Generation of polycyclic aromatic hydrocarbons (PAHs) during woodworking operations

Bruschweiler, Evin Danisman; Danuser, Brigitta; Huynh, Cong Khanh; Wild, Pascal; Schüpfer, Patrick; Vernez, David; Boiteux, Philippe; Hopf, Nancy B.

doi:10.3389/fonc.2012.00148

Cited by 20 publications

(14 citation statements)

References 22 publications

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“…When wood workers manipulate wood melamine using power tools, PAHs are generated as shown in our previous study. 16 Total PAH concentrations decreased in the following order of wood dust collected after use of different power tools under controlled conditions: wood melamine . oak .…”

Section: Discussionmentioning

confidence: 98%

DNA Damage among Wood Workers Assessed with the Comet Assay

Bruschweiler

Wild

Huynh

et al. 2016

Environ�Health�Insights

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Exposure to wood dust, a human carcinogen, is common in wood-related industries, and millions of workers are occupationally exposed to wood dust worldwide. The comet assay is a rapid, simple, and sensitive method for determining DNA damage. The objective of this study was to investigate the DNA damage associated with occupational exposure to wood dust using the comet assay (peripheral blood samples) among nonsmoking wood workers (n = 31, furniture and construction workers) and controls (n = 19). DNA damage was greater in the group exposed to composite wood products compared to the group exposed to natural woods and controls (P < 0.001). No difference in DNA damage was observed between workers exposed to natural woods and controls (P = 0.13). Duration of exposure and current dust concentrations had no effect on DNA damage. In future studies, workers’ exposures should include cumulative dust concentrations and exposures originating from the binders used in composite wood products.

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Section: Discussionmentioning

confidence: 98%

DNA Damage among Wood Workers Assessed with the Comet Assay

Bruschweiler

Wild

Huynh

et al. 2016

Environ�Health�Insights

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“…The International Agency for Research on Cancer has classified wood dust as carcinogenic to humans based on the strong associations between SNC and wood dust exposures identified in several epidemiological studies (Group 1) (10). Wood dust particles generated during woodworking operations are composed mainly of largest particles (>10 µm) (11)(12)(13). Largest wood particles are known to deposit in the sino-nasal region, making the nose the target organ (14).…”

Section: Introductionmentioning

confidence: 99%

Workers exposed to wood dust have an increased micronucleus frequency in nasal and buccal cells: results from a pilot study

et al. 2014

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Wood dust is recognised as a human carcinogen, based on the strong association of wood dust exposure and the elevated risk of malignant tumours of the nasal cavity and paranasal sinuses [sino-nasal cancer (SNC)]. The study aimed to assess genetic damage in workers exposed to wood dust using biomarkers in both buccal and nasal cells that reflect genome instability events, cellular proliferation and cell death frequencies. Nasal and buccal epithelial cells were collected from 31 parquet layers, installers, carpenters and furniture workers (exposed group) and 19 non-exposed workers located in Switzerland. Micronucleus (MN) frequencies were scored in nasal and buccal cells collected among woodworkers. Other nuclear anomalies in buccal cells were measured through the use of the buccal micronucleus cytome assay. MN frequencies in nasal and buccal cells were significantly higher in the exposed group compared to the non-exposed group; odds ratio for nasal cells 3.1 [95% confidence interval (CI) 1.8-5.1] and buccal cells 1.8 (95% CI 1.3-2.4). The exposed group had higher frequencies of cells with nuclear buds, karyorrhectic, pyknotic, karyolytic cells and a decrease in the frequency of basal, binucleated and condensed cells compared to the non-exposed group. Our study confirms that woodworkers have an elevated risk for chromosomal instability in cells of the aerodigestive tract. The MN assay in nasal cells may become a relevant biomonitoring tool in the future for early detection of SNC risk. Future studies should seek to standardise the protocol for MN frequency in nasal cells similar to that for MN in buccal cells.

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“…Therefore, the PAH load in road dust in Surfers Paradise is lower than in Benowa. The high load of PAHs in road dust in Nerang is attributed to the numerous industrial activities such as painting, timber processing and furniture manufacturing in the area which can generate significant PAH loads (Dong and Lee, 2009;Wang et al, 2011;Bruschweiler et al, 2012;Kho et al, 2014). These results suggested that since areas with vehicle related business activities, high traffic volume and industrial activities can lead to high PAH loads and hence could pose higher risks.…”

Section: Analysis Of Pahs On Urban Roads In Gold Coastmentioning

confidence: 98%

Quantitative assessment of human health risk posed by polycyclic aromatic hydrocarbons in urban road dust

Liu

Egodawatta

et al. 2017

Science of The Total Environment

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Editor: Adrian CovaciAmong the numerous pollutants present in urban road dust, polycyclic aromatic hydrocarbons (PAHs) are among the most toxic chemical pollutants and can pose cancer risk to humans. The primary aim of the study was to develop a quantitative model to assess the cancer risk from PAHs in urban road dust based on traffic and land use factors and thereby to characterise the risk posed by PAHs in fine (b150 μm) and coarse (N 150 μm) particles. The risk posed by PAHs was quantified as incremental lifetime cancer risk (ILCR), which was modelled as a function of traffic volume and percentages of different urban land uses. The study outcomes highlighted the fact that cancer risk from PAHs in urban road dust is primarily influenced by PAHs associated with fine solids. Heavy PAHs with 5 to 6 benzene rings, especially dibenzo [a,h]

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Generation of polycyclic aromatic hydrocarbons (PAHs) during woodworking operations

Cited by 20 publications

References 22 publications

DNA Damage among Wood Workers Assessed with the Comet Assay

DNA Damage among Wood Workers Assessed with the Comet Assay

Workers exposed to wood dust have an increased micronucleus frequency in nasal and buccal cells: results from a pilot study

Quantitative assessment of human health risk posed by polycyclic aromatic hydrocarbons in urban road dust

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