Genes Related to Economically Important Traits in Beef Cattle

Hirwa, Claire d’Andre; Wallace, Paul A. W.; Shen, Xu; Nie, Qinghua; Guanfu, Yang; Zhang, Xiquan

doi:10.3923/ajas.2011.34.45

Cited by 19 publications

(7 citation statements)

References 23 publications

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“…This result also does not correlate with greater or lesser content of intramuscular fat in the muscle of these animals. The role of the C/EBP family of transcription factors in the preadipocyte differentiation process has been well described in farm animals (Kersten et al, 2000;Wang et al, 2009;Hirwa et al, 2010). Wang et al (2009) analysed the pattern of expression in the intramuscular fat and observed that the mRNA expression of CCAT/enhancer binding protein beta (C/EBPb) was relatively greater at early time points.…”

Section: Scdmentioning

confidence: 97%

Differentially transcribed genes in skeletal muscle of lambs

et al. 2012

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a b s t r a c tThe objective of this study was to compare gene transcription profiles in Longissimus dorsi muscle of the following four hair sheep genetic groups, Morada Nova (MO), Brazilian Somali (SO), Santa Inês (SI) and ½Dorper Â ½Morada Nova (F1). These groups all display different postnatal muscle growth. The transcriptomes of the skeletal muscle of the lambs (at 200 days of age) were profiled by using oligonucleotide microarrays and reverse transcriptionquantitative real-time PCR (RT-qPCR). The microarray experiment identified 262 transcripts that were differentially expressed when transcription levels were compared between the different breeds. A total of 23 transcripts among which those involved in skeletal muscle development (MyoD1 and IGFBP4), lipogenesis and adipogenesis (C/EBPd, PPARg and PGDS) were differentially expressed in at least in one comparison. Clustering analysis showed that there is greater similarity in gene expression between the MO and SI breeds and between F1 and SO genetic groups. The SO breed has the most distinct expression pattern. The RT-qPCR results confirmed the findings from the microarray study. A positive correlation was observed between the expression of MyoD1 and the cold carcass yield. The negative correlations between the weight and yield of cold carcass with the expression of C/EBPd mean that the selection for adipogenesis could lead to a lower carcass weight. The GLUT3 and PYGL gene transcripts were negatively correlated with fat thickness, but ATP5G1 was positively correlated with this trait. Interestingly, many genes negatively correlated with PUFA were positively correlated with cold carcass yield. In conclusion, the present work demonstrated that there are breed-specific expression patterns in Brazilian hair sheep genetic groups. The differences in gene expression among genetic groups were consistent with their phenotypic differences. The positive correlation of the MyoD1 expression with the cold carcass yield suggests that this gene is important for tissue growth in sheep. The positive correlation of the C/EBPd expression with PUFA provides an opportunity to select for lipid deposition in meat animals.

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Section: Scdmentioning

confidence: 97%

Differentially transcribed genes in skeletal muscle of lambs

et al. 2012

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“…However, application of DNA markers to improve these traits through marker-assisted selection (MAS) is shown to be a powerful and efficient strategy (Pedersen et al, 2009), and there are some commercially available markers for beef meat quality (Gao et al, 2007). Consequently, it would be reasonable to place considerable emphasis on sifting out numerous candidate genes and elaborating the significant associations between their genetic variations with body measurement and meat quality traits (Hirwa et al, 2011;Ribeca et al, 2014).…”

Section: Introductionmentioning

confidence: 98%

Association study and expression analysis of MTNR1A as a candidate gene for body measurement and meat quality traits in Qinchuan cattle

Wang

Zan

2015

Gene

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“…GH polymorphism studies found that one allele of a GH genotype was associated with increased BF only in heifers (171), whereas THRSP was highly correlated with IM development and CRH was highly associated with BF (169). As in porcine studies, FABP4 increased BF and also influenced IM (169). In contrast to pig studies, in a study involving large numbers of cattle, a LEP SNP was associated with markedly increased BF (172).…”

Section: Identification Of Genes Influencing Adipose Tissue Differentmentioning

confidence: 68%

“…DNA-PK may indirectly influence lipid metabolism through transcription of FAS (173). GH polymorphism studies found that one allele of a GH genotype was associated with increased BF only in heifers (171), whereas THRSP was highly correlated with IM development and CRH was highly associated with BF (169). As in porcine studies, FABP4 increased BF and also influenced IM (169).…”

Section: Identification Of Genes Influencing Adipose Tissue Differentmentioning

confidence: 90%

Preadipocyte and Adipose Tissue Differentiation in Meat Animals: Influence of Species and Anatomical Location

Hausman¹,

Basu

Wei

et al. 2014

Annu. Rev. Anim. Biosci.

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Early in porcine adipose tissue development, the stromal-vascular (SV) elements control and dictate the extent of adipogenesis in a depot-dependent manner. The vasculature and collagen matrix differentiate before overt adipocyte differentiation. In the fetal pig, subcutaneous (SQ) layer development is predictive of adipocyte development, as the outer, middle, and inner layers of dorsal SQ adipose tissue develop and maintain layered morphology throughout postnatal growth of SQ adipose tissue. Bovine and ovine fetuses contain brown adipose tissue but SQ white adipose tissue is poorly developed structurally. Fetal adipose tissue differentiation is associated with the precocious expression of several genes encoding secreted factors and key transcription factors like peroxisome proliferator activated receptor (PPAR)γ and CCAAT/-enhancer-binding protein. Identification of adipocyte-associated genes differentially expressed by age, depot, and species in vivo and in vitro has been achieved using single-gene analysis, microarrays, suppressive subtraction hybridization, and next-generation sequencing applications. Gene polymorphisms in PPARγ, cathepsins, and uncoupling protein 3 have been associated with back fat accumulation. Genome scans have mapped several quantitative trait loci (QTL) predictive of adipose tissue-deposition phenotypes in cattle and pigs.

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Genes Related to Economically Important Traits in Beef Cattle

Cited by 19 publications

References 23 publications

Differentially transcribed genes in skeletal muscle of lambs

Differentially transcribed genes in skeletal muscle of lambs

Association study and expression analysis of MTNR1A as a candidate gene for body measurement and meat quality traits in Qinchuan cattle

Preadipocyte and Adipose Tissue Differentiation in Meat Animals: Influence of Species and Anatomical Location

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