Genetic imbalances in 26 cases of penile squamous cell carcinoma

Alves, Gilda; Heller, Anita; Fiedler, Wolfgang; Campos, Maria Martha; Claussen, Uwe; Ornellas, Antônio Augusto; Liehr, Thomas

doi:10.1002/gcc.1117

Cited by 39 publications

(12 citation statements)

References 9 publications

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“…8 In contrast, the gain of the 8q24 chromosomal band containing MYC is a recurrent finding in PSCC. 9 We focused on the detection of MYC aberrations in all stages of PSCC.…”

Section: Discussionmentioning

confidence: 99%

“…8 Comparative genomic hybridization technique in PSCCs demonstrated frequent copy number gains in 8q24, 16p11-12, 20q11-13, 22q, 19q13 and 5p15 with no clear correlation between tumor grade and chromosome aberrations. 9 MYC is a protooncogene located in the 8q24 chromosome band, encoding a transcription factor with a basic helix-loop-helix leucine zipper protein domain that appears to regulate cellular proliferation, differentiation and apoptosis. In vitro studies indicate that MYC is essential for the proliferation of most cell types.…”

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confidence: 99%

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MYC Copy Number Gains are Associated with Poor Outcome in Penile Squamous Cell Carcinoma

Masferrer

Ferrándiz-Pulido

Lloveras³

et al. 2012

Journal of Urology

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“…8 In contrast, the gain of the 8q24 chromosomal band containing MYC is a recurrent finding in PSCC. 9 We focused on the detection of MYC aberrations in all stages of PSCC.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

MYC Copy Number Gains are Associated with Poor Outcome in Penile Squamous Cell Carcinoma

Masferrer

Ferrándiz-Pulido

Lloveras³

et al. 2012

Journal of Urology

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“…Soufir et al [25] suggested a mutation of p53 gene to have been observed in three of three cases (100%), Levi et al [15] in seven of 21 cases (33%), but both Castern et al [3] and Suzuki et al [27] suggested no mutation of p53 gene was observed. Alves et al [1] presented deletions in 13q21-22 and 4q21-32 on chromosome region and Poetsch et al [20] presented deletions in 2q,6p,8q, 9p, 21q, and 17p13 on chromosome region. For methylation, besides a few, only two literatures discussed PC.…”

Section: Discussionmentioning

confidence: 99%

Frequent epigenetic silencing of the FHIT gene in penile squamous cell carcinomas

et al. 2008

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Methylation of normally unmethylated CpG-rich islands in or near the promoter region has been associated with transcriptional inactivation of tumor-suppressor and tumor-related genes in human cancers. However, so far, only a few studies have searched for DNA methylation in penile carcinoma (PC). On the other hand, human papillomavirus (HPV) has been reported to be associated with the pathogenesis of PC. To elucidate the methylation status of PC and HPV infection, the methylation status of eight genes (DAPK, FHIT, MGMT, p14, p16, RAR-beta, RASSF1A, and RUNX3), the incidences of the HPV status, and the expression of Fhit protein were examined in 25 PCs. The frequencies of methylation were: 28% for DAPK, 92% for FHIT, 20% for MGMT, 4% for p14, 24% for p16, 24% for RAR-beta, 12% for RASSF1A, and 44% for RUNX3. Negative expression of Fhit protein was observed in 22 of the 25 cancers (88%). Among those 22, 20 showed methylation of the FHIT gene. HPV-DNA was detected in three of the 25 cancers (12%). Methylation of FHIT gene was frequently found than HPV infection, therefore methylation of the FHIT gene is suggested to play an important role in the pathogenesis of penile squamous cell carcinoma.

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“…No association to grade and stage was detected. The same authors [85] noted telomerase activity in 85.5% of invasive penile tumors. The possible prognostic value of these findings needs further clarification.…”

Section: Chromosomal Abnormalities and Prognosismentioning

confidence: 88%

“…Alves et al [85] showed that DNA sequence copy-number alterations were detected in penile SCC with distinct similarity to other SCC (oral and esophageal). In 23 tumors that were analyzed, common copy-number gains included 8q24, 16p11-12, 20q11-13, 22q, 19q13 and 5p15.…”

Section: Chromosomal Abnormalities and Prognosismentioning

confidence: 98%

Prognostic factors and biomarkers of penile carcinoma

Lopes

2008

Expert Opinion on Medical Diagnostics

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Penile squamous cell carcinoma (SCC) is a rare malignancy with highest incidence in underdeveloped and developing countries. Oncogenic human papilloma virus (HPV) DNA, mainly types 16 and 18, are found in ∼ 100% of patients with uterine cervix carcinoma. The incidence of this virus in SCC and its variations range from 30.5 to 80%. Despite controversies, contrary to the cervical carcinoma, in the carcinogenesis and disease progression of SCC, HPV-dependent and HPV-independent tumors need to be considered. Lymphadenectomies continue to be the gold standard treatment of lymph node metastases. Undesirable accuracy on staging system methods and high rates of lymphadenectomy complications are the principal objections to these surgical procedures; therefore, the main issue in patients with SCC is to know who should or should not undergo lymphadenectomy. The search for primary tumor anatomopathological and biomarker risk factors for lymph node metastases, such as has occurred in other tumors, may be an important tool to select lymphadenectomies candidates better. Histological subtypes, tumor grade, growth pattern, tumor thickness, lymphatic embolization by neoplasic cells and depth of infiltration have been reported as important prognostic factors for lymph node metastases. In our series, lymphatic vascular permeation, palpable lymph node after primary tumor control (cN stage), pattern of invasion, p53 and PCNA immunoreactivity are independent lymph node metastases risk factors in the multivariate model. It is strongly recommended that patients be concentrated in specialized centers or cancer hospitals and multi-centric prospective studies carried out on tumor markers in this rare disease, in order to stage better lymph node disease and avoid unnecessary surgeries with high morbidity rates.

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Genetic imbalances in 26 cases of penile squamous cell carcinoma

Cited by 39 publications

References 9 publications

MYC Copy Number Gains are Associated with Poor Outcome in Penile Squamous Cell Carcinoma

MYC Copy Number Gains are Associated with Poor Outcome in Penile Squamous Cell Carcinoma

Frequent epigenetic silencing of the FHIT gene in penile squamous cell carcinomas

Prognostic factors and biomarkers of penile carcinoma

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