For fifth-generation (5G) macrocell mobile-to-mobile (M2M) communication scenarios, we in this article propose a three-dimensional (3D) cylinder multiple-input and multiple-output (MIMO) channel model to reflect the distribution region of interfering objects in macrocell propagation environments, where the receiver (Rx) is located in the center point of the cylinder model, while the transmitter (Tx) is outside the scattering region. In the proposed model, the received signal is constructed as a sum of the components with line-of-sight (LoS) propagations and the components reflected by the objects with different energies, i.e., non-line-of-sight (NLoS) propagation components, which makes the model has the ability to sufficiently adaptable to a variety of 5G wireless communication scenarios. Furthermore, we investigate the statistical channel propagation properties, i.e., spatial cross-correlation functions (CCFs) of two different propagation components, temporal autocorrelation functions (ACFs), and Doppler power spectrum densities (PSDs), for different movement directions and time instants of the Tx and Rx. Numerical analytical results of the propagation properties fit the simulation results very well, which demonstrate that the proposed 3D model is practical for characterizing the real 5G macrocell M2M channels. INDEX TERMS Macrocell MIMO communication environments, 3D cylinder MIMO channel model, LoS propagations, NLoS propagation components, and propagation properties.