Genetic context modulates aging and degeneration in the murine retina
Olivia J. Marola,
Michael MacLean,
Travis L. Cossette
et al.
Abstract:Background: Age is the principal risk factor for neurodegeneration in both the retina and brain. The retina and brain share many biological properties; thus, insights into retinal aging and degeneration may shed light onto similar processes in the brain. Genetic makeup strongly influences susceptibility to age-related retinal disease. However, studies investigating retinal aging have not sufficiently accounted for genetic diversity. Therefore, examining molecular aging in the retina across different genetic ba… Show more
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