Genes and structure of selected cytokines involved in pathogenesis of psoriasis.

Pietrzak, Aldona; Zalewska, Anna; Chodorowska, Grażyna; Nockowski, Piotr; Michalak-Stoma, Anna; Osemlak, Paweł; Krasowska, Dorota

doi:10.2478/v10042-008-0002-y

Cited by 19 publications

(10 citation statements)

References 138 publications

(112 reference statements)

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“…Complex pathophysiology of psoriasis includes cooperation between keratinocytes of epidermis, T lymphocytes and endothelial cells. With regard to ethiopathogenesis, it is classified as the inflammatory disease through a strong and inseparable relationship with the immunological system, which translates into an increased concentration of pro-inflammatory cytokines [ 27 – 36 ].…”

Section: Discussionmentioning

confidence: 99%

Variances in the mRNA expression profile of TGF-β1–3 isoforms and its TGF-βRI–III receptors during cyclosporin a treatment of psoriatic patients

Michalska-Bańkowska

Wcisło‐Dziadecka

Grabarek

et al. 2018

pdia

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IntroductionPsoriasis is a chronic, immunologic, multi-factor inflammatory skin disease, strongly associated with a higher level of a number of cytokines, such as isoforms of transforming growth factor β (TGF-β1–3) and its receptors (TGF-βRI–III). One of the most popular and important drugs used to treat this disease is cyclosporin A (CsA).AimThe aim of this study was to investigate the expression of genes encoding the transforming growth factor (TGF)-β isoforms and receptors of the cytokine TGF-βRs in psoriatic patients during an 84-day long observation of the effects of cyclosporin A therapy. It made an attempt to determine the usefulness of testing mRNA expression of TGF-β1–3 and its receptors TGF-βRI–III as the supplementary molecular markers of lost sensitivity to the medicine.Material and methodsThe study group consisted of 32 patients with psoriasis (20 men and 12 women) treated with cyclosporin A. The changes in expression patterns of TGF-β1-3 and TGF-βRI-III were performed by real-time quantitative reverse transcription PCR (RTqPCR).ResultsThe expression of TGF-β1-3 and TGF-βRI-III were detected in the whole period of therapy with CsA. Changes in transcriptional activities of TGF-β1–3 and TGF-βRI–III during pharmacotherapy were observed. Differences in the expression of these genes were found before and after 42 and 84 days of using CsA.ConclusionsThe changes in expression profiles of TGF-β1-3 and TGF-βRI-III during CsA therapy can be a useful molecular marker of lost sensitivity to the medicine.

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Section: Discussionmentioning

confidence: 99%

Variances in the mRNA expression profile of TGF-β1–3 isoforms and its TGF-βRI–III receptors during cyclosporin a treatment of psoriatic patients

Michalska-Bańkowska

Wcisło‐Dziadecka

Grabarek

et al. 2018

pdia

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“…Psoriasis is characterized by inflamed lesions covered with silvery-white scabs of dead skin. The following cytokines are directly involved in psoriasis: TNF, IL-1, IL-2, IL-6, IL-7, IL-8, IL-15, IL-18, IL-19, IL-20, IL-23 whereas IL-4, IL-10, IL-12 as well as IL-11, IL-17 and IFN-gamma are rather indirectly engaged [91]. Psoriatic arthritis is an inflammatory arthritis associated with psoriasis.…”

Section: Cyclic Ichthyosis With Epidermolytic Hyperkeratosis (Also Knmentioning

confidence: 99%

Unfoldomics of Human Genetic Diseases: Illustrative Examples of Ordered and Intrinsically Disordered Members of the Human Diseasome

Midic

Oldfield

Dunker³

et al. 2009

PPL

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“…Interleukin (IL)-6 is a glycoprotein of 21–28 kDa molecular weight and consists of 184 amino acids [5]. IL-6 is a pleiotropic cytokine that plays a central role in hematopoiesis, as well as in the differentiation and growth of a number of cells of different histologic origin, e.g.…”

Section: Introductionmentioning

confidence: 99%

Relevance of Serum Levels of Interleukin-6 and Syndecan-1 in Patients with Hepatocellular Carcinoma

Metwaly

2012

Sci. Pharm.

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Syndecan-1 is a trans-membrane heparan sulfate proteoglycan that localizes in epithelial cells and has been shown to be present in normal hepatocytes. It is thought to be involved in processes such as cell growth, differentiation and adhesion. However, the clinical data regarding syndecan-1 in patients with hepatocellular carcinoma (HCC) are scarce and controversial. Therefore, we need to evaluate the effects of HCC on the serum levels of syndecan-1. Thus, 40 patients with HCC and 31 patients with liver cirrhosis were physically examined. Blood samples were taken for measurements of routine markers (sGPT, sGOT, bilirubin, albumin, and α-fetoprotein), as well as serum levels of interleukin (IL)-6 and syndecan-1. Patients with liver cirrhosis showed significant increase in serum IL-6 as compared with HCC patients and the control subjects. Serum level of syndecan-1 was significantly increased in HCC patients as compared with the cirrhotic and control groups. In addition, significant positive correlations between syndecan-1 and serum levels of ALT, AST in HCC patients were found. Moreover, syndecan-1 increased significantly with increasing stage of Barcelona-Clinic Liver Cancer Group diagnostic and treatment strategy. In conclusion, the development of HCC is accompanied by a significant elevation in serum syndecan-1 levels. The increase in serum syndecan-1 may be linked with progression of HCC.

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Genes and structure of selected cytokines involved in pathogenesis of psoriasis.

Cited by 19 publications

References 138 publications

Variances in the mRNA expression profile of TGF-β1–3 isoforms and its TGF-βRI–III receptors during cyclosporin a treatment of psoriatic patients

Variances in the mRNA expression profile of TGF-β1–3 isoforms and its TGF-βRI–III receptors during cyclosporin a treatment of psoriatic patients

Unfoldomics of Human Genetic Diseases: Illustrative Examples of Ordered and Intrinsically Disordered Members of the Human Diseasome

Relevance of Serum Levels of Interleukin-6 and Syndecan-1 in Patients with Hepatocellular Carcinoma

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