Genetic Association between ERCC5 rs17655 Polymorphism and Colorectal Cancer Risk: Evidence Based on a Meta-analysis

Zeng, Yong; Li, Wei; Wang, Yajie; Liu, Chuan

doi:10.7314/apjcp.2015.16.13.5565

Cited by 11 publications

(11 citation statements)

References 39 publications

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“…We found a certain genotype of rs751402 to increase gastric cancer risk significantly in comparison to the wild-type sequence. Previous studies have investigated associations between ERCC5 gene polymorphisms and risk of various cancers (Luo et al, 2013;Liang et al, 2014;Lu et al, 2014;Na et al, 2015;Zeng et al, 2015). Luo et al (2013) conducted a case-control study to assess the influence of several single nucleotide polymorphisms of DNA repair genes on glioma risk, finding that the ERCC5Asp1558Hisvariation is connected to susceptibility to this cancer.…”

Section: Discussionmentioning

confidence: 99%

“…However, Lu et al (2014) carried out a case-control investigation in a Chinese population, from which they concluded that certain variants of this same polymorphism are associated with increased risk of laryngeal cancer. In a separate Chinese case-control study, Na et al (2015) failed to connect rs751402 with breast cancer risk, while a nine-study meta-analysis conducted by Zeng et al (2015) suggested that the ERCC5 rs17655 polymorphism might contribute to colorectal cancer genetic susceptibility. Two reports have tested the association between ERCC5 gene polymorphisms and gastric cancer development, but with inconclusive results (Hussain et al, 2009;Duan et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported that ERCC5 gene polymorphisms are associated with the development of certain malignancies, including colorectal, breast, lung, laryngeal, and prostate cancers, and glioma (Luo et al, 2013;Liang et al, 2014;Lu et al, 2014;Zhang et al, 2014;Na et al, 2015;Zeng et al, 2015). Few studies have reported the association between ERCC5 gene polymorphisms and gastric cancer risk (Hussain et al, 2009;Duan et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Association between ERCC5 gene polymorphisms and gastric cancer risk

et al. 2016

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ABSTRACT. We investigate the role of ERCC5 gene polymorphisms (rs17655 and rs751402) in the development of gastric cancer in a Chinese population. A total of 142 gastric cancer patients whose diagnoses were confirmed by pathology, and 274 control subjects were recruited from Tangshan Gongren Hospital between March 2013 and March 2015. Genotyping of ERCC5 rs17655 and rs751402 polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism. Compared with the control subjects, we found that gastric cancer patients were more likely to be older, smoke tobacco, drink alcohol, and suffer from Helicobacter pylori infection. Using a chi-square test, a significant difference was observed in the distribution ofERCC5 rs751402 genotypes between patient and control groups (chi-square = 7.79, P = 0.02). In addition, unconditional multiple logistic regression analysis revealed that the AA genotype of rs751402 significantly increased gastric cancer risk compared to the GG genotype [odds ratio (OR) = 2.61, 95%CI = 1.23-5.49; P = 0.005]. Moreover, we found that the AA genotype correlated with elevated risk of gastric cancer when compared to the GG+AG genotype under a recessive model (OR = 2.21, 95%CI = 1.11-4.39; P = 0.01). In conclusion, we suggest that the ERCC5 rs751402 polymorphism is associated with development of gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between ERCC5 gene polymorphisms and gastric cancer risk

et al. 2016

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“…Previous studies have reported that the ERCC5 rs17655 polymorphism has important roles in the development of several kinds of cancer, such as colorectal cancer, uterine cervical cancer, lung cancer, laryngeal cancer, as well as breast cancer (Li et al, 2014;Liang et al, 2014;Joo et al, 2015;Na et al, 2015;Zeng et al, 2015). Li et al (2014) reported that the ERCC5 rs17655 polymorphism is correlated with susceptibility to laryngeal cancer, while Joo et al (2015) conducted a study in a Korean population, and found that it was associated with the development of cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Li et al (2014) reported that the ERCC5 rs17655 polymorphism is correlated with susceptibility to laryngeal cancer, while Joo et al (2015) conducted a study in a Korean population, and found that it was associated with the development of cervical cancer. Zeng et al (2015) conducted a meta-analysis of 9 studies, and found that this polymorphism might influence the development of colorectal cancer. In contrast, a previous metaanalysis of 44 published case-control studies reported that the ERCC5 rs17655 polymorphism did not influence cancer risk (Zhu et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population

Liu

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We conducted a hospital-based case-control study to investigate the association between 3 common SNPs in the ERCC5 gene (rs1047768, rs751402, and rs17655) and the risk of developing gastric cancer. Between January 2013 and December 2014, samples were collected from 216 gastric cancer patients and 216 control subjects. ERCC5 rs1047768, rs751402, and rs17655 polymorphisms were genotyped by polymerase chain reaction combined with restriction fragment length polymorphism analysis. By conditional logistic regression analysis, the GG genotype of rs17655 was found to be associated with an elevated risk of gastric cancer in a codominant model, and the adjusted OR (95%CI) was 1.96 (1.10-3.50). Moreover, in a dominant model, the CG + GG genotype of rs17655 was correlated with an increased risk of gastric cancer compared to the CC genotype (OR = 1.48; 95%CI = 1.00-2.22). rs1047768 and rs751402 were not significantly correlated with an increased or decreased gastric cancer risk.

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Association between nucleotide excision repair gene polymorphism and colorectal cancer risk

Zhang

Zhou

et al. 2019

Clinical Laboratory Analysis

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Background The nucleotide excision repair system removes a wide variety of DNA lesions from the human genome, and plays an important role in maintaining genomic stability. Single nucleotide polymorphisms (SNPs) in nucleotide excision repair are associated with the various forms of tumor susceptibility. However, the relationship between NER polymorphism and colorectal cancer is not clear. Methods In this study, three candidate SNPs including ERCC4 (rs6498486), ERCC1 (rs3212986), and ERCC5 (rs17655) were analyzed in 1101colorectal cancer patients and 1175 healthy control patients from Jiangsu province (China). Then, we performed Immunohistochemistry, qPCR, and luciferase assay to determine the potential mechanisms. Results The ERCC4 rs6498486 AC/CC genotypes show lower susceptibility to CRC than those carrying rs6498486 AA (Adjusted OR = 0.82, 95% CI = 0.69‐0.97). However, we did not observe any association between the colorectal cancer risk and the rs3212986(ERCC1) and rs17655(ERCC5) polymorphisms. Immunohistochemistry, qPCR, and luciferase assay revealed that rs6498486 A > C polymorphism in the ERCC4 promoter region could lessen the expression level of ERCC4 by impacting the binding ability of the transcription factor NF‐kB, thereby affecting the transcription activity of the ERCC4 gene and decreased ERCC4 gene expression. Conclusion In brief, our finding demonstrated that ERCC4 rs6498486 serves as a potential biomarker of CRC susceptibility for the development of colorectal cancer.

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Genetic Association between ERCC5 rs17655 Polymorphism and Colorectal Cancer Risk: Evidence Based on a Meta-analysis

Cited by 11 publications

References 39 publications

Association between ERCC5 gene polymorphisms and gastric cancer risk

Association between ERCC5 gene polymorphisms and gastric cancer risk

Association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population

Association between nucleotide excision repair gene polymorphism and colorectal cancer risk

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