2008
DOI: 10.1016/j.brainres.2008.08.080
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Genetic increase in brain-derived neurotrophic factor levels enhances learning and memory

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Cited by 58 publications
(41 citation statements)
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“…Measurement of Neurotrophin Levels-Protein levels of BDNF, GDNF, NGF, NT-3, and TGF-␤1 were measured as described (32). The PBS-perfused cerebral cortex described above was excised from each mouse (7-18 weeks old) and homogenized.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Measurement of Neurotrophin Levels-Protein levels of BDNF, GDNF, NGF, NT-3, and TGF-␤1 were measured as described (32). The PBS-perfused cerebral cortex described above was excised from each mouse (7-18 weeks old) and homogenized.…”
Section: Methodsmentioning
confidence: 99%
“…Morris Water Maze (MWM) Test-We conducted the MWM test (33) using modifications as described previously (32). In a 64 ϫ 91 cm-sized pool of opaque water (from a nontoxic agent), a 10 ϫ 10 cm-square-shaped platform was hidden at a fixed position 2 cm under the surface of the water.…”
Section: Methodsmentioning
confidence: 99%
“…BDNF has been shown to promote the differentiation and survival of embryonic hippocampal neurons (Ip et al 1993;Cheng and Mattson 1994;Lindholm et al 1996). In addition to BDNF-mediated neuronal differentiation and neurite outgrowth in the developing brain (Lee et al 2002), BDNF is also known to modulate synaptic plasticity, thereby contributing to learning and memory (Nakajo et al 2008).…”
Section: Discussionmentioning
confidence: 99%
“…For example, BDNF contributes to the formation of long-term potentiation (LTP) (Figurov et al, 1996;Korte et al, 1995) and up-regulates NMDA receptor sensitivity which is required for LTP (Madara and Levine, 2008). Furthermore, it was recently reported that genetic increases in BDNF enhance learning and memory (Nakajo et al, 2008).…”
Section: Introductionmentioning
confidence: 99%