Genetic factors predicting response to interferon treatment for viral hepatitis C

Consistent beneficial effects of killer cell immunoglobulin‐like receptor 2DL3 and group 1 human leukocyte antigen‐C following exposure to hepatitis C virus†

“…However, there is a considerable heterogeneity in response to IFN-α and host genetic factors also play a role. 27-29 Moreover, it has also been shown that treatment-induced or enhanced cellular immune responses are important in the outcome of the treatment of HCV infection. 30-32 Successful treatment with IFN-α has been associated with augmented cytotoxicity and up-regulation of activating receptors, implying a normalization of NK cell function.…”

Serum TNF-α, B2M and sIL-2R levels are biological correlates of outcome in adjuvant IFN-α2b treatment of patients with melanoma

“…In addition, as there is evidence that TNF-can decrease before a relapse has occurred, TNF-should be monitored during the duration of IFN-therapy. Nevertheless, at present it is unclear whether patients respond individually with a diVerent cytokine proWle (Starkel 2008). Analyzing cytokine gene polymorphism in melanoma patients undergoing IFN therapy will probably give an explanation.…”