Genetic Factors Associated With Recurrent Pregnancy Loss

Kar, Bibhas; B, Linda Catherine

doi:10.15406/ogij.2017.07.00272

Cited by 2 publications

(3 citation statements)

References 39 publications

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“…This is known as chromosomal aneuploidy, the most common spontaneous abortion. (14,15) There were about 50% of aborted fetuses had chromosomal abnormalities caused by nondisjunction. As many as 7,3% of mothers with chromosomal abnormalities experienced repeated abortions in the first trimester.…”

Section: Figure2 Etiology Of Recurrent Pregnancy Lossmentioning

confidence: 99%

“…In addition, paternal chromosomes are also involved, where as many as 2.1% of fathers have chromosomal defects with X-chromosome mosaicism and inversion. (15) Generally, mutations in genes used to maintain a pregnancy are known to result in abortion. However, it can cause oxidative stress, thrombophilic, and immunological disorders resulting in RPL.…”

Section: Figure2 Etiology Of Recurrent Pregnancy Lossmentioning

confidence: 99%

“…In oxidative stress factors, antioxidant levels in RPL patients are generally lower when compared to patients without RPL, where there are normal levels of antioxidants in whole blood and in plasma, whereas in thrombophilic factors it is explained that there is a coagulation disorder. (15) Immune factors associated with miscarriage are categorized as autoimmune factors and alloimmune factors. The autoimmune factor that causes RPL is the synthesis of autoantibodies (antiphospholipid antibodies, antinuclear antibodies, antithyroid antibodies).…”

Section: Figure2 Etiology Of Recurrent Pregnancy Lossmentioning

confidence: 99%

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Predicting Factor of BOH: How to Diagnosed?

Perdana¹,

Fauzia

Rohmansyah

et al. 2022

ijmsci

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Background: Bad obstetric history (BOH) a common complication pregnancy, defined as 3 consecutive pregnancy losses prior 20 weeks from last menstrual period. Case Presentation: A 33 years old woman, G4P1A3 hasn’t feel fetus movement since 2 weeks ago, didn’t experience blood coming out from her vagina or contraction on her stomach. Patient had miscarriage two times. In her first pregnancy, she experienced blood coming out of her vagina, bright red coloured. The ultrasound examination showed no vital signs in fetus and had to terminate her pregnancy with misoprostol. Conclusion: BOH affecting approximately 15% pregnancies. It is unknown whether miscarriage happened during pregnancy with a normal fetus or not. To diagnose recurrent miscarriage, several steps are taken, namely ensuring that all prerequisite conditions for pregnancy are met, ascertaining the type and cause of recurrent miscarriage, dealing with specific management, empirical therapy, and assisted reproductive technology.

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Section: Figure2 Etiology Of Recurrent Pregnancy Lossmentioning

confidence: 99%

Section: Figure2 Etiology Of Recurrent Pregnancy Lossmentioning

confidence: 99%

Section: Figure2 Etiology Of Recurrent Pregnancy Lossmentioning

confidence: 99%

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Predicting Factor of BOH: How to Diagnosed?

Perdana¹,

Fauzia

Rohmansyah

et al. 2022

ijmsci

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Genetic Counselling: the biomedical bridge between molecular diagnosis and precision treatment

Banerjee¹,

Bhattacharjee²

2022

Egypt J Med Hum Genet

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Background Since the development of genomics, we are able to understand backgrounds of differential pathogenicity of metabolic disorders. Molecular diagnosis has become inevitable for metabolic, neuro-psychiatric and genetic disorders due to highly overlapping pathophysiological symptoms. The present lacuna between clinical prescription and molecular diagnosis is very prominent and can only be filled up through experts who can function as the bridge in between. Main body In this present review, the authors tried to focus on the role of genetic counselors in disease diagnosis as well as scopes of disease biology in utilizing the expertise of genetic professional for precision treatments of patients. We summarized four major disease areas, Cancer management, Obstetrics and Gynecology, Newborn Screening and Rare Genetic Disorders, where molecular diagnosis and genetic counseling can highly support the clinicians in precision treatment of the patients. Idiopathic reproductive failures, clinically overlapping neuro-psychiatric disorders, chromosomal aberrations in progressing tumors, rare genetic disorders all the disease areas can find out fruitful intervention when enlightened with molecular diagnosis and genetic counseling. Though, genetic counseling is commonly practiced in intervening reproductive problems, newborn screening and cancer, still the scope of genetic counselor in successfully intervening multiple rare genetic diseases as well as common hereditary life style disorders, remain extremely high. Conclusion The liaison between clinicians and geneticists, specifically clinical prescription and genetic diagnosis is one of the key demands of present age, which can be successfully fulfilled by the genetic counselors. For these reasons, genetic counseling is predicted as the biomedical career of future due to being in the vital position for successful implementation of precision medicine.

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Genetic Factors Associated With Recurrent Pregnancy Loss

Cited by 2 publications

References 39 publications

Predicting Factor of BOH: How to Diagnosed?

Predicting Factor of BOH: How to Diagnosed?

Genetic Counselling: the biomedical bridge between molecular diagnosis and precision treatment

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