Generalized tinea versicolor following initiation of ixekizumab therapy

Alam, Haroon; Ward, Jordan Maxwell; Davis, Loretta S.

doi:10.1016/j.jdcr.2021.10.008

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…On a different note, a study came to the conclusion that blockage of the IL-17 signaling pathway increased the incidence of superficial fungal infections (including three cases with pityriasis versicolor) in psoriatic patients [ 24 ]. Rapid onset of widespread tinea versicolor has been encountered in a psoriatic patient following a switch from ustekinumab to ixekizumab [ 25 ]. Another psoriatic patient on secukinumab was reported to present with atypical oral candidiasis, which improved remarkably following lowering the monthly dose of secukinumab to 150 mg [ 26 ] as well as another case of psoriasis who experienced co-existing chronic hyperplastic candidosis and an oral lichenoid lesion, as side effects of the secukinumab therapy, which the patient was subjected to [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Detection of IL-17A and IL-17F gene polymorphism in recurrent and disseminated pityriasis versicolor: a case-control study

et al. 2022

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Recurrent and disseminated pityriasis versicolor (RDPV) is a common clinical entity, characterized by its recurrent and disfiguring nature. Studies demonstrated host genetic variations in the immune response, especially the role of IL-17 in antifungal immunity. This study aimed to detect whether IL-17A and F gene polymorphisms are found in cases of RDPV. It included 100 cases of RDPV and 100 age and sex matched controls, from which EDTA blood samples were taken for single-nucleotide polymorphism analysis. IL-17A (rs2275913) and F (rs763780) were associated with a significantly increased incidence of developing RDPV. IL-17A and F gene polymorphism could be implicated as a risk factor for the development of RDPV.

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Section: Discussionmentioning

confidence: 99%

Detection of IL-17A and IL-17F gene polymorphism in recurrent and disseminated pityriasis versicolor: a case-control study

et al. 2022

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“…Tinea versicolor is characterized by mildly scaly hypopigmented or hyperpigmented macules/patches, most commonly affecting areas of skin that are rich in sebum production such as the trunk (especially the upper part), neck, shoulders and upper arms (Figures 1-3A). 19,21,24,[67][68][69] Facial involvement is less common in adults. On the other hand, facial involvement is common in children and may be the only site involved (Figure 3B).…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…Predisposing factors for the conversion include a hot and humid environment, hyperhidrosis, application of oily lotion or cream to the skin, wearing of masks, excessive lipid-containing sebaceous secretions, malnutrition, poor general health, use of oral contraceptives, pregnancy, diabetes mellitus, use of topical or systemic corticosteroids, Cushing disease, Helicobacter pylori infection, immunodeficiency and genetic predisposition. [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] A recent study showed oxidative stress has no role in the pathogenesis of tinea versicolor. 29…”

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confidence: 99%

Tinea versicolor: an updated review

Leung¹,

Barankin²,

Lam³

et al. 2022

DIC

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A search was conducted in July 2022 in PubMed Clinical Queries using the key terms "tinea versicolor" OR "pityriasis versicolor". The search strategy included all clinical trials (including open trials, non-randomized controlled trials and randomized controlled trials), observational studies and reviews (including narrative reviews and meta-analyses) published within the past 10 years. Only papers published in the English literature were included in this review. The information retrieved from the search was used in the compilation of this article. Review AetiopathogenesisTinea versicolor is caused by dimorphic lipophilic and lipid-dependent yeasts in the genus Malassezia (formerly known as Pityrosporum) species, notably Malassezia globosa (M. globose), M. furfur and M. sympodialis. [2][3][4][5][6][7][8][9][10][11][12] Other species that have been implicated include M. restricta, M. obtuse, M. slooffiae, M. pachydermatis and M. japonica. [13][14][15][16] These yeasts are normal commensals on the skin surface. 17,18 Skin colonization increases with age; 25% of children and almost 100% of adults are affected. 19 Tinea versicolor occurs when the saprophytic yeast or budding form of the organism converts to the pathogenic hyphal or mycelial form. The fungal infection is localized to the stratum corneum. Predisposing factors for the conversion include a hot and humid environment, hyperhidrosis, application of oily lotion or cream to the skin, wearing of masks, excessive lipid-containing sebaceous secretions, malnutrition, poor general health, use of oral contraceptives, pregnancy, diabetes mellitus, use of topical or systemic corticosteroids, Cushing disease, Helicobacter pylori infection, immunodeficiency and genetic predisposition. [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] A recent study showed oxidative stress has no role in the pathogenesis of tinea versicolor. 29

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