Gene polymorphisms in the interleukins gene and the risk of acute pancreatitis: A meta-analysis

Zhu, Xiaoyan; Hou, Chunmei; Tu, Min; Chen, Shi; Yin, Lingdi; Peng, Yunpeng; Li, Qiang

doi:10.1016/j.cyto.2018.12.003

Cited by 8 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Odds ratio (OR) and 95% confidence interval (CI) were counted to make an assessment of the association power in four different models, which comprised of allele comparison model, homozygote comparison model, recessive model and dominant model [7]. The χ 2 test which is based on Q -statistic was used and I 2 statistics was also put into use.…”

Section: Methodsmentioning

confidence: 99%

Association between the IL-10-1082G/A, IL-10-819T/C and IL-10-592A/C polymorphisms and Brucellosis susceptibility: a meta-analysis

2019

View full text Add to dashboard Cite

Brucellosis is a widespread zoonosis caused by small bacteria of the genus Brucella. The promoter polymorphisms of IL-10 (-1082 loci, -819 loci and -590 loci) are closely related to the production of IL-10, leading to the alteration of development and pathogenesis of Brucellosis. However, the previous results were controversial. In the present study, we conduct the meta-analysis to get a more precise result of IL-10 polymorphisms with Brucellosis risk. The quality of the studies was assessed according to a predefined scale. The odds ratio (OR) and 95% confidence interval (CI) were counted to evaluate the association strength. No significant association was found between position -1082 loci or -590 loci polymorphism and Brucellosis risk. The significant association was found in Asian population of position -819 (T vs. C: OR 0.60, 95% CI 0.44–0.82, P = 0.001), homozygote comparison (TT vs. CC: OR 0.24, 95% CI 0.09–0.62, P = 0.003) and recessive genetic model (TT vs. TC/CC: OR 0.22, 95% CI 0.05–0.91, P = 0.036). The present meta-analysis demonstrates that IL-10-819 loci polymorphism is not associated with Brucellosis risk of Caucasian population but may contribute a decreased risk to Asian population. And neither IL-10-1082 loci nor -592 loci polymorphism is associated with Brucellosis risk.

show abstract

Section: Methodsmentioning

confidence: 99%

Association between the IL-10-1082G/A, IL-10-819T/C and IL-10-592A/C polymorphisms and Brucellosis susceptibility: a meta-analysis

2019

View full text Add to dashboard Cite

show abstract

“…По результатам метаанализа, проведенного Zhu, Xiaole и др. (2019), выявлена корреляция между носительством ОНП rs1143634 (+3954 C/T) и rs16944 (-511C/T), и повышенным риском возникновения и тяжелого течения ОП [14]. Напротив, исследование, проведенное в 2015 году Bao X.B и Ma Z., а также метаанализ, проведенный в 2015 году Li D., Li J., не выявили существенной связи между носительством вышеуказанных полиморфизмов и риском развития и тяжелого течения ОП [15,16], что согласуется с исследованием, проведённым в 2007 Chen et al в китайской популяции, которое показало отсутствие существенной связи между носительством ОНП rs16944 (-511C/T) и риском ОП [17].…”

Section: результаты и обсуждениеunclassified

Role of polymorphisms rs16944 (-511C/T) of IL1B gene and rs1143634 (+ 3954 C/T) of IL1B gene as genetic predictors of acute pancreatitis

Дунаевская

Sergeeva

Deulina

et al. 2023

jour

View full text Add to dashboard Cite

Purpose. Identify the role of ONP rs16944 (-511C/T) of the IL1B gene and rs1143634 (+ 3954 C/T) of the IL1B gene in the development of acute pancreatitis. Material and methods. The study involved 296 people diagnosed with acute pancreatitis. There were 124 (41.89%) males and 172 (58.11%) females. By age, patients ranged from 24 to 83 years old, the average age was 44,3±12,6 years. Patients with mild severity OP - 103 (34.79%) people, moderate severity OP - 110 (37.16%) people, severe severity OP - 83 (28.05%) people. The control group amounted to 78 people. Genomic DNA was isolated by sorption method, the carrier of rs16944 (-511C/T) and rs1143634 (+ 3954C/T) of the IL1B gene was determined by real-time polymerase chain reaction using TaqMan allele discrimination technology and commercially available fluorescence probes. Results. Our study revealed a statistically significant increase in the frequency of carriage of the rs16944 (-511C/T) IL1B gene located in the promoter region of the functional polymorphism, which correlates with the severity of acute pancreatitis. It is known that this polymorphism enhances gene expression and leads to an increase in the level of proinflammatory cytokine. On the other hand, there is no correlation between the presence of the structural polymorphism rs1143634 (+ 3954 C/T), localized in exon 5 of the gene IL1B and the development of the disease, as well as the severity. Conclusions. Thus, it can be assumed that in residents of Krasnoyarsk, the carriage of the rs16944 (-511C/T) ONP gene IL1B is a predictor of the development of acute pancreatitis and severe disease, which coincides with the data obtained when compared with the European population of the NCBI base.

show abstract

“…For example, SNPs rs1800871 (-819C/T) and rs1800872 (-592C/A) were associated with increased susceptibility to inflammatory bowel disease (IBD) in overall populations (117), but the same polymorphisms have decreased susceptibility to systemic lupus erythematosus (SLE) in Asian populations and hospital-based subgroups, respectively (118). However, it is to be noted that disease associations with SNPs in the IL-10 gene do not necessarily prove their causative role, and better interpretations can be made in studies involving large sample sizes, and ethnically diverse populations (116). Likewise, it is unknown whether the SNPs alter the production of IL-10 in different cell types.…”

Section: Responses To Il-10mentioning

confidence: 99%

IL-10 as a Th2 Cytokine: Differences Between Mice and Humans

Rasquinha

Sur

Lasrado

et al. 2021

The Journal of Immunology

View full text Add to dashboard Cite

The discovery of IL-10 more than 30 years ago marked the beginning of our understanding of how cytokines regulate immune responses, based on cross-regulation between Th1 and Th2 cytokines. Although multiple cell types were shown to produce IL-10, its identity as a Th2 cytokine remained strong because it was rigidly associated with Th2 clones in mice, whereas both Th1 and Th2 clones could secrete IL-10 in humans. However, as new Th1/Th2 cell functionalities emerged, anti-inflammatory action of IL-10 gained more attention than its inhibitory effect on Th1 cells, which may occur as an indirect consequence of suppression of APCs. This notion is also supported by the discovery of regulatory T cells, whose suppressor functions involve the mediation of IL-10, among other molecules. From this perspective, we discuss the functionalities of IL-10 by highlighting important differences between mice and humans with an emphasis on the Th1 and Th2 paradigm.

show abstract

Gene polymorphisms in the interleukins gene and the risk of acute pancreatitis: A meta-analysis

Cited by 8 publications

References 28 publications

Association between the IL-10-1082G/A, IL-10-819T/C and IL-10-592A/C polymorphisms and Brucellosis susceptibility: a meta-analysis

Association between the IL-10-1082G/A, IL-10-819T/C and IL-10-592A/C polymorphisms and Brucellosis susceptibility: a meta-analysis

Role of polymorphisms rs16944 (-511C/T) of IL1B gene and rs1143634 (+ 3954 C/T) of IL1B gene as genetic predictors of acute pancreatitis

IL-10 as a Th2 Cytokine: Differences Between Mice and Humans

Contact Info

Product

Resources

About