Genetic determinants and postorthodontic external apical root resorption in Czech children

Linhartová, Petra Bořilová; Černochová, Pavlína; Kaštovský, Jakub; Vranková, Zuzana; Sirotková, Martina; Hollá, Lýdie Izakovičová

doi:10.1111/odi.12564

Cited by 26 publications

(25 citation statements)

References 40 publications

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“…Various research groups studied the single nucleotide polymorphisms (SNPs) in the OPN coding gene Spp1 and its effect on the tooth root resorption [ 58 – 60 ]. Iglesias-Linares and coworkers first reported that OPN gene SNPs (rs9138, rs11730582) are involved in the susceptibility of external root resorption in patients undergoing orthodontic treatment [ 58 ].…”

Section: Opn-mediated Tooth Root Resorption and Repairmentioning

confidence: 99%

“…Iglesias-Linares and coworkers first reported that OPN gene SNPs (rs9138, rs11730582) are involved in the susceptibility of external root resorption in patients undergoing orthodontic treatment [ 58 ]. However, in another study, OPN gene SNPs and its effect on external apical root resorption (EARR) were not confirmed in Czech children [ 60 ]. However, the association between individual variability in purinoreceptor (P2X7) and EARR was suggested to be an important factor in the etiopathogenesis of EARR [ 60 ].…”

Section: Opn-mediated Tooth Root Resorption and Repairmentioning

confidence: 99%

“…However, in another study, OPN gene SNPs and its effect on external apical root resorption (EARR) were not confirmed in Czech children [ 60 ]. However, the association between individual variability in purinoreceptor (P2X7) and EARR was suggested to be an important factor in the etiopathogenesis of EARR [ 60 ]. Iglesias-Linares et al later implicated the Spp1 gene SNPs to assess the orthodontically induced external apical root resorption (OIEARR) in patients with removable appliances versus fixed appliances [ 59 ].…”

Section: Opn-mediated Tooth Root Resorption and Repairmentioning

confidence: 99%

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Role of osteopontin in bone remodeling and orthodontic tooth movement: a review

et al. 2018

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In this review, most of the known and postulated mechanisms of osteopontin (OPN) and its role in bone remodeling and orthodontic tooth movement are discussed based on available literature. OPN, a multifunctional protein, is considered crucial for bone remodeling, biomineralization, and periodontal remodeling during mechanical tension and stress (orthodontic tooth movement). It contributes to bone remodeling by promoting osteoclastogenesis and osteoclast activity through CD44- and αvβ3-mediated cell signaling. Further, it has a definitive role in bone remodeling by the formation of podosomes, osteoclast survival, and osteoclast motility. OPN has been shown to have a regulatory effect on hydroxyapatite crystal (HAP) growth and potently inhibits the mineralization of osteoblast cultures in a phosphate-dependent manner. Bone remodeling is vital for orthodontic tooth movement. Significant compressive and tensional forces on the periodontium induce the signaling pathways mediated by various osteogenic genes including OPN, bone sialoprotein, Osterix, and osteocalcin. The signaling pathways involved in the regulation of OPN and its effect on the periodontal tissues during orthodontic tooth movement are further discussed in this review. A limited number of studies have suggested the use of OPN as a biomarker to assess orthodontic treatment. Furthermore, the association of single nucleotide polymorphisms (SNPs) in OPN coding gene Spp1 with orthodontically induced root resorption remains largely unexplored. Accordingly, future research directions for OPN are outlined in this review.

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Section: Opn-mediated Tooth Root Resorption and Repairmentioning

confidence: 99%

Section: Opn-mediated Tooth Root Resorption and Repairmentioning

confidence: 99%

Section: Opn-mediated Tooth Root Resorption and Repairmentioning

confidence: 99%

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Role of osteopontin in bone remodeling and orthodontic tooth movement: a review

et al. 2018

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“…We also consider imperative to recognize the epigenetic modulation on coding and noncoding chromosomal regions that influence our proteome, resulting on a dynamic molecular effect rather than a static picture of our protein map. Thus, genotyping our patients represent only one piece of this complex puzzle [40][41][42][43][44][45] . Nonetheless, this type of particular responses associated with the speed of tooth movement, being mediated dynamic genetic characteristics, could generate different functional phenotypes in the population.…”

Section: Discussionmentioning

confidence: 99%

Relationship between the polymorphism in the interleukin 1-β and the treatment time of patients subjected to a modified piezocision technique

et al. 2020

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Aim: We aimed to evaluate the correlation between the polymorphism of the interleukin 1-Beta (IL1-β, +3954 C>T) and tooth movement, in a group of Colombian patients undergoing surgically accelerated orthodontic tooth movement. Methods: The study was nested to a controlled clinical trial. Blood samples were taken from 11 women and 29 healthy Colombian male volunteers between 18 and 40 years old, after 1 year of starting orthodontic treatment. The patients presented malocclusion class I, with grade II or III. To detect the genetic polymorphism of the nucleotide +3954 C to T in the IL-1β gene, we used a real-time PCR assay. Results: Eleven individuals presented the allele 2 (T) heterozygous with the allele 1 (T/C) and 19 individuals were homozygous for the allele 1 (C/C). When analyzing the presence of the SNP, no significant differences were found in any of the variables. The best treatment was reflected in Group 3 (selective upper and lower alveolar decortication and 3D collagen matrix) and Group 4 (only selective alveolar decortication in the upper arch, with 3D collagen matrix), with 27% and 35% more speed respectively than in the control group. Conclusions: Our analyses indicated that a reduction in the total treatment time can be mostly potentiated by using decortication and collagen matrices and not for the presence of the allele 2 in the IL-1β. Nevertheless, it is important that further studies investigate if the polymorphism could be associated with the speed of tooth movement and analyze the baseline protein levels.

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“…EARR is a common phenomenon after orthodontic treatment. 23 30 31 Therefore, assessing the risk of developing EARR after orthodontic treatment is an important factor for successful treatment. Progression of EARR is a multifactorial event.…”

Section: Discussionmentioning

confidence: 99%

Association between genetic polymorphisms and external apical root resorption: A systematic review and meta-analysis

et al. 2018

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ObjectiveTo date, only a few studies have investigated the relationships between genetic polymorphisms and external apical root resorption (EARR). Hence, the aim of this systematic review was to explore the relationship between different gene polymorphisms and their association with EARR.MethodsA complete literature search was conducted by two independent reviewers. The PubMed, Science Direct, and Scopus databases were searched. In addition, the bibliographies of all textbooks and relevant articles were searched manually. A meta-analysis was performed using data entered into the electronic databases until February 28, 2017.ResultsOn the basis of the search, we identified 17 and 7 publications for the systematic review and meta-analysis, respectively. Odds ratio (OR) was used to evaluate the association of the interleukin 1B (+3954) polymorphism and the risk of EARR. The overall OR from the studies was used to estimate the risk of EARR. However, no association was found and no publication bias was apparent for the risk of EARR in patients receiving orthodontic treatment.ConclusionsMore research on the relationship between gene polymorphism and EARR is necessary to determine better specificity of possible interactions.

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Genetic determinants and postorthodontic external apical root resorption in Czech children

Cited by 26 publications

References 40 publications

Role of osteopontin in bone remodeling and orthodontic tooth movement: a review

Role of osteopontin in bone remodeling and orthodontic tooth movement: a review

Relationship between the polymorphism in the interleukin 1-β and the treatment time of patients subjected to a modified piezocision technique

Association between genetic polymorphisms and external apical root resorption: A systematic review and meta-analysis

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