Genetic association between FXIII and β-fibrinogen genes and women with recurrent spontaneous abortion: a meta- analysis

Li, Jie; Wu, Hongbo; Chen, Yang; Wu, Hui-Mei; Xu, Hong; Li, Liuming

doi:10.1007/s10815-015-0471-9

Cited by 14 publications

(8 citation statements)

References 33 publications

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“…Overall, most studies failed to find the meaningful association of different genetic models of β-fibrinogen 455G/A (rs1800790) polymorphism with RPL, especially in the Asian and Caucasian subgroups. [ 35 36 37 ] This could be attributed to gene-gene interaction, gene-environment interaction, or other β-fibrinogen polymorphisms that may mask β-fibrinogen gene function. These results were in contrary to other studies.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of specific gene polymorphisms related to thrombophilia in Egyptian women with recurrent pregnancy loss

Issa¹,

Elneily²,

El-Tawab

et al. 2021

J Hum Reprod Sci

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Background: Despite the enhanced progress in identifying a number of leading causes to fetal miscarriage, still some women suffer from recurrent pregnancy loss (RPL) for unknown cause. A hidden genetic influence of coexisting hereditary thrombophilia was assumed to have a role. Aim: The aim was to investigate the association between unexplained RPL and thrombophilic gene variants of angiotensin I-converting enzyme ( ACE ) (rs4646994) and β-fibrinogen (rs1800790) genes. Settings and Design: The present case–control study was conducted on unexplained RPL in eighty women and eighty matched controls with no history of previous pregnancy loss. Materials and Methods: Analysis of extracted DNA was performed using polymerase chain reaction-restriction fragment length polymorphism method. Statistical Analysis: The frequency of genotypes and alleles was compared between groups using Chi-square test or Fisher's exact test. Risk assessment was made by odds ratio (OR) at a 95% confidence interval (CI). Results: Women with RPL group had higher frequency of DD than controls (47.5%, 31.25%, respectively, P = 0.086). D allele frequency was 0.67 and 0.54 in the control ( P = 0.022). D allele carriers were at higher risk of RPL than the control as OR was 1.694 at 95% CI from 1.08 to 2.67. There was no association between the rs1800790 variant of β-fibrinogen gene and RPL. Conclusion: Females who are carriers for D allele of ACE I/D gene polymorphism are more liable to suffer from RPL. Screening for hereditary thrombophilia in females who are planning to conceive and have a history of RPL of unidentified cause is of great value to provide proper management and genetic counseling to high-risk couples.

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Section: Discussionmentioning

confidence: 99%

The prevalence of specific gene polymorphisms related to thrombophilia in Egyptian women with recurrent pregnancy loss

Issa¹,

Elneily²,

El-Tawab

et al. 2021

J Hum Reprod Sci

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“…In addition, no ethnicity and age matching were considered between two case and control groups in the former study. Li et al in a meta-analysis of 12 assays which had been performed on the association of β-fibrinogen-455G/A polymorphism and risk of RPL among Asian and Caucasian populations, no significant difference was found between case and control groups [23]. Al-Astal et al could not find any association between FGB -455G/A polymorphism and RPL risk among Palestinian women—they calculated the frequency of A and G alleles as 17.6% and 82.4% among RPL patients, which is close to our results and could be a further support of our findings [24].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, FGB -455G/A polymorphism may have a role in increasing serum fibrinogen level and subsequent coagulation and thrombosis formation in the pathogenesis of RPL [28]. Although the association of FGB -455G/A polymorphism with RPL has been found to be meaningless in most of the studies, a combination of it with other thrombophilic variants was shown to be significant [23]. In addition, -455G/A polymorphism has been demonstrated as a significant gene variant associated with ischemic strokes in various studies [29].…”

Section: Discussionmentioning

confidence: 99%

Investigating Association of rs5918 Human Platelets Antigen 1 and rs1800790 Fibrinogen β Chain as Critical Players with Recurrent Pregnancy Loss

2018

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Thrombophilia gene variants have been shown to be associated with higher risk of recurrent pregnancy loss (RPL). Due to the role of human platelets antigen 1 (HPA-1) and fibrinogen β chain (FGB) as critical players in the coagulation process, their most important variants including rs5918 T > C and rs1800790 G > A were selected to be studied in women affected by RPL. Three milliliters of peripheral blood were drawn from 110 women with history of at least two consecutive spontaneous abortion and 110 healthy women controls. rs5918 T > C and rs1800790 G > A of HPA-1 and FGB genes, respectively, were selected to be analyzed through polymerase chain reaction-restriction fragment length polymorphism (PCR_RFLP) following DNA isolation using QIAamp DNA Blood Mini Kit. Heterozygote genotype (TC) of HPA-1 gene rs5918 polymorphism was significantly associated with risk of RPL (p-value = 0.02). Although, rs1800790 G > A of FGB gene was not associated with RPL, its combination with rs5918 polymorphism was associated with increased risk of RPL. Owing to the critical roles of FGB and HPA-1 genes in coagulation, and thrombosis and several confinements on the meaningful association between the combination of those polymorphism with risk of RPL, including them in the thrombophilia panel may increase detection rate of hereditary thrombophilia patients. However, further studies with larger sample sizes are required to shed light on the exact role of the studied gene polymorphism, especially rs1800790 G > A of FGB gene variant in pathogenesis of RPL.

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“…Factor II prothrombin (PTm) G20210A mutation plays an important role in RPL [17]. Coagulation factor XIII and β fibrinogen are both important for the coagulation of blood and a meta-analysis that was performed revealed that only FXIII Val34Leu polymorphism had an association with RPL [26].…”

Section: Thrombophilic Factorsmentioning

confidence: 99%

Genetic Factors Associated With Recurrent Pregnancy Loss

Kar¹,

B²

2017

OGIJ

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The aetiology behind recurrent pregnancy loss is unknown in about 50% of cases despite having a lot of known factors. Two to five percent of RPL occur due to a genetic cause. A structural or a numerical abnormality in the chromosomes of the parents or in the foetus can result in pregnancy loss. Several genes like those that are involved in angiogenesis, oxidative stress, clotting and inflammation have also been associated with RPL. Recent advances such as the use of microarrays and next generation sequencing for detecting the genetic abnormalities in RPL patients, in the aborted foetuses and in the embryos in the form of preimplantation genetic screening can help to better diagnose and treat RPL patients.

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Genetic association between FXIII and β-fibrinogen genes and women with recurrent spontaneous abortion: a meta- analysis

Cited by 14 publications

References 33 publications

The prevalence of specific gene polymorphisms related to thrombophilia in Egyptian women with recurrent pregnancy loss

The prevalence of specific gene polymorphisms related to thrombophilia in Egyptian women with recurrent pregnancy loss

Investigating Association of rs5918 Human Platelets Antigen 1 and rs1800790 Fibrinogen β Chain as Critical Players with Recurrent Pregnancy Loss

Genetic Factors Associated With Recurrent Pregnancy Loss

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