Gene signature based on B cell predicts clinical outcome of radiotherapy and immunotherapy for patients with lung adenocarcinoma

Shi, Hongjie; Luo, Yuan; Sun, Wenjie; Li, Shuying; Zhang, Nannan; Jiang, Xueping; Gong, Yan; Xie, Conghua

doi:10.1002/cam4.3561

Cited by 20 publications

(16 citation statements)

References 66 publications

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“…As a kind of immune cells, B cells can fight against tumors through the production of antibodies, antigen royalty or the secretion of immune regulatory factors (Stoycheva et al, 2021). Han et al (2020) found that B cells can be used as an independent indicator of OS prediction in LUAD. It is well known that methylation plays an important role in the development of cancer.…”

Section: Discussionmentioning

confidence: 99%

ALKBH1-8 and FTO: Potential Therapeutic Targets and Prognostic Biomarkers in Lung Adenocarcinoma Pathogenesis

Yan

Cai

et al. 2021

Front. Cell Dev. Biol.

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The AlkB family consists of Fe(II)- and α-ketoglutarate-dependent dioxygenases that can catalyze demethylation on a variety of substrates, such as RNA and DNA, subsequently affecting tumor progression and prognosis. However, their detailed functional roles in lung adenocarcinoma (LUAD) have not been clarified in a comprehensive manner. In this study, several bioinformatics databases, such as ONCOMINE, TIMER, and DiseaseMeth, were used to evaluate the expression profiles and prognostic significance of the AlkB family (ALKBH1-8 and FTO) in LUAD. The expression levels of ALKBH1/2/4/5/7/8 were significantly increased in LUAD tissues, while the expression levels of ALKBH3/6 and FTO were decreased. The main functions of differentially expressed AlkB homologs are related to the hematopoietic system and cell adhesion molecules. We also found that the expression profiles of the AlkB family are highly correlated with infiltrating immune cells (i.e., B cells, CD8 + T cells, CD4 + T cells, macrophages, neutrophils and dendritic cells). In addition, DNA methylation analysis indicated that the global methylation levels of ALKBH1/2/4/5/6/8 and FTO were decreased, while the global methylation levels of ALKBH3/7 were increased. In addition, the patients with upregulated ALKBH2 have significantly poor overall survival (OS) and post-progressive survival (PPS). Taken together, our work could provide insightful information about aberrant AlkB family members as potential biomarkers for the diagnostic and prognostic evaluation of LUAD. Especially, ALKBH2 could be served as a therapeutic candidate for treating LUAD.

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Section: Discussionmentioning

confidence: 99%

ALKBH1-8 and FTO: Potential Therapeutic Targets and Prognostic Biomarkers in Lung Adenocarcinoma Pathogenesis

Yan

Cai

et al. 2021

Front. Cell Dev. Biol.

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“…Additionally, PARP15 is a tumor-infiltrating B lymphocyte-specific gene (TILBSig) that is highly associated with OS ( Table 4 ). TILBSigs serve as excellent predictors of the response to immunotherapy and radiotherapy in lung adenocarcinoma patients ( 107 ). PARP7 MARylates TANK binding kinase 1, a major kinase related to the activation of the type I IFN response and antiviral immunity, thereby repressing the type I IFN response.…”

Section: Role Of the Parp Family In Other Cancersmentioning

confidence: 99%

Research Advances in the Role of the Poly ADP Ribose Polymerase Family in Cancer

et al. 2021

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Poly ADP ribose polymerases (PARPs) catalyze the modification of acceptor proteins, DNA, or RNA with ADP-ribose, which plays an important role in maintaining genomic stability and regulating signaling pathways. The rapid development of PARP1/2 inhibitors for the treatment of ovarian and breast cancers has advanced research on other PARP family members for the treatment of cancer. This paper reviews the role of PARP family members (except PARP1/2 and tankyrases) in cancer and the underlying regulatory mechanisms, which will establish a molecular basis for the clinical application of PARPs in the future.

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“…The 13‐gene signature constructed by He et al 13 with metabolism‐related genes was helpful to predict the prognoses of patients with LUAD. Han et al 14 constructed a multi‐gene signature based on tumour‐infiltrating B lymphocyte–specific genes to predict the clinical outcome of radiotherapy and immunotherapy in patients with LUAD. Li et al 15 used a 6‐gene signature to predict the prognoses of patients with LUAD.…”

Section: Introductionmentioning

confidence: 99%

Systematic profiling of invasion‐related gene signature predicts prognostic features of lung adenocarcinoma

Tong

Song

et al. 2021

J Cellular Molecular Medi

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Due to the high heterogeneity of lung adenocarcinoma (LUAD), molecular subtype based on gene expression profiles is of great significance for diagnosis and prognosis prediction in patients with LUAD. Invasion‐related genes were obtained from the CancerSEA database, and LUAD expression profiles were downloaded from The Cancer Genome Atlas. The ConsensusClusterPlus was used to obtain molecular subtypes based on invasion‐related genes. The limma software package was used to identify differentially expressed genes (DEGs). A multi‐gene risk model was constructed by Lasso‐Cox analysis. A nomogram was also constructed based on risk scores and meaningful clinical features. 3 subtypes (C1, C2 and C3) based on the expression of 97 invasion‐related genes were obtained. C3 had the worst prognosis. A total of 669 DEGs were identified among the subtypes. Pathway enrichment analysis results showed that the DEGs were mainly enriched in the cell cycle, DNA replication, the p53 signalling pathway and other tumour‐related pathways. A 5‐gene signature (KRT6A, MELTF, IRX5, MS4A1 and CRTAC1) was identified by using Lasso‐Cox analysis. The training, validation and external independent cohorts proved that the model was robust and had better prediction ability than other lung cancer models. The gene expression results showed that the expression levels of MS4A1 and KRT6A in tumour tissues were higher than in normal tissues, while CRTAC1 expression in tumour tissues was lower than in normal tissues. The 5‐gene signature prognostic stratification system based on invasion‐related genes could be used to assess prognostic risk in patients with LUAD.

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Gene signature based on B cell predicts clinical outcome of radiotherapy and immunotherapy for patients with lung adenocarcinoma

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 20 publications

References 66 publications

ALKBH1-8 and FTO: Potential Therapeutic Targets and Prognostic Biomarkers in Lung Adenocarcinoma Pathogenesis

ALKBH1-8 and FTO: Potential Therapeutic Targets and Prognostic Biomarkers in Lung Adenocarcinoma Pathogenesis

Research Advances in the Role of the Poly ADP Ribose Polymerase Family in Cancer

Systematic profiling of invasion‐related gene signature predicts prognostic features of lung adenocarcinoma

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