2009
DOI: 10.1177/172460080902400109
|View full text |Cite
|
Sign up to set email alerts
|

Gene-Specific Methylation: Potential Markers for Colorectal Cancer

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2012
2012
2022
2022

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 6 publications
(2 citation statements)
references
References 16 publications
0
2
0
Order By: Relevance
“…However, LYN overexpression has been reported in several cancers [ 26 32 ]. In addition, the regulation of LYN by DNA methylation was demonstrated in both colorectal cancer and Ewing’s sarcoma [ 33 , 34 ], and LYN methylation has been observed in some hematopoietic and non-hematopoietic cell lines [ 35 ]. DNA methylation is a molecular modification of DNA that is tightly associated with gene function and cell type-specific gene function [ 36 ].…”
Section: Introductionmentioning
confidence: 99%
“…However, LYN overexpression has been reported in several cancers [ 26 32 ]. In addition, the regulation of LYN by DNA methylation was demonstrated in both colorectal cancer and Ewing’s sarcoma [ 33 , 34 ], and LYN methylation has been observed in some hematopoietic and non-hematopoietic cell lines [ 35 ]. DNA methylation is a molecular modification of DNA that is tightly associated with gene function and cell type-specific gene function [ 36 ].…”
Section: Introductionmentioning
confidence: 99%
“…One study identified that low expression of dCK in pancreatic cancer patients correlated with overall survival as well as age, suggesting a role of age-related methylation of the dCK gene [38]. It was also found that the CDA gene was methylated in an entire cohort of colorectal cancer patient samples, although no correlation was observed between methylation status and clinicopathological parameters [109]. By utilizing microarrays, countless other aberrantly methylated genes have been identified in pancreatic cancer, particularly those related to growth, differentiation, angiogenesis, and apoptotic signaling [110-113].…”
Section: Approaches To Directly Modifying Determinants Of Gemcitabmentioning
confidence: 99%