Genetic influences on functional connectivity associated with feedback processing and prediction error: Phase coupling of theta-band oscillations in twins

Demiral, Şükrü Barış; Golosheykin, Simon; Anokhin, Andrey P.

doi:10.1016/j.ijpsycho.2016.12.013

Cited by 6 publications

(4 citation statements)

References 75 publications

(103 reference statements)

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“…ACE models were chosen based on previous work demonstrating that for many similar task-related frontal EEG components (Anokhin et al, 2008; Demiral et al, 2017; Malone et al, 2017), ACE models fit better than other potential twin models, such as ADE non-additive genetic dominance (D) effect models. The magnitude of the influence of each ACE latent variable on a phenotype is estimated by comparing the expected covariance matrix, derived from the known correlations between family members with respect to A (expected twin correlation: MZ = 1, DZ = 0.5), C (MZ and DZ = 1), and E (MZ and DZ = 0), to the observed covariance matrix.…”

Section: Methodsmentioning

confidence: 99%

Testing the effects of adolescent alcohol use on adult conflict-related theta dynamics

Harper

Malone

Iacono

2017

Clinical Neurophysiology

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Objective Adolescent alcohol use (AAU) is associated with brain anomalies, but less is known about long-term neurocognitive effects. Despite theoretical models linking AAU to diminished cognitive control, empirical work testing this relationship with specific cognitive control neural correlates (e.g., prefrontal theta-band EEG dynamics) remains scarce. A longitudinal twin design was used to test the hypothesis that greater AAU is associated with reduced conflict-related EEG theta-band dynamics in adulthood, and to examine the genetic/environmental etiology of this association. Methods In a large (N = 718) population-based prospective twin sample, AAU was assessed at ages 11/14/17. Twins completed a flanker task at age 29 to elicit EEG theta-band medial frontal cortex (MFC) power and medial–dorsal prefrontal cortex (