Generating electrospray from solutions predeposited on a copper wire

Hong, Chi-Ming; Lee, Chwan-Tzong; Lee, Yu-Ming; Kuo, C. Mike; Yuan, Cheng-Hui; Shiea, Jentaie

doi:10.1002/(sici)1097-0231(19990115)13:1<21::aid-rcm441>3.0.co;2-7

Cited by 74 publications

(62 citation statements)

References 19 publications

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“…Noncapillary ESI techniques have also been developed. Materials such as wick element [3], copper wire [4], metal needle [5][6][7], optical fiber wired with a metal coil [8,9], surface-modified glass rod [10], nanostructured tungsten oxide [11], and more recently paper [12,13] and wood [14] have been used for sampling and ionization in ESI. Use of noncapillary emitters avoids the problem of clogging that could occur in capillary-based ESI and allows much easier sampling.…”

Section: E Lectrospray Ionization (Esi) Is a Powerful Massmentioning

confidence: 99%

Analytical Properties of Solid-substrate Electrospray Ionization Mass Spectrometry

Yao

2012

J. Am. Soc. Mass Spectrom.

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Abstract. Conventional electrospray ionization mass spectrometry (ESI-MS) uses a capillary for sample loading and ionization. Along with the development of ambient ionization techniques, ESI-MS using noncapillary emitters has attracted more interest in recent years. Following our recent report on ESI-MS using wooden tips (Anal. Chem. 83, 8201-8207 (2011)), the technique was further investigated and extended in this study. Our results revealed that the wooden tips could serve as a chromatographic column for separation of sample components. Sequential and exhaustive ionization was observed for proteins and salts on wooden tips with salts ionized sooner and proteins later. Nonconductive materials that contain microchannels/pores could be used as tips for ESI-MS analysis with sample solutions loaded to the sharp-ends only, since rapid diffusion of sample solutions by capillary action would enable the tips to become conductive. Tips of inert materials such as bamboo, fabrics, and sponge could be used for sample loading and ionization, while samples such as tissue, mushroom, and bone could form tips to induce ionization for direct analysis with application of a high voltage.

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Section: E Lectrospray Ionization (Esi) Is a Powerful Massmentioning

confidence: 99%

Analytical Properties of Solid-substrate Electrospray Ionization Mass Spectrometry

Yao

2012

J. Am. Soc. Mass Spectrom.

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“…33) ey used a thin copper loop to load with sample solution thus electrospray was readily generated. 33) e present study shed light on the possibility that ESI could be generated in a fast and simple way.…”

Section: Esi Emitter Solid Metal Substratesmentioning

confidence: 99%

Electrospray Modifications for Advancing Mass Spectrometric Analysis

Meher

Chen

2017

Mass Spectrometry

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Generation of analyte ions in gas phase is a primary requirement for mass spectrometric analysis. One of the ionization techniques that can be used to generate gas phase ions is electrospray ionization (ESI). ESI is a so ionization method that can be used to analyze analytes ranging from small organics to large biomolecules. Numerous ionization techniques derived from ESI have been reported in the past two decades.ese ion sources are aimed to achieve simplicity and ease of operation. Many of these ionization methods allow the exibility for elimination or minimization of sample preparation steps prior to mass spectrometric analysis. Such ion sources have opened up new possibilities for taking scienti c challenges, which might be limited by the conventional ESI technique. us, the number of ESI variants continues to increase. is review provides an overview of ionization techniques based on the use of electrospray reported in recent years. Also, a brief discussion on the instrumentation, underlying processes, and selected applications is also presented.

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“…65,66) While conventional ESI and nanoESI use metal or glass capillaries, several designs of electrospray ion sources that used non-capillary probes had been put forward. Shiea et al electrosprayed sample solutions deposited on a copper wire ring, 67) optical bers coiled with copper or platinum wires, 68) a glass rod, 69) and nanostructured tungsten oxide 70) and mass spectra of proteins similar to those of conventional ESI were obtained. In 2007, probe electrospray ionization (PESI) using a sharp metal needle as an electrospray emitter was developed in our laboratory.…”

Section: Probe Electrospray Ionizationmentioning

confidence: 99%

Desorption in Mass Spectrometry

et al. 2017

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In mass spectrometry, analytes must be released in the gas phase. ere are two representative methods for the gasi cation of the condensed samples, i.e., ablation and desorption. While ablation is based on the explosion induced by the energy accumulated in the condensed matrix, desorption is a single molecular process taking place on the surface. In this paper, desorption methods for mass spectrometry developed in our laboratory: ash heating/rapid cooling, Leidenfrost phenomenon-assisted thermal desorption (LPTD), solid/solid friction, liquid/solid friction, electrospray droplet impact (EDI) ionization/desorption, and probe electrospray ionization (PESI), will be described. All the methods are concerned with the surface and interface phenomena. e concept of how to desorb less-volatility compounds from the surface will be discussed.Copyright © 2017 Dilshadbek Tursunbayevich Usmanov, Satoshi Ninomiya, Lee Chuin Chen, Subhrakanti Saha, Mridul Kanti Mandal, Yuji Sakai, Rio Takaishi, Ahsan Habib, Kenzo Hiraoka, Kentaro Yoshimura, Sen Takeda, Hiroshi Wada, and Hiroshi Nonami. is is an open access article distributed under the terms of Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.Please cite this article as: Mass Spectrom (Tokyo) 2017; 6(2): S0059 Keywords: desorption, ablation, thermal desorption, Leidenfrost phenomenon, ash heating, electrospray droplet impact ionization, probe electrospray ionization (Received September 20, 2016; Accepted January 4, 2017) RATIONALE: ABLATION VS. DESORPTION e two technical terms, ablation and desorption, should be distinguished rigorously. As shown in Fig. 1, ablation is induced by explosion of the matrix or substrate whereas desorption is a single molecular event, i.e., detachment of a single molecule from the surface. e antonym of desorption is adsorption.In matrix assisted laser desorption/ionization (MALDI), for example, the photon energy is ultimately converted to thermal energy and ablation of the matrix takes place above the critical laser power (Fig. 1(a)). In ablation, the ablated materials are mainly composed of aggregates. us the ions observed in MALDI are only a small part of materials ablated. In this respect, MALDI is more likely matrixassisted laser "ablation" ionization. In secondary ion mass spectrometry (SIMS), primary projectiles such as Ar, and (Ar) n + are used. In SIMS using atomic ion projectiles, the sputtering is caused by the cascade collisions in the sample. us the useful yield de ned as [total gas phase ions detected] divided by [total amount of sample sputtered] is rather low. e small useful yields for MALDI and SIMS (10 −5 -10) originate from the fact that photons or primary beams penetrate into the target materials leading to the sputtering of the substrate. In contrast, the useful yield for desorption-based techniques could be much higher than MALDI and SIMS if the desorbed molecules are ionized by high-e cien...

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Generating electrospray from solutions predeposited on a copper wire

Cited by 74 publications

References 19 publications

Analytical Properties of Solid-substrate Electrospray Ionization Mass Spectrometry

Analytical Properties of Solid-substrate Electrospray Ionization Mass Spectrometry

Electrospray Modifications for Advancing Mass Spectrometric Analysis

Desorption in Mass Spectrometry

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