Genetic and Hematologic Endpoints in Astyanax altiparanae (Characidae) After Exposure and Recovery to Water-Soluble Fraction of Gasoline (WSFG)

Galvan, Gabrieli Limberger; Lirola, Juliana Roratto; Felisbino, Karoline; Vicari, Taynah; Yamamoto, Carlos Itsuo; Cestari, Marta Margarete

doi:10.1007/s00128-016-1816-5

Cited by 15 publications

(5 citation statements)

References 37 publications

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“…In the present study, it was observed that D. iguape was a good biological model, responding well as a bioindicator, corroborating with other studies that also used lambaris to study lethal and sublethal effects of pesticides (Erbe et al 2010;Bueno-Krawczyk et al 2015;Galvan et al 2016) and effects of other pollutants such as gasoline (Galvan et al 2016) and carbofuran (Barbieri et al 2019).…”

Section: Discussionsupporting

confidence: 90%

Sublethal effects of propiconazole on the metabolism of lambari Deuterodon iguape (Eigenmann 1907), a native species from Brazil

Henriques

Rezende

Castilho‐Barros

et al. 2021

Fish Physiol Biochem

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The objective of this study was to analyze the sublethal effects of propiconazole on Deuterodon iguape a native sh common in Brazil, which has potential for aquaculture and use as a bioindicator. The hypothesis was to test whether D. iguape has a metabolism similar to Danio rerio so that its use in bioassays may be validated. Lethal concentration (LC50) and metabolic rates were studied in sh exposed to propiconazole. There was an increase and decrease in the metabolic rate at 0.01 and 0.1 µg L -1 , with a statistical difference from the control ratio for the two species. The same trend towards ammonia excretion was observed, initially increasing to a concentration of 0.01 µg L -1 and then decreasing as the concentration of propiconazole was increased. The averages of speci c ammonia excretion in all concentrations were signi cantly different compared to the control. It was concluded that exposure to propiconazole increased the metabolic rates of D. Iguape and D. rerio, up to 0.05 µg L -1 , and decreased the rates when the concentration was doubled (0.1 µg L -1 ); causing serious problems in sh metabolism. D. iguape proved to be a good and useful bioindicator for ichthyologists or ecologists in studies of moderate pesticide contamination in freshwater aquatic environments, as its metabolic response was similar to D. rerio.

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Section: Discussionsupporting

confidence: 90%

Sublethal effects of propiconazole on the metabolism of lambari Deuterodon iguape (Eigenmann 1907), a native species from Brazil

Henriques

Rezende

Castilho‐Barros

et al. 2021

Fish Physiol Biochem

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“…They suggested that the activation of interdependent cascades of enzymes (i.e., superoxide dismutase and catalase), involved in attenuating the oxidative stress and repairing damaged DNA, was responsible for this decline in MN frequency. Genotoxic evaluation after recovery assay with other xenobiotics also showed a decline in the frequency of MN [26][27][28], which was explained in part by an increased splenic erythrophagia [26]. Therefore, it is plausible that both phenomena, activation of enzymes involved in cellular repair and an increased erythrophagia may also be accounted for the lack of detectable DNA damage in erythrocytes after exposure to the nonlethal concentration of cATZ and the recovery of this damage induced by sublethal cATZ concentration described herein.…”

Section: Discussionmentioning

confidence: 99%

Effects of sublethal and realistic concentrations of the commercial herbicide atrazine in Pacu (Piaractus mesopotamicus): Long-term exposure and recovery assays

