2006
DOI: 10.1534/genetics.106.057000
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Genes That Control Ray Sensory Neuron Axon Development in the Caenorhabditis elegans Male

Abstract: We have studied how a set of male-specific sensory neurons in Caenorhabditis elegans establish axonal connections during postembryonic development. In the adult male, 9 bilateral pairs of ray sensory neurons innervate an acellular fan that serves as a presumptive tactile and olfactory organ during copulation. We visualized ray axon commissures with a ray neuron-specific reporter gene and studied both known and new mutations that affect the establishment of connections to the pre-anal ganglion. We found that th… Show more

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Cited by 23 publications
(24 citation statements)
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“…We therefore examined development of ray neurons in daf-12 mutants and observed abnormalities in axonal outgrowth. Ray neurons are born and differentiate during the L4 larval stage, at which time they send out axonal processes through commissures from the lumbar ganglia into the pre-anal ganglion (Sulston et al 1980;Jia and Emmons 2006). In 37% of daf-12(m20) and 21% of daf-12(m583) mutants ray neuron axons showed guidance defects while following commissures to the pre-anal ganglion (data not shown).…”
Section: Resultsmentioning
confidence: 95%
See 1 more Smart Citation
“…We therefore examined development of ray neurons in daf-12 mutants and observed abnormalities in axonal outgrowth. Ray neurons are born and differentiate during the L4 larval stage, at which time they send out axonal processes through commissures from the lumbar ganglia into the pre-anal ganglion (Sulston et al 1980;Jia and Emmons 2006). In 37% of daf-12(m20) and 21% of daf-12(m583) mutants ray neuron axons showed guidance defects while following commissures to the pre-anal ganglion (data not shown).…”
Section: Resultsmentioning
confidence: 95%
“…The presence of daf-12 was verified by testing their inability to form dauers on crowded starved plates at 25°. A number of the lines used in this article carried the integrated transgenic construct bxIs14, which is a pkd-2TGFP fusion construct integrated into chromosome V ( Jia and Emmons 2006), which allowed both ray axon guidance and leaving behavior to be scored. Neither bxIs14 (L. Jia, personal communication) nor him-5 ( J. Lipton, personal communication) affects male leaving behavior.…”
Section: Methodsmentioning
confidence: 99%
“…The axon guidance of various neuronal types, including DD and VD motor neurons, the PVM touch neuron, and the male ray neurons, was defective in fli-1 mutants. For example, in 33% of the fli-1 mutants (n ¼ 16), the axon trajectory followed by ray 1 B-type neuron (R1B), labeled by pkd-2Tgfp, failed to make the turn around the body, but continued to migrate to the anterior ( Figure 5, I and J) ( Jia and Emmons 2006). Therefore, fli-1 plays essential roles in controlling the migration of cells and neuronal axons.…”
Section: Resultsmentioning
confidence: 99%
“…These are broadly defined as the "furry" family of proteins, after a Drosophila melanogaster ortholog involved in the organization of cellular extensions such as bristles, wing hairs, and aristal laterals (Cong et al 2001;He et al 2005;. Like the Ndr kinases, furry-related proteins are also involved in neuron morphogenesis (Zallen et al 1999;Emoto et al 2004;Gallegos and Bargmann 2004;Jia and Emmons 2006;Gao 2007). Phylogenetic analysis of these putative Tao3 orthologs indicates that the broad family has five sequence blocks that exhibit significant conservation from metazoans to yeast, and that a significant portion of the protein has HEAT repeats predicted to adopt an extended b-catenin-like structure (Gallegos and Bargmann 2004;Chiba et al 2009;Goto et al 2010) Sog2 is a leucine-rich protein that interacts with Kic1 and most likely with Tao3 and localizes to the cell cortex (Nelson et al 2003).…”
Section: Ram Networkmentioning
confidence: 99%