Genetic and immunologic relationships between vaccine and field strains for vaccine selection of type A foot-and-mouth disease virus circulating in East Asia

Lee, Seo-Yong; Park, Min-Eun; Kim, Rae-Hyung; Ko, Mi-Kyeong; Lee, Kwang‐Nyeong; Kim, Su-Mi; Shim, Hang-Sub; Kim, Byounghan; Lee, Jong-Soo

doi:10.1016/j.vaccine.2014.12.007

Cited by 5 publications

(5 citation statements)

References 28 publications

(32 reference statements)

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“…However, A/Pocheon/KOR/2010, which occurred in January 2010, differs from the A22 Iraq strain in antigenicity. Phylogenetic, serologic, and sequence analyses indicated that the A/Pocheon/KOR/2010 strain was most closely related to the A Malaysia 97 strain [53]. With reference to this scientific literature, vaccine strains were selected for antigenic epitopes of OVM and AVM.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a Novel Multiepitope Vaccine Candidate against Foot-and-Mouth Disease Virus Serotype O and A

et al. 2022

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Foot-and-mouth disease (FMD) is a highly contagious and economically devastating disease in cloven-hoofed animals. To prevent the spread of FMD virus (FMDV), traditional inactivated vaccines are used to immunize susceptible animals in disease-endemic countries. However, the inactivated FMD vaccine has several limitations, including safety concerns. To overcome these limitations, subunit proteins have been studied as alternative vaccine candidates. In this study, we designed two multiepitope recombinant proteins (OVM and AVM) containing antigenic sites (residue of VP1 132–162 and residue of VP1 192–212) of three topotypes of FMDV serotype O or three topotypes of FMDV serotype A. Each recombinant protein was efficiently expressed in Escherichia coli with high solubility, and the immunogenicity and protective efficacy of the proteins as FMD vaccine candidates were evaluated. The results showed that OVM and AVM emulsified with ISA201 adjuvant induced effective antigen-specific humoral and cell-mediated immune responses and successfully protected mice from O/Jincheon/SKR/2014, O/VET/2013, and A/Malaysia/97 viruses. In addition, intramuscular immunization of pigs with the OVM and AVM emulsified with ISA201 elicited effective levels of neutralizing antibodies to the viruses with homologous epitopes. Importantly, OVM-AVM emulsified with CAvant®SOE-X adjuvant conferred 100% protection against the O/Jincheon/SKR/2014 virus with homologous residues and 75% protection against A/SKR/GP/2018 with heterologous residues. The results presented in this study suggest that the combination of OVM and AVM protein with an effective adjuvant could yield an effective and safe vaccine candidate for the prevention and control of foot-and-mouth disease. In addition, our results provide a vaccine platform that can safely, cost-efficiently, and rapidly generate protective vaccine candidates against diverse FMDVs.

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Section: Discussionmentioning

confidence: 99%

Efficacy of a Novel Multiepitope Vaccine Candidate against Foot-and-Mouth Disease Virus Serotype O and A

et al. 2022

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“…Cells were grown at 37°C under 5% CO 2 in humidified conditions. Viruses like O/Jincheon/SKR/2014 (GenBank KX162590, Mya-98 lineage of the SEA topotype) of FMDV serotype O, which was prevalent in Republic of Korea in 2014; A Malaysia 97 (GenBank KJ933864, Sea-97 lineage of the ASIA topotype) used frequently in Southeast Asia, which is considered to have a medium priority of vaccine recommendation from the World Reference Laboratory for Foot-and-Mouth Disease (WRLFMD, Pirbright, UK) [15]; and Asia1/MOG/05 (GenBank EF614458, geno-group V in the Asia region), which was prevalent in East Asia in 2005-2009, were used. O Jincheon/SKR/2014 was isolated in Jincheon, Chungbuk province in 2014 during the FMD outbreak in Korea.…”

Section: Cells Viruses and Animalsmentioning

confidence: 99%

Application of mouse model for effective evaluation of foot-and-mouth disease vaccine

Lee

et al. 2016

Vaccine

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“…However, there are very limited genomic sequences, even partial, of this lineage in the public database. Recently, prior to this study, complete genomic sequences of this lineage have been reported for only six Vietnamese isolates collected in 2009 ( 4 ) and a South Korean isolate collected in 2010 ( 5 ).…”

Section: Genome Announcementmentioning

confidence: 99%

Complete Genome Sequence of a Foot-and-Mouth Disease Virus of Serotype A Isolated from Vietnam in 2013

et al. 2015

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Genetic and immunologic relationships between vaccine and field strains for vaccine selection of type A foot-and-mouth disease virus circulating in East Asia

Cited by 5 publications

References 28 publications

Efficacy of a Novel Multiepitope Vaccine Candidate against Foot-and-Mouth Disease Virus Serotype O and A

Efficacy of a Novel Multiepitope Vaccine Candidate against Foot-and-Mouth Disease Virus Serotype O and A

Application of mouse model for effective evaluation of foot-and-mouth disease vaccine

Complete Genome Sequence of a Foot-and-Mouth Disease Virus of Serotype A Isolated from Vietnam in 2013

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