Generalized Cutis Laxa Associated with Heavy Chain Deposition Disease

Tan, Stephen; Pon, Kucy; Bargman, Joanne M.; Ghazarian, Danny

doi:10.1177/120347540300700505

Cited by 14 publications

(9 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to renal involvement, the heavy chains may be deposited in the skin and skeletal muscle and has rarely been associated with cutis laxa. 12,13 In our patient, the diagnosis of heavy chain deposition disease was confirmed by noting the presence of IgG-heavy chain deposits in the kidney, the heart, and the skin as demonstrated by immunofluorescence testing.…”

Section: Discussionmentioning

confidence: 74%

See 1 more Smart Citation

Acquired cutis laxa associated with heavy chain deposition disease

Harrington

Beswick

Susa

et al. 2008

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 74%

“…11 The only skin finding that has been reported is cutis laxa. 12,13 In this report, we describe a rare patient with acquired cutis laxa in association with heavy chain deposition disease.…”

mentioning

confidence: 91%

Acquired cutis laxa associated with heavy chain deposition disease

Harrington

Beswick

Susa

et al. 2008

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

“…Multiple myeloma and heavy-chain deposition disease have also been described. 115,116 With the exception of some drug-induced cases, the etiology remains unknown, but cultured fibroblasts show increased elastase activity.…”

Section: Acquired Cutis Laxamentioning

confidence: 99%

The histological and pathogenetic spectrum of cutaneous disease in monoclonal gammopathies

2008

View full text Add to dashboard Cite

The dermatological disorders associated with monoclonal gammopathies are clinically heterogeneous and may be divided into four groups with distinctive pathogenetic mechanisms (a) specific (infiltrative) disorders including primary and secondary cutaneous plasmacytoma and cutaneous lymphoplasmacytic infiltration of Waldenström's disease (b) skin disorders because of the deposition of monoclonal immunoglobulin (M protein), including amyloidoisis macroglobulinemia cutis, light chain deposition of Randall's disease, follicular spicules of the nose, and cryoglobulinemia (c) skin disorders associated with monoclonal gammopathies, including highly associated (>50%), weakly associated (<50%) or anecdotal and (d) miscellaneous (non specific). In most cases, histopathology is crucial to confirm or to diagnose those skin conditions and is also very useful to understand their pathogenetic mechanisms.

show abstract

“…Il peut exister un infiltrat de grandes cellules macrophagiques vacuolisées. Les cas de cutis laxa acquise associés à un myélome ou une gammapathie monoclonale bénigne sont exceptionnels, avec seulement quelques observations dans la littérature [79][80][81][82][83]. Le diagnostic différentiel principal sur le plan histologique est l'élastolyse du derme moyen qui, comme son nom l'indique, se caractérise par une disparition du réseau élastique du derme moyen réticulaire.…”

Section: Cutis Laxa Acquisunclassified