et al. 2020

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Background and Aim: The commercial formulations of the herbicide atrazine (cATZ) are widely employed in Brazilian agriculture, and, as a consequence, ATZ has been found at levels above that established by law in the river basins in Brazil. Although the toxicity of ATZ in fish is well documented, there are few studies on the recovery capacity after cATZ exposure. This work aimed to evaluate, using several biomarkers, the toxic effects of long-term exposure to the sublethal (3.57 mg/L) and nonlethal realistic (3.00 μg/L) cATZ concentrations followed by a recovery assay, in fingerlings of a Brazilian teleost, the Piaractus mesopotamicus (pacu). Materials and Methods: Pacu fingerlings were housed in glass tanks and divided into the following experimental groups (two tanks/group): Exposure control = EC, recovery control = RC, the sublethal groups exposed to 3.57 mg/L of cATZ, (sublethal exposure group = SLE and sublethal recovery group = SLR) and the nonlethal groups treated with 3.00 μg/L of cATZ (nonlethal exposure group = NLE and nonlethal recovery group = NLR). The exposure assay was semi-static with a duration of 30 days and the recovery assay (after cATZ withdrawal) lasted 14 days. Several biomarkers were evaluated in fingerlings from all groups: The swimming behavior, the body weight gain, the micronucleus formation and nuclear alterations in erythrocytes, and the hepatic and renal histopathology analyzed by qualitative and semi-quantitative morphological methods (using light and electron microscopy). Results: No significant difference in weight gain was observed among the groups after the exposure and recovery assays. The sublethal exposure induced impaired swimming movements, significant histopathological alterations, including necrosis in the liver and kidney, and a significant increase in the frequency of micronuclei in erythrocytes. The nonlethal exposure induced only subtle histopathological changes in the liver and kidney. After recovery assay, no genotoxic alteration was noted in pacu exposed to sublethal concentration, while the cATZ-induced kidney damage was partially reversed but not the hepatic injury. Conclusion: cATZ exhibits long-term toxic effects on pacu, even at relatively low concentrations, affecting mainly the liver and the kidney, and the effects of sublethal concentration are only partially reversed after cATZ withdrawal.

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“…Regarding the GWSF effects observed, this fraction also proved to be toxic at relatively lower concentrations (0.05–2.5%) for D. similis than those reported for adult fish Danio rerio and Astyanaxalti paranae (Galvan et al 2016), with LC50 (96h) values of 20 and 15%, respectively. Simonato et al (2013) exposed the fish Prochilodus lineatus for 96 h to GWSF and observed the occurrence of hemolysis, hyperglycemia, and changes in the ionic balance of the gills, resulting in increased chloride‐cell density.…”

Section: Discussionmentioning

confidence: 65%

Fire Suppression Agents Combined with Gasoline in Aquatic Ecosystems: A Mixture Approach

Daniel

Silva

Abessa

et al. 2020

Enviro Toxic and Chemistry

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Fire suppression agents are recommended for extinguishing fires by flammable liquids and frequently end in water bodies, combined with the fuels. There is a lack of toxicity information on these commercial formulations and the effects of mixtures of fire suppression agents and fuels. The aim of the present study was to evaluate the toxic effects of different fire suppression agents, the gasoline water‐soluble fraction (GWSF), and mixtures of each fire suppression agent and GWSF. Individual tests were performed with Daphnia similis and Artemia sp.; the most toxic fire suppression agents to D. similis and Artemia sp. were F‐500®, Cold Fire®, Agefoam®, and Kidde Sintex® 1%; the GWSF was the least toxic. The concentration addition model was used to predict the mixture effects and evaluate synergism/antagonism, dose ratio dependence, and dose level dependence. Cold Fire with GWSF showed dose level deviation to D. similis, marked mainly by synergism; for Artemia sp., the dose ratio pattern was predicted, with a synergistic response mainly by Cold Fire. Agefoam and GWSF behaved additively for D. similis and dose ratio for Artemia sp., with synergism being caused by Agefoam. Kidde Sintex 1% with GWSF were dose ratio for both organisms, with Kidde Sintex 1% being responsible for synergism. Our results show that some mixtures of fire suppression agents and GWSF may cause toxicity to aquatic organisms, posing risk in a real environmental scenario, such as a major fire combat. Environ Toxicol Chem 2021;40:767–779. © 2020 SETAC

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Genetic and Hematologic Endpoints in Astyanax altiparanae (Characidae) After Exposure and Recovery to Water-Soluble Fraction of Gasoline (WSFG)

Cited by 15 publications

References 37 publications

Sublethal effects of propiconazole on the metabolism of lambari Deuterodon iguape (Eigenmann 1907), a native species from Brazil

Sublethal effects of propiconazole on the metabolism of lambari Deuterodon iguape (Eigenmann 1907), a native species from Brazil

Effects of sublethal and realistic concentrations of the commercial herbicide atrazine in Pacu (Piaractus mesopotamicus): Long-term exposure and recovery assays

Fire Suppression Agents Combined with Gasoline in Aquatic Ecosystems: A Mixture Approach

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