Genetic and environmental interrelations between measurements of thyroid function in a healthy Danish twin population

Hansen, Pia Skov; Brix, Thomas Heiberg; Iachine, Ivan A.; Sørensen, Thorkild I. A.; Kyvik, Kirsten Ohm; Hegedűs, László

doi:10.1152/ajpendo.00321.2006

Cited by 37 publications

(35 citation statements)

References 20 publications

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“…The physiological basis of the set point of this axis is poorly understood (6). Twin studies demonstrate a moderately strong genetic influence (7,8,9,10,11). In recent years, several of the genes involved in this regulation have been identified, with common genetic variation in phosphodiesterase 8B (PDE8B), TSH receptor (TSHR), deiodinase 1 (DIO1), and capping protein muscle Z-line beta (CAPZB) being associated with circulating THs (12,13,14,15,16,17,18,19,20,21,22).…”

Section: Introductionmentioning

confidence: 99%

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Heredity and lifestyle in the determination of between-subject variation in thyroid hormone levels in euthyroid men

Roef¹,

Taes

Toye

et al. 2013

European Journal of Endocrinology

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Objective: Variation in thyroid hormone (TH) concentrations between subjects is greater than in a single subject over a prolonged period of time, suggesting an individual set point for thyroid function. We have previously shown that TH levels within normal range are associated with clinical indices such as bone mass, BMI, and heart rate. The aim of this study on young men was therefore to gain insight into the determinants of variation in TH levels among healthy subjects. Methods: Healthy male siblings (nZ941, 25-45 years) were recruited in a cross-sectional, populationbased study; a history or treatment of thyroid disease and thyroid auto-immunity were exclusion criteria. A complete assessment of TH status was performed (TSH, free thyroxine (FT 4 ), free triiodothyronine (FT 3 ), thyroperoxidase, and thyroglobulin antibodies, reverse T 3 (rT 3 ), thyroidbinding globulin (TBG), and urinary iodine levels). Genotyping was performed by TaqMan and KASP (KBiosciences) genotyping assays. Results: (F)T 4 , rT 3 , and TBG had heritability estimates between 80 and 90%. Estimates were lower for (F)T 3 (60%) and lowest for TSH (49%). Significant associations were observed between different single-nucleotide polymorphisms (SNPs) in the thyroid pathway and TSH, FT 4 , ratio FT 3 :FT 4 , and rT 3 . Nevertheless, these SNPs only explain a limited part of the heredity. As to age and lifestyle-related factors, (F)T 3 was negatively related to age and education level, positively to smoking and BMI (all P!0.0001) but not substantially to urinary iodine concentrations. Smoking was also negatively related to TSH and positively to FT 4 . Conclusion: Both genetic and lifestyle-related factors play a role in determining between-subject variation in TH levels in euthyroid young men, although genetic factors seem most important.

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Section: Introductionmentioning

confidence: 99%

“…Few studies have investigated genetic together with lifestyle-related determinant factors of thyroid function (8,11). This study therefore investigates the contribution of genetics, i.e.…”

Section: Introductionmentioning

confidence: 99%

Heredity and lifestyle in the determination of between-subject variation in thyroid hormone levels in euthyroid men

Roef¹,

Taes

Toye

et al. 2013

European Journal of Endocrinology

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“…However, the fact that thyroid function appears to be sensitive to selenium supplementation adds to the incentive for investigating its effects on multifactorially regulated traits, such as thyroid function (19,41), size (42,43), and autoimmunity (44) in autoimmune thyroid diseases, where selenoprotein biosynthesis may be impaired (18). A number of trials in Hashimoto's thyroiditis have thus far not clarified the role of selenium supplementation (39).…”

