Genetic and Developmental Modulation of Cardiac Deficits in Prenatal Alcohol Exposure

Cavieres, María Fernanda; Smith, Susan

doi:10.1097/00000374-200001000-00015

Cited by 18 publications

(20 citation statements)

References 20 publications

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“…2(e)-2(h)], in agreement with a study on quail. 54 The reduction in TA size that is reported in this work was predicted by Cavierres and Smith, 55 but not observed. To our knowledge, less developed ventricular trabeculae caused by ethanol exposure [Figs.…”

Section: Discussionsupporting

confidence: 51%

Multimodality optical imaging of embryonic heart microstructure

Yelin

et al. 2007

J. Biomed. Opt.

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Study of developmental heart defects requires the visualization of the microstructure and function of the embryonic myocardium, ideally with minimal alterations to the specimen. We demonstrate multiple endogenous contrast optical techniques for imaging the Xenopus laevis tadpole heart. Each technique provides distinct and complementary imaging capabilities, including: 1. 3-D coherence microscopy with subcellular (1 to 2 µm) resolution in fixed embryos, 2. real-time reflectance confocal microscopy with large penetration depth in vivo, and 3. ultra-high speed (up to 900 frames per second) that enables real-time 4-D high resolution imaging in vivo. These imaging modalities can provide a comprehensive picture of the morphologic and dynamic phenotype of the embryonic heart. The potential of endogenous-contrast optical microscopy is demonstrated for investigation of the teratogenic effects of ethanol. Microstructural abnormalities associated with high levels of ethanol exposure are observed, including compromised heart looping and loss of ventricular trabecular mass.

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Section: Discussionsupporting

confidence: 51%

Multimodality optical imaging of embryonic heart microstructure

Yelin

et al. 2007

J. Biomed. Opt.

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“…The depth and scope of present study do not allow further speculations on the causes of this finding, but reports in the literature point out that the effects of ethanol exposure on different persons may be modulated by many factors, among them, their genetic background (33).…”

Section: Discussionmentioning

confidence: 68%

Effects of Light Ethanol Consumption During Pregnancy: Increased Frequency of Minor Anomalies in the Newborn and Altered Contractility of Umbilical Cord Artery

et al. 2007

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This study explores the effects of light maternal ethanol consumption during pregnancy on the appearance of minor malformations in neonates as well as on the contractile properties of their umbilical cord arteries (UCAs). Clinical external findings of newborns of women declaring light ethanol consumption during any period of their pregnancies [ethanol-exposed group (E group), n ϭ 79] were compared with those of nonexposed mothers [nonexposed to ethanol group (NE group), n ϭ 100]. Women who smoked or had any associated pathology were excluded. E group mothers consumed, on average, 200 -250 mL ethanol/trimester (upper limit 700 mL/ trimester). Sixty-six percent of the neonates in the E group presented at least one minor malformation (retromicrognathia and minor anomalies of the auricular/preauricular area were the more common), whereas only 16% of the NE group did (p ϭ 0.0000). The percentage of children exhibiting Apgar scores Ͻ7 was significantly greater in the E group (11% versus 2%, p ϭ 0.0119). UCAs from the E group developed significantly less contractile force (p Ͻ 0.05) than those of the NE group when exposed to 1 M serotonin (5-HT) or to a high K ϩ depolarizing solution. This difference persisted after inhibition of endothelial release of nitric oxide (NO) and prostacyclin. In conclusion, even light drinking should be considered a risk during pregnancy. (Pediatr Res 61: 456-461, 2007)

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“…83 Studies in mice, chick, and zebrafish show that different strains have different sensitivities to ethanol-induced defects. 33,34,[84][85][86] However, direct analysis of the genetic loci regulating sensitivity to ethanolinduced birth defects is still in its infancy. Only a handful of gene-ethanol interactions have been identified to date.…”

Section: Identifying Gene-ethanol Interactions: the Way Of The Fishmentioning

confidence: 99%

Fishing for Fetal Alcohol Spectrum Disorders: Zebrafish as a Model for Ethanol Teratogenesis

2016

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Fetal Alcohol Spectrum Disorders (FASD) describes a wide array of ethanol-induced developmental defects, including craniofacial dysmorphology and cognitive impairments. It affects *1 in 100 children born in the United States each year. Due to the pleiotropic effects of ethanol, animal models have proven critical in characterizing the mechanisms of ethanol teratogenesis. In this review, we focus on the utility of zebrafish in characterizing ethanolinduced developmental defects. A growing number of laboratories have focused on using zebrafish to examine ethanol-induced defects in craniofacial, cardiac, ocular, and neural development, as well as cognitive and behavioral impairments. Growing evidence supports that genetic predisposition plays a role in these ethanol-induced defects, yet little is understood about these gene-ethanol interactions. With a high degree of genetic amenability, zebrafish is at the forefront of identifying and characterizing the gene-ethanol interactions that underlie FASD.

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Genetic and Developmental Modulation of Cardiac Deficits in Prenatal Alcohol Exposure

Abstract: Results add to the increasing evidence that genetic background strongly modulates the effects of prenatal alcohol exposure. The results also suggest that embryos have a varying capacity to repair and recover from earlier neural crest losses.

Cited by 18 publications

References 20 publications

Multimodality optical imaging of embryonic heart microstructure

Multimodality optical imaging of embryonic heart microstructure

Effects of Light Ethanol Consumption During Pregnancy: Increased Frequency of Minor Anomalies in the Newborn and Altered Contractility of Umbilical Cord Artery

Fishing for Fetal Alcohol Spectrum Disorders: Zebrafish as a Model for Ethanol Teratogenesis

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