2022
DOI: 10.1590/0103-6440202205113
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Genetic, Cellular and Molecular Aspects involved in Apical Periodontitis

Abstract: The development, establishment and repair of apical periodontitis (AP) is dependent of several factors, which include host susceptibility, microbial infection, immune response, quality of root canal treatment and organism's ability to repair. The understanding of genetic contributions to the risk of developing AP and presenting persistent AP has been extensively explored in modern Endodontics. Thus, this article aims to provide a review of the literature regarding the biochemical mediators involved in immune r… Show more

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Cited by 16 publications
(12 citation statements)
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“…AP is a complex pathology involving multiple factors, and various inflammatory and anti-inflammatory molecules may influence the state and progression of the disease [1]. The role of SNPs in the patient's response to root canal treatment, reflects the involvement of the heredity in the individual success of endodontic treatment [5], acting as a risk or a protective factor for the development and progression of AP [6].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…AP is a complex pathology involving multiple factors, and various inflammatory and anti-inflammatory molecules may influence the state and progression of the disease [1]. The role of SNPs in the patient's response to root canal treatment, reflects the involvement of the heredity in the individual success of endodontic treatment [5], acting as a risk or a protective factor for the development and progression of AP [6].…”
Section: Discussionmentioning
confidence: 99%
“…The interactions between various inflammatory and anti‐inflammatory molecules can influence the disease state and progression [1]. The host susceptibility, microbial infection, immune response, quality of the endodontic treatment and organism's ability to repair are factors that may interfere with the development, establishment and repair of AP [5]. Although the presence of bacteria is the determining factor of PAP, heredity may be a significant contributor [6].…”
Section: Introductionmentioning
confidence: 99%
“…The pathological mechanism of CAP is still unclear. Microbial antigens from infected root canals can stimulate speci c in ammatory and nonspeci c immune responses in periapical tissues [6][7][8][9][10]. Gram negative bacteria is the main dominant bacterium in infected root canals and periapical tissue lesions.…”
Section: Introductionmentioning
confidence: 99%
“…In the course of the ongoing endodontic infection, microbes, their antigens and toxins reach the apical periodontal ligament and surrounding tissues through the apical foramen and trigger immunological defence mechanisms (Georgiou et al, 2019; Martinho et al, 2014). A delicate balance between protective and destructive reactions ultimately results in the formation of granulation tissue around the apical foramen, consisting of necrotic, exudative, granulomatous and fibrous zones (Márton & Kiss, 2000, 2014; Morse, 1977; Petean et al, 2022; Yanagisawa, 1980). In the necrotic and exudative zones, abundant neutrophils eliminate the majority of microbes rendering the granulomatous and fibrous zones sterile (Márton & Kiss, 2014).…”
Section: Introductionmentioning
confidence: 99%