Section: Discussionmentioning

confidence: 99%

“…The analyses were performed on AutoDELFIA equipment (Wallac, Turku, Finland) and LOD was 1.5 pmol/l (FT 3 ), 2 pmol/l (FT 4 ), and 1 mIU/l (TPO-Ab). The intra-assay variation coefficients were !5% (FT 3 ), !2% (FT 4 ), and 3.4% (TPO-Ab), and the reference ranges were 4.3-7.4 (FT 3 ), 9.9-17.7 pmol/l (FT 4 ), and !15 mIU/l (TPO-Ab) (19,20).…”

Section: Biochemical Analysesmentioning

confidence: 99%

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Does selenium supplementation affect thyroid function? Results from a randomized, controlled, double-blinded trial in a Danish population

Winther¹,

Bonnema²,

Cold³

et al. 2015

European Journal of Endocrinology

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Objective: Selenium is present in the active site of proteins important for thyroid hormone synthesis and metabolism. The objective of this study is to investigate the effect of selenium supplementation in different doses on thyroid function, under conditions of suboptimal dietary selenium intake. Design: The Danish PREvention of Cancer by Intervention with SElenium pilot study (DK-PRECISE) is a randomized, doubleblinded, placebo-controlled trial. A total of 491 males and females aged 60-74 years were randomized to 100 mg (nZ124), 200 mg (nZ122), or 300 mg (nZ119) selenium-enriched yeast or matching yeast-based placebo tablets (nZ126). A total of 361 participants, equally distributed across treatment groups, completed the 5-year intervention period. Methods: Plasma samples were analyzed for selenium and serum samples for TSH, free triiodothyronine (FT 3 ), and free thyroxine (FT 4 ) at baseline, and after 6 months, and 5 years of supplementation. Results: Plasma selenium concentrations increased significantly and dose-dependently in treatment groups receiving selenium (P!0.001). Serum TSH and FT 4 concentrations decreased significantly and dose-dependently by 0.066 mIU/l (PZ0.010) and 0.11 pmol/l (PZ0.015), respectively, per 100 mg/day increase, with insignificant differences between 6 months and 5 years. No significant effects were found for FT 3 and FT 3 :FT 4 ratio. Conclusions: In euthyroid subjects, selenium supplementation minutely and dose-dependently affects thyroid function, when compared with placebo, by decreasing serum TSH and FT 4 concentrations. Based on these findings, selenium supplementation is not warranted under conditions of marginal selenium deficiency. However, a role for selenium supplementation in the treatment of autoimmune thyroid diseases is still unresolved.

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The role of metabonomics as a tool for augmenting nutritional information in epidemiological studies

et al. 2013

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Most chronic diseases have been demonstrated to have a link to nutrition. Within food and nutritional research there is a major driver to understand the relationship between diet and disease in order to improve health of individuals. However, the lack of accurate dietary intake assessment in free-living populations, makes accurate estimation of how diet is associated with disease risk difficulty. Thus, there is a pressing need to find solutions to the inaccuracy of dietary reporting. Metabolic profiling of urine or plasma can provide an unbiased approach to characterizing dietary intake and various high-throughput analytical platforms have been used in order to implement targeted and nontargeted assays in nutritional clinical trials and nutritional epidemiology studies. This review describes first the challenges presented in interpreting the relationship between diet and health within individual and epidemiological frameworks. Second, we aim to explore how metabonomics can benefit different types of nutritional studies and discuss the critical importance of selecting appropriate analytical techniques in these studies. Third, we propose a strategy capable of providing accurate assessment of food intake within an epidemiological framework in order establish accurate associations between diet and health.

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Genetic and environmental interrelations between measurements of thyroid function in a healthy Danish twin population

Cited by 37 publications

References 20 publications

Heredity and lifestyle in the determination of between-subject variation in thyroid hormone levels in euthyroid men

Heredity and lifestyle in the determination of between-subject variation in thyroid hormone levels in euthyroid men

Does selenium supplementation affect thyroid function? Results from a randomized, controlled, double-blinded trial in a Danish population

The role of metabonomics as a tool for augmenting nutritional information in epidemiological studies

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