General Overview of the 14th International Symposium on Stem Cell Therapy and Cardiovascular Innovations

Sanz‐Ruiz, Ricardo; Climent, Andreu Μ.; Fernández‐Santos, María Eugenia; Arranz, Adolfo Villa; Ibañes, Enrique Gutiérrez; Vázquez-Álvarez, María Eugenia; Fernández-Avilés, Francisco

doi:10.1161/circresaha.117.311874

Cited by 4 publications

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“…As knowledge and understanding of cardiac regenerative medicine advances, described as “generational” advances [6–8], refinements are incorporated into design and evaluation of products and delivery methods. Potential products can be evaluated during preclinical stages in vitro or in vivo whereas clinical outcomes are focused on patient outcomes.…”

Section: Designing For Cardiac Regenerative Medicinementioning

confidence: 99%

Enhancement Strategies for Cardiac Regenerative Cell Therapy

Broughton

Sussman

2018

Circulation Research

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The idiom heart of the matter refers to the focal point within a topic and, with regard to health and longevity, the heart is truly pivotal for quality of life. Societal trends worldwide continue toward increased percent body fat and decreased physical activity with coincident increases in chronic diseases including cardiovascular disease as the top global cause of death along with insulin resistance, accelerated aging, cancer. Although long-term survival rates for cardiovascular disease patients are grim, intense research efforts continue to improve both prevention and treatment options. Pharmacological interventions remain the predominant interventional strategy for mitigating progression and managing symptoms, but cellular therapies have the potential to cure or even mediate remission of cardiovascular disease. Adult stem cells are the most studied cellular therapy in both preclinical and clinical investigation. This review will focus on the advanced therapeutic strategies to augment products and methods of delivery, which many think heralds the future of clinical investigations. Advanced preclinical strategies using adult stem cells are examined to promote synergism between preclinical and clinical research, streamline implementation, and improve this imminent matter of the heart.

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Section: Designing For Cardiac Regenerative Medicinementioning

confidence: 99%

Enhancement Strategies for Cardiac Regenerative Cell Therapy

Broughton

Sussman

2018

Circulation Research

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“…The coordination of exosome-mediated communication is important for maintaining physiology, but if altered, it can support disease propagation [46,47]. This dual function can be explained by considering that the amount and quality of exosomes secreted from a cell is influenced by both its activation status and the external environment to which the cell is exposed [48,49], including hypoxia [50].…”

Section: An Introduction To Extracellular Vesiclesmentioning

confidence: 99%

Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac Fibrosis

Tikhomirov

Reilly-O’Donnell

Catapano

et al. 2020

Cells

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Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all forms of heart disease. Cardiac fibroblasts and myofibroblasts are the main effectors of ECM deposition and scar formation. The heart is a complex multicellular organ, where the various resident cell types communicate between themselves and with cells of the blood and immune systems. Exosomes, which are small extracellular vesicles, (EVs), contribute to cell-to-cell communication and their pathophysiological relevance and therapeutic potential is emerging. Here, we will critically review the role of endogenous exosomes as possible fibrosis mediators and discuss the possibility of using stem cell-derived and/or engineered exosomes as anti-fibrotic agents.

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Cardiac Stem Cells: A Plethora of Potential Therapies for Myocardial Regeneration Within Reach

Gallego‐Colon

Oliver

2018

Stem Cell Genetics for Biomedical Research

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General Overview of the 14th International Symposium on Stem Cell Therapy and Cardiovascular Innovations

Cited by 4 publications

References 0 publications

Enhancement Strategies for Cardiac Regenerative Cell Therapy

Enhancement Strategies for Cardiac Regenerative Cell Therapy

Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac Fibrosis

Cardiac Stem Cells: A Plethora of Potential Therapies for Myocardial Regeneration Within Reach

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