Genetic differentiation and habitat partition of Robertsonian house mouse populations (<i>Mus musculus domesticus</i>) of Tunisia

Saïd, Khaled; Britton‐Davidian, Janice

doi:10.1046/j.1420-9101.1991.4030409.x

Cited by 37 publications

(59 citation statements)

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“…Allele Mod1 c has also been found at low frequency in two other villages-Sommacologna and Grosottoboth characterized by individuals homozygous or heterozygous for the Poschiavo race karyotype (table 1), which is, of course, the only karyotype found in Migiondo. Said & Britton-Davidian 1991). This allele is almost certainly the same as the Mod1 c allele reported in the present study and by Selander et al (1969).…”

Section: Resultssupporting

confidence: 88%

Genetic distinctiveness of a village population of house mice: relevance to speciation and chromosomal evolution

Fraguedakis-Tsolis

Hauffe²,

Searle

1997

Proc. R. Soc. Lond. B

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SUMMARYA population of house mice, Mus musculus domesticus, from the village of Migiondo was found to be genetically distinct from nearby populations in Upper Valtellina (Italian Alps). At the supernatant malic enzyme locus, Mod1, the only alleles found in Migiondo (c and n2) were virtually absent from the other populations in the valley, which were characterized by allele a. The extraordinary genetic distinctiveness of the Migiondo population is apparently the result of genetic drift, perhaps coupled with a founder event, and attests to the existence of nearly impenetrable geographic barriers around the village isolating it from other settlements only a few hundred metres away. The Mod1 features of the house mice in Migiondo are reminiscent of the characteristics of house mice on maritime islands. The genetic confirmation of the geographic isolation of Migiondo is of interest because there is evidence that this village may have been the site of recent speciation and extinction events. The data are also of significance given the phenomenal chromosomal variation in house mice from the vicinity of the Alps. It has frequently been proposed that genetic drift\founder events are of importance in the fixation of chromosomal rearrangements ; this study provides the first direct evidence for their occurrence in alpine mouse populations.

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Section: Resultssupporting

confidence: 88%

Genetic distinctiveness of a village population of house mice: relevance to speciation and chromosomal evolution

Fraguedakis-Tsolis

Hauffe²,

Searle

1997

Proc. R. Soc. Lond. B

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“…Such a level of genetic isolation has only been observed between the POS and UV races in Valtellina (northern Italy) (Capanna and Corti, 1982) and in some contact Heredity areas in the hybrid zone between the Monastir race and the standard race in Tunisia (Said and Britton-Davidian, 1991;Chatti et al, 1999). However, no detailed molecular studies are available for these zones.…”

Section: Discussionmentioning

confidence: 99%

Contact zones between chromosomal races of Mus musculus domesticus. 3. Molecular and chromosomal evidence of restricted gene flow between the CD race (2n = 22) and the ACR race (2n = 24)

2002

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Contact zones between chromosomal races of Mus musculus domesticus. 3. Molecular and chromosomal evidence of restricted gene flow between the CD race (2n = 22) and the ACR race (2n = 24) R Castiglia, F Annesi and E Capanna Dipartimento di Biologia Animale e dell' Uomo, Università di Roma "La Sapienza"-Via A. Borelli 50, 00161 Roma, ItalyThe contact zone between the Ancarano (ACR; 2n = 24) and Cittaducale (CD; 2n = 22) races of Mus musculus domesticus was studied. We used chromosomes and mitochondrial DNA (mtDNA) sequences of the control region as genetic markers to detect introgression between races. In total, 76 mice were trapped at 17 localities. Cytogenetic analysis was performed on 73 mice. A segment of the control region (468 bp) was sequenced in 41 specimens. The two races are distributed parapatrically and the contact zone was identified inside a village (Pizzoli). No mixed population was found in the study area. The contact zone does not correspond to any geographical or ecological barrier but is located

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“…In Monastir (Tunisia) the Rb populations of house mice are fixed for nine pairs of Rb fusions (2n = 22), the combination of which is not known to occur elsewhere (Said et al, 1986(Said et al, , 1991.…”

Section: Introductionmentioning

confidence: 99%

Fertility estimates in the Tunisian all-acrocentric and Robertsonian populations of the house mouse and their chromosomal hybrids

Saïd

Saâd²,

Auffray

et al. 1993

Heredity

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The reproductive features of wild all-acrocentric and 2n 22Robertsonian (Rb) house mice (M. m. domesticus) from Tunisia were studied. The aim was to examine the possibility of a reproductive selective advantage associated with chromosomal change as well as to measure the effect of heterozygosity for a large number of Rb fusions on the fertility of hybrids. Results showed that litter sizes were significantly smaller in Rb than in all-acrocentric mice. This difference, which may represent a favourable demographic strategy related to the habitat segregation observed in the Tunisian mice, needs to be studied further. The F1 hybrids between the two chromosomal races showed a significantly reduced reproductive success and litter size (respectively, 53 per cent and 60 per cent less than either parental race). Analysis of the testicular histology of F1 and backcross males showed in some cases a breakdown of spermatogenesis. The degree of this disturbance was not related to the level of chromosomal heterozygosity suggesting that genetic incompatibilities between the two genomes might be involved. The strong reduction in fertility measured in these hybrids represents a reproductive isolating mechanism effectively reducing gene flow between the all-acrocentric and 22Rb mice populations of Tunisia.

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Genetic differentiation and habitat partition of Robertsonian house mouse populations (Mus musculus domesticus) of Tunisia

Abstract: The karyological analysis of Tunisian populations of house mice revealed the existence of a Robertsonian (Rb) chromosomal race carrying nine pairs of metacentric chromosomes in central Tunisia.

Cited by 37 publications

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Genetic distinctiveness of a village population of house mice: relevance to speciation and chromosomal evolution

Genetic distinctiveness of a village population of house mice: relevance to speciation and chromosomal evolution

Contact zones between chromosomal races of Mus musculus domesticus. 3. Molecular and chromosomal evidence of restricted gene flow between the CD race (2n = 22) and the ACR race (2n = 24)

Fertility estimates in the Tunisian all-acrocentric and Robertsonian populations of the house mouse and their chromosomal hybrids

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