General optimization strategy of simulated moving bed units through design of experiments and response surface methodologies

Aniceto, José P.S.; Cardoso, Simão P.; Silva, Carlos M.

doi:10.1016/j.compchemeng.2016.04.028

Cited by 29 publications

(18 citation statements)

References 31 publications

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“…7(j)–(l)) represent the cases of initial feed pattern, middle feed pattern and late feed pattern, respectively. The second‐order polynomial correlation 29 as expressed in Eq. (30) was used to describe each surface plot and the associated coefficients are presented in Table 3.…”

Section: Resultsmentioning

confidence: 99%

Enhanced separation of chlorogenic and gallic acids extracted from spent coffee grounds using a three‐zone simulated moving bed process with partial feed and partial collection strategies

Tangpromphan

Nakkong

Jaree

2021

J of Chemical Tech & Biotech

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BACKGROUND Spent coffee grounds, a valuable source of phenolic compounds, are considered beneficial for human health because of their antioxidative properties. The liquid extract containing phenolic compounds (such as chlorogenic and gallic acids) can be obtained via extraction using environmentally friendly organic solvent. The separation of chlorogenic and gallic acids from the liquid extract was carried out using isocratic chromatography technique in a three‐zone simulated moving bed (SMB). However, due to the low selectivity of separation, the productivity of three‐zone SMB was sacrificed to meet the purity criteria. Hence this work aimed to enhance the productivity of three‐zone SMB for the separation of chlorogenic and gallic acids via model simulation using partial feed operation and to improve the concentration of extract and raffinate products using partial collection strategy. RESULTS The full feed scenario was designed based on the triangle theory, and the partial feed patterns (initial feed, middle feed and late feed) were implemented for each operating point in the triangle diagram to investigate the possibility of increasing the feed flow rate. The maximum productivity was evaluated based on the purity criteria (≥98%) for both extract and raffinate products. Under optimal conditions, productivity was doubled to 0.24 mg min−1 L−1 for both middle feed and late feed patterns compared to that of the full feed scenario. The partial collection strategy applied to the optimal point for each operational mode significantly increased the raffinate concentration to approximately 0.02 g L−1 at the optimal time fraction for discarding the solvent. CONCLUSION This work could be a foundation for the valorization of spent coffee ground. © 2021 Society of Chemical Industry (SCI).

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Section: Resultsmentioning

confidence: 99%

Enhanced separation of chlorogenic and gallic acids extracted from spent coffee grounds using a three‐zone simulated moving bed process with partial feed and partial collection strategies

Tangpromphan

Nakkong

Jaree

2021

J of Chemical Tech & Biotech

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“…Recently, simple design approaches were reported to find expressions for performance parameters as functions of control variables [26,42,43]. The standing wave concept was developed for analytic solutions for solvent consumption and productivity in size-exclusive SMB (SEC-SMB) as functions of the material and design parameters [42,43].…”

Section: Boundary Conditionsmentioning

confidence: 99%

“…Speedy standing wave design (SSWD) offers guidelines for designing the operating parameters as well as equipment parameters such as column length, maximum pressure drop, etc. In addition, experimental design and response surface methodology (DoE-RSM) was introduced to optimize the SMB operations [26]. Since DoE-RSM is a statistical tool to evaluate the relationships between independent variables and dependent parameters, purity and productivity are presented as second-degree polynomial functions of the flow rate ratios of zones II and III from data sets of a few simulation runs.…”

Section: Boundary Conditionsmentioning

confidence: 99%

“…In the main part of the review, several selected new variants of the SMB technology, which can significantly expand its potential, are described. This review is not intended as a comprehensive compilation of all options and variants proposed in recent years, as many successful applications have already been reviewed [16,[19][20][21][22][23][24] and more detailed information regarding modeling and controlling SMB can be obtained in the literature [24][25][26][27][28][29]. Accordingly, this review simply introduces and describes the advances, with a focus on introducing novel concepts and providing examples and advantages of recently proposed operating strategies in the following specific SMB areas: manipulations during shifts, altering elution strength, and separation of ternary mixtures (center cut separation).…”

Section: Introductionmentioning

confidence: 99%

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Advanced Operating Strategies to Extend the Applications of Simulated Moving Bed Chromatography

et al. 2017

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Chromatographic separation with solid stationary and fluid mobile phases is widely used to isolate and purify compounds. One of the most productive improvements in preparative chromatography is the simulated moving bed (SMB) process, which enables continuous feed supply and product removal by periodic operation of a multicolumn to simulate a countercurrent flow between the phases. The SMB process produces high‐purity compounds, even with low selectivity, and offers higher productivity and lower eluent consumption than batch chromatography. Recently, intensive efforts have been made to expand the range of applications through the design, modeling, and optimization of the SMB process to produce advanced operating strategies, which are described and evaluated in this review.

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“…Marco Mazzotti first proposed the triangle theory (Mazzotti et al., 1997) under ideal assumptions, ignoring axial dispersion and mass transfer resistance. In recent years, genetic algorithms or particle swarm optimization (PSO) have been used for SMB process design (Aniceto, 2016; Neto et al., 2016). The genetic algorithm requires copy, crossover, and mutation operations, affecting its efficiency.…”

Section: Introductionmentioning

confidence: 99%

Optimizing control of adsorption separation processes based on the improved moving asymptotes algorithm

Yang

Chen

Zhang

2018

Adsorption Science & Technology

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We adopt the orthogonal collocation finite element method to solve an equilibrium diffusion model of a simulated moving bed chromatography separation process. We propose an optimization strategy based on the improved moving asymptotes algorithm to improve system performance indexes. By the triangle theory, we verify the feasibility of the improved moving asymptotes method. The simulation results illustrate that the improved moving asymptotes method converges quickly and results in uniformly distributed optimal solutions. This work aims to show that the simulated moving bed process can be dynamically controlled and optimized using an optimizing controller based on the method of improved moving asymptotes, facilitating the design and operation of a simulated moving bed.

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General optimization strategy of simulated moving bed units through design of experiments and response surface methodologies

Cited by 29 publications

References 31 publications

Enhanced separation of chlorogenic and gallic acids extracted from spent coffee grounds using a three‐zone simulated moving bed process with partial feed and partial collection strategies

Enhanced separation of chlorogenic and gallic acids extracted from spent coffee grounds using a three‐zone simulated moving bed process with partial feed and partial collection strategies

Advanced Operating Strategies to Extend the Applications of Simulated Moving Bed Chromatography

Optimizing control of adsorption separation processes based on the improved moving asymptotes algorithm

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