Genetic aspects of selective immunoglobulin A deficiency.

Familial Clustering of Selective IgA Deficiency

“…On the other hand, IgA deficiency may be connected with various disease states [ 3 ] and chromosomal defects Many families have been reported in which the IgA deficiency appears to be under genetic control. Based on studies of only one or a few 17,171. families, autosomal dominant 14, 9,19,22, 231, autosomal recessive [ll, 12, 19, 201, and intermediate [25] or polygenic types of inheritance [6,8] have been suggested. The probands have usually been found among hospital patients.…”

Deficiencia de IgA: análisis clínico

“…Creemos tamblen de interes investigar los parientes de nifios afectados por esta deficiencia, ya que se describe una mayor incidencia familiar de esta alteraci6n (1,4). En nuestra serie, esta investigaci6n se efectu6 en 3 casos, siendo positiva en 1 de ellos (MMZ, Tabla N?…”

Immunoglobulins.

“…Autosomal dominant, autosomal recessive, and polygenic phenomena have been postulated to account for familial cases of IgA deficiency. The latter explanation now seems more likely in view of the frequent occurrences of sporadic cases; the complete absence of IgA, low IgA, and normal IgA levels in members of the same family; and the lack of uniform response (Grundbacher, 1972). However, the isolated absence of IgA occurs in a number of normal people, ie, with no demonstrable ill effects from this phenomena.…”