Genetic effects in the mouse of formaldehyde in combination with adenosine and hydrogen peroxide

Fontignie-Houbrechts, N.; Moutschen-Dahmen, J.; Moutschen-Dahmen, M.; Degraeve, N.; Gloor, H.

doi:10.1016/0165-7992(82)90172-5

Cited by 10 publications

(4 citation statements)

References 12 publications

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“…These high incidences of post implantation deaths in the present study at a dose-dependent manner either as embryonic resorption or death can be correlated to the toxic effects of FA that occur in fetuses during the journey in the oviduct and during organogenesis leading to cytotoxic and teratogenic effects occurring after implantation. These results agree with Fontignie et al who reported that embryo mortality, before and after implantation deaths increased significantly with paternal exposure by intraperitoneal injection of FA in male mice parents [22,23] . Also, Thrasherand Kilburn [5] in their 2001 study on pregnant rats have observed damage to blastomeres, increased rate of embryo degeneration; pre and postimplantation deaths increased by two fold; by inhalation of FA at 0.5 and 1.5mg/m3 4 h/d for 4 months.…”

Section: Discussionsupporting

confidence: 93%

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Assessment of Formalin Teratogenicity on Embryos of Pregnant Albino Rats

Kelada

Al-Kalaa

El-Alkamy

et al. 2019

Egyptian Journal of Histology

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Background: Formaldehyde (FA) is an economically important chemical that is commonly used in the production of industrial, laboratory, household, and cosmetic products. FA is a potential carcinogen and mutagen. Exposure to formaldehyde is common especially among medical and paramedical personnel as it is widely used disinfectant. The exposure becomes maximal and semi-obligatory among workers and personnel of anatomy departments in the different faculties of medicine in a lot of countries and Egypt among; it is the main substance used for cadavers and human parts preservations. Workers and staff of anatomy departments among those with the highest possible formalin exposure with the risk to experience part or most of its possible serious hazardous health effects. This attracts our attention and necessitates a careful study for the possible effects of formalin on the embryos of exposed mothers. Objectives: This study was designed to evaluate the teratogenicity of formaldehyde in experimental animals exposed to FA. Methods: The study included fifty adult female albino Mice, that were divided into five groups ; (Ia): Negative control group received distilled water, (Ib): Positive control: received oral colchicines 2mg/kg /day on gestational days 6-13, Group II, III and IV: received formaldehyde orally in gestational days 6-13 with concentrations 7,14 and 21 mg/kg/day respectively. Pregnant females were sacrificed on 18 th gestational day. The uterine horns were examined for resorption sites, alive or dead fetuses. Extracted fetuses were examined for external developmental abnormalities and stained for skeletal malformations. Results: Decrease in the body weight of the newborns, Increase frequency of abortion and Fetuses mortality and there were some anomalies among the newborn mice which included umbilical hernia, subcutaneous bleeding , ear deformity, delayed ossification of skull bones and Caudal vertebrae were unossified or showed very small ossification centre. Conclusion:The pervious findings suggest that formaldehyde is a teratogenic substance.

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Section: Discussionsupporting

confidence: 93%

“…The decreased ossification of different bones could be due to change in calcium metabolism or decreased calcium and magnesium levels and /or altered calcitonin level in the growing fetus, causing abnormalities in bone development [23] .…”

Section: Discussionmentioning

confidence: 99%

Assessment of Formalin Teratogenicity on Embryos of Pregnant Albino Rats

Kelada

Al-Kalaa

El-Alkamy

et al. 2019

Egyptian Journal of Histology

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“…pregnant mice with various concentrations of formaldehyde and found evidence of DNA breakage and damage and DPC, with more severe effects in the fetus than in the mother [79]. Pre- and post- implantation deaths increased significantly with paternal exposure by intraperitoneal injection [80–81]. In a study of 34 pregnant mice who were orally exposed to formaldehyde, 22 died before analysis was performed; however, teratogenic effects were not observed in the fetuses of the 12 survivors [82].…”

