Genetic diversity, cholesterol reduction, and presence of conserved bile salt hydrolase gene in probiotic strains from human milk

Javed, Saman; Munir, Aneela; Javed, Ghulam Ayesha; Latif, Zakia; Javed, Sundus; Arshad, Najma

doi:10.1093/lambio/ovad024

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…Doubling mobilization would be challenging and require a substantial nursing effort with associated costs . Assuming a causal relationship, the effort would seem justified.…”

Section: Discussionmentioning

confidence: 99%

Association Between Mobilization and Composite Postoperative Complications Following Major Elective Surgery

et al. 2023

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ImportanceMobilization after surgery is a key component of Enhanced Recovery after Surgery (ERAS) pathways.ObjectiveTo evaluate the association between mobilization and a collapsed composite of postoperative complications in patients recovering from major elective surgery as well as hospital length of stay, cumulative pain scores, and 30-day readmission rates.Design, Setting, and ParticipantsThis retrospective observational study conducted at a single quaternary US referral center included patients who had elective surgery between February 2017 and October 2020. Mobilization was assessed over the first 48 postoperative hours with wearable accelerometers, and outcomes were assessed throughout hospitalization. Patients who had elective surgery lasting at least 2 hours followed by at least 48 hours of hospitalization were included. A minimum of 12 hours of continuous accelerometer monitoring was required without missing confounding variables or key data. Among 16 203 potential participants, 8653 who met inclusion criteria were included in the final analysis. Data were analyzed from February 2017 to October 2020.ExposuresAmount of mobilization per hour for 48 postoperative hours.OutcomesThe primary outcome was a composite of myocardial injury, ileus, stroke, venous thromboembolism, pulmonary complications, and all-cause in-hospital mortality. Secondary outcomes included hospital length of stay, cumulative pain scores, and 30-day readmission.ResultsOf 8653 included patients (mean [SD] age, 57.6 [16.0] years; 4535 [52.4%] female), 633 (7.3%) experienced the primary outcome. Mobilization time was a median (IQR) of 3.9 (1.7-7.8) minutes per monitored hour overall, 3.2 (0.9-7.4) in patients who experienced the primary outcome, and 4.1 (1.8-7.9) in those who did not. There was a significant association between postoperative mobilization and the composite outcome (hazard ratio [HR], 0.75; 95% CI, 0.67-0.84; P &lt; .001) for each 4-minute increase in mobilization. Mobilization was associated with an estimated median reduction in the duration of hospitalization by 0.12 days (95% CI, 0.09-0.15; P &lt; .001) for each 4-minute increase in mobilization. The were no associations between mobilization and pain score or 30-day readmission.Conclusions and RelevanceIn this study, mobilization measured by wearable accelerometers was associated with fewer postoperative complications and shorter hospital length of stay.

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“…Doubling mobilization would be challenging and require a substantial nursing effort with associated costs . Assuming a causal relationship, the effort would seem justified.…”

Section: Discussionmentioning

confidence: 99%

Association Between Mobilization and Composite Postoperative Complications Following Major Elective Surgery

et al. 2023

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Probiotic effects of human milk‐derived Lactiplantibacillus plantarum M660 on mice with antibiotic‐associated diarrhoea and constipation

Li,

Yan,

et al. 2024

Int J of Dairy Tech

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Lactiplantibacillus plantarum M660 (M660) was isolated from the human milk of a healthy mother. M660 could survive the simulated gastrointestinal conditions without haemolytic and biogenic amine‐producing ability. The faecal water content was reduced, and the recoveries of the cecum and intestinal barrier were accelerated by M660 in the antibiotic‐associated diarrhoea model. In the constipation model, M660 enhanced intestinal motility, improved serum neurotransmitter levels, and reduced colonic injury. Analysis of gut microbiota showed that M660 increased the abundance of potentially beneficial bacteria and decreased the number of potentially pathogenic bacteria. Overall, M660 could be a probiotic candidate to promote infant health.

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Unleashing the Potential of Gut Microbiota: Cholesterol Reduction Through Microbial Bile Acid Metabolism

Nafsi,

Rahman,

Shishir

et al. 2024

CBIOT

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Cholesterol metabolism is a crucial mechanism for preserving cellular functionality, and overall human health. Cardiovascular diseases and other conditions can arise due to dysregulation of cholesterol levels. Bile acids’ enterohepatic circulation greatly influences cholesterol homeostasis. Recent research has emphasized the essential role of the gut microbiota in bile acid metabolism and its association with cholesterol regulation. Living microbial supplements known as probiotics have been studied as a potential means of reducing cholesterol by modifying the gut microbiome. This review explores existing theories of how probiotic production and modification of bile acids affect cholesterol metabolism. Discussion ensues regarding the processes by which probiotics lower cholesterol, including bile acid deconjugation, conversion of cholesterol to coprostanol and cholestenone, co-precipitation of cholesterol with deconjugated bile, and disruption of cholesterol micelles by Bile Salt Hydrolase (BSH). According to research, there are significant therapeutic ramifications in understanding the complex interactions between the gut microbiome and host cholesterol metabolism. More study is required to comprehend the causal mechanisms further and produce new methods for lowering microbiota-mediated cholesterol to enhance human health.

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Genetic diversity, cholesterol reduction, and presence of conserved bile salt hydrolase gene in probiotic strains from human milk

Cited by 4 publications

References 27 publications

Association Between Mobilization and Composite Postoperative Complications Following Major Elective Surgery

Association Between Mobilization and Composite Postoperative Complications Following Major Elective Surgery

Probiotic effects of human milk‐derived Lactiplantibacillus plantarum M660 on mice with antibiotic‐associated diarrhoea and constipation

Unleashing the Potential of Gut Microbiota: Cholesterol Reduction Through Microbial Bile Acid Metabolism

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