Generalized pustular psoriasis recurring during pregnancy and lactation successfully treated with ixekizumab

Huang, Danyi; Liu, Ting; Jianjian, Li; Lu, Yankun; Ma, Han

doi:10.1111/dth.15878

Cited by 5 publications

(1 citation statement)

References 6 publications

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“…87 These data in terms of efficacy and safety were also confirmed by several case studies. [88][89][90][91] Finally, ixekizumab was found to improve inflammatory markers in patients with GPP with systemic inflammation. 92…”

Section: Ixekizumabmentioning

confidence: 95%

Use of Biological Therapies for the Management of Pustular Psoriasis: A New Era?

Megna¹,

Camela²,

Ruggiero³

et al. 2023

CCID

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Generalized pustular psoriasis (GPP) is a severe and rare form of psoriasis, being a potentially life-threatening condition, characterized by recurring episodes or flares of widespread cutaneous erythema with macroscopic sterile pustules. An irregular innate immune response is linked to GPP, which is considered an auto-inflammatory disorder, while innate and adaptive immunopathogenic responses are involved in psoriasis pathogenesis. In consequence, different cytokine cascades have been suggested to be mainly involved in the pathogenesis of each different psoriasis form, with the interleukin (IL)23/IL17 axis implied in plaque psoriasis, and the IL36 pathway in the GPP. As regards GPP treatment, conventional systemic drugs available for plaque psoriasis are usually used as the first-line treatment option. However, contraindications and adverse events often limit the use of these therapies. In this scenario, biologic drugs may represent a promising treatment option. To date, even if 12 different biologics have been approved for plaque psoriasis, none of these is approved for GPP where they are employed off-label. Recently, spesolimab, an anti-IL36 receptor monoclonal antibody, has been recently approved for GPP. The purpose of this article is to assess the current literature about the use of biological therapies for the treatment of GPP to establish the basis for a shared GPP management algorithm.

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Section: Ixekizumabmentioning

confidence: 95%

Use of Biological Therapies for the Management of Pustular Psoriasis: A New Era?

Megna¹,

Camela²,

Ruggiero³

et al. 2023

CCID

View full text Add to dashboard Cite

show abstract

A guide to prescribing systemic treatments for psoriasis during pregnancy, breastfeeding and in those trying to conceive: what does the current evidence suggest?

Hutchison,

Eraifej,

Moss

et al. 2024

Clinical and Experimental Dermatology

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Psoriasis is a common inflammatory skin condition with an estimated prevalence of 1.5% in the United Kingdom. Its management has evolved rapidly over the last 15 years as our understanding of its pathogenesis has progressed. Treatment initiation often overlaps with peak reproductive years, posing specific therapeutic challenges for individuals hoping to conceive. Certain systemic agents are well-established to be teratogenic during pregnancy, such as methotrexate and acitretin, but data on newer drug classes for psoriasis remains limited. This literature review evaluated recent data on the systemic agents for psoriasis, explicitly considering the context of male and female fertility, pregnancy, and breastfeeding. Our goal was to equip clinicians with an accessible, concise summary of up-to-date evidence to help them educate patients and facilitate informed, shared decision-making aligned with their reproductive health.

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Successful treatment of recurrent generalized pustular psoriasis of pregnancy with ixekizumab: A case report

Özdemir,

Gülengül,

Temirkaynak

et al. 2024

Aust J Dermatology

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Generalized pustular psoriasis recurring during pregnancy and lactation successfully treated with ixekizumab

Cited by 5 publications

References 6 publications

Use of Biological Therapies for the Management of Pustular Psoriasis: A New Era?

Use of Biological Therapies for the Management of Pustular Psoriasis: A New Era?

A guide to prescribing systemic treatments for psoriasis during pregnancy, breastfeeding and in those trying to conceive: what does the current evidence suggest?

Successful treatment of recurrent generalized pustular psoriasis of pregnancy with ixekizumab: A case report

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