Section: Experimental Animal Studiesmentioning

confidence: 99%

Reproductive and developmental toxicity of formaldehyde: A systematic review

Duong

Steinmaus

McHale

et al. 2011

Mutation Research/Reviews in Mutation Research

257

180

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Formaldehyde, the recently classified carcinogen and ubiquitous environmental contaminant, has long been suspected of causing adverse reproductive and developmental effects, but previous reviews were inconclusive, due in part, to limitations in the design of many of the human population studies. In the current review, we systematically evaluated evidence of an association between formaldehyde exposure and adverse reproductive and developmental effects, in human populations and in vivo animal studies, in the peer-reviewed literature. The mostly retrospective human studies provided evidence of an association of maternal exposure with adverse reproductive and developmental effects. Further assessment of this association by meta-analysis revealed an increased risk of spontaneous abortion (1.76, 95% CI 1.20–2.59, p=0.002) and of all adverse pregnancy outcomes combined (1.54, 95% CI 1.27–1.88, p<0.001), in formaldehyde-exposed women, although differential recall, selection bias, or confounding cannot be ruled out. Evaluation of the animal studies including all routes of exposure, doses and dosing regimens studied, suggested positive associations between formaldehyde exposure and reproductive toxicity, mostly in males. Potential mechanisms underlying formaldehyde-induced reproductive and developmental toxicities, including chromosome and DNA damage (genotoxicity), oxidative stress, altered level and/or function of enzymes, hormones and proteins, apoptosis, toxicogenomic and epigenomic effects (such as DNA methylation), were identified. To clarify these associations, well-designed molecular epidemiologic studies, that include quantitative exposure assessment and diminish confounding factors, should examine both reproductive and developmental outcomes associated with exposure in males and females. Together with mechanistic and animal studies, this will allow us to better understand the systemic effect of formaldehyde exposure.

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“…Efforts to detect formaldehyde-induced DNA-DNA crosslinks within intact cells have been unsuccessful (43,49). Other studies have suggested that formaldehyde mutagenesis might be mediated through reactive by-products resulting from interaction with free amino acids, nucleotide precursors, or hydrogen peroxide (50)(51)(52)(53). This is because induction of genotoxic events in Drosophila, E. coli, and mice may require or be facilitated by concomitant administration of these natural substances.…”

Section: Mechanisms Of Genotoxicitymentioning

confidence: 99%

Contribution of formaldehyde to respiratory cancer.

Nelson¹,

Levine²,

Albert³

et al. 1986

Environ Health Perspect

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This article reviews the available data on the carcinogenicity of formaldehyde from experimental and epidemiologic studies and makes recommendations for further research. Two definitive chronic inhalation bioassays on rodents have demonstrated that formaldehyde produces nasal cancer in rats and mice at 14 ppm and in rats at 6 ppm, which is within the domain of present permissible human exposure (8-hr time-weighted average of 3 ppm, a 5 ppm ceiling, and a 10 ppm short-term exposure limit). Biochemical and physiologic studies in rats have shown that inhaled formaldehyde can depress respiration, inhibit mucociliary clearance, stimulate cell proliferation, and crosslink DNA and protein in the nasal mucosa. No deaths from nasal cancer have been reported in epidemiologic studies of cohorts exposed to formaldehyde, but three case-control studies suggest the possibility of increased risk. Although excesses of lung cancer deaths have been observed in some studies at industrial plants with formaldehyde exposure, uncertainties in interpretation limit the evaluation of these findings. Excess cancers of the brain and of lymphatic and hematopoietic tissues have been reported in certain studies of industrial groups and in most studies of formaldehyde-exposed professionals, but whether these excesses are related to formaldehyde exposure is not known. Several properties of formaldehyde pose unique problems for future research: the mechanisms responsible for its nonlinear response; its probable mechanism of carcinogenic action as a cross-linking agent; its formation in tissues as a normal metabolite; its possible action as a promoter and/or a cocarcinogen; and the importance of glutathione as a host defense at low exposure.

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Genetic effects in the mouse of formaldehyde in combination with adenosine and hydrogen peroxide

Cited by 10 publications

References 12 publications

Assessment of Formalin Teratogenicity on Embryos of Pregnant Albino Rats

Assessment of Formalin Teratogenicity on Embryos of Pregnant Albino Rats

Reproductive and developmental toxicity of formaldehyde: A systematic review

Contribution of formaldehyde to respiratory cancer.

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