. T, OR = 1.19, 95% CI: 1.09-1.31, P = 0.0002), and a significant association between rs17728338 in TNIP1 polymorphism and psoriasis vulnerability using fixed-effect model (A vs. G, OR = 1.69, 95% CI:1.58-1.80, P < 0.00001). Conclusions: Our findings indicated that rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms were associated with psoriasis susceptibility.

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“…Although the precise mechanism of human psoriasis remains somewhat enigmatic. It is increasingly recognized that strong genetic predisposition act as intrinsic factor for psoriasis pathogenesis, and SNPs in human genome may be one of the keys to unlock insights into genetic basis for the occurrence, development and relapse of psoriasis 32,33 . As intrinsic factors, polymorphisms in TNFAIP3 and TNIP1 gene has garnered considerable attention over the past decade years by different research teams all over the world.…”

Section: Discussionmentioning

confidence: 99%

Association of rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms with psoriasis susceptibility: A meta-analysis of case-control studies

Gong

Gao

et al. 2020

Preprint

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Background: To date, The pathological mechanisms underlying the occurrence and development of psoriasis are still unanswered questions. Genome-wide association surveys have revealed that TNFAIP3 and TNIP1 were key biomarkers for psoriasis. This study aimed to investigate the association between TNFAIP3 and TNIP1 gene polymorphisms with psoriasis susceptibility. Methods: Comprehensive literature search was undertook across four online databases-PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure (CNKI) up to August 25, 2019. Allele model of inheritance was used to analyze the original data. Newcastle-Ottawa scale (NOS) was used to evaluate the risk bias of each study. Pooled odds ratios and 95% confidence intervals were calculated using the RevMan 5.3 software.Results: In all, 13 case-control studies comprising 13,908 psoriasis patients and 20,051 controls were identified and included in this meta-analysis. The results demonstrated that rs610604 in TNFAIP3 polymorphism was significantly associated with psoriasis risk using random effect model (G vs. T, OR = 1.19, 95 % CI: 1.09-1.31, P = 0.0002), and a significant association between rs17728338 in TNIP1 polymorphism and psoriasis vulnerability using fixed effect model (A vs. G, OR = 1.69, 95% CI:1.58-1.80, P < 0.00001).Conclusions: This meta-analysis indicated that rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms were associated with psoriasis susceptibility.

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Gene polymorphisms as predictors of response to biological therapies in psoriasis patients

Cited by 22 publications

References 51 publications

Skin under Tnf influence: how regulatory T cells work against macrophages in psoriasis

Skin under Tnf influence: how regulatory T cells work against macrophages in psoriasis

Association of rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms with psoriasis susceptibility: a meta-analysis of case-control studies

Association of rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms with psoriasis susceptibility: A meta-analysis of case-control studies

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