2014
DOI: 10.1371/journal.pone.0089957
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Genetic Determinants of Chronic Obstructive Pulmonary Disease in South Indian Male Smokers

Abstract: The development of chronic obstructive pulmonary disease, upon exposure to tobacco smoke, is the cumulative effect of defects in several genes. With the aim of understanding the genetic structure that is characteristic of our patient population, we selected forty two single nucleotide polymorphisms of twenty genes based on previous studies and genotyped a total of 382 samples, which included 236 patients and 146 controls using Sequenom MassARRAY system. Allele frequencies of rs2276109 (MMP12) and rs1800925 (IL… Show more

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Cited by 17 publications
(21 citation statements)
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“…Likewise, data from studies by Haq et al . and Arja et al . showed an association between the (–82) A/357 A haplotype and the risk of developing COPD.…”
Section: Discussionmentioning
confidence: 79%
See 1 more Smart Citation
“…Likewise, data from studies by Haq et al . and Arja et al . showed an association between the (–82) A/357 A haplotype and the risk of developing COPD.…”
Section: Discussionmentioning
confidence: 79%
“…The results of the present study also disagree with those of Korytina et al31 who found a significant association between the (-82) A/G variant and increased risk of chronic bronchitis. Likewise, data from studies by Haq et al32 and Arja et al33 showed an association between the (-82) A/357 A haplotype and the risk of developing COPD. Regarding the distribution of the MMP-12 Asn357Ser SNP, no significant differences were found among Tunisian COPD patients and healthy controls.…”
mentioning
confidence: 85%
“…rs7671167 was shown to be associated with COPD in former smokers in a Chinese population9 and with COPD and lung function parameters in a population of Southern India39. The G allele of rs7671167 was shown to decrease the risk of COPD and lung cancer3.…”
Section: Discussionmentioning
confidence: 99%
“…NM_006216) contains nine exons, and encodes a 44-kDa cellular and extracellular matrix-associated serine protease inhibitor that is primarily involved in coagulation and fibrinolysis by inhibiting the activity of thrombin, urokinase, and plasmin (Baker et al, 1980;Scott et al, 1985). The expression of SERPINE2 is induced by interleukin-1β, tumor necrosis factor-α, and transforming growth factor-β, which have been shown to be involved in the development of COPD (Vaughan and Cunningham, 1993;Mbebi et al, 1999;Arja et al, 2014). While the role of SERPINE2 in COPD and emphysema has not yet been fully investigated, characterization of SERPINE2 polymorphisms through population-based studies may allow us to answer whether the product of SERPINE2 plays a major role in the pathogenesis of COPD.…”
Section: Discussionmentioning
confidence: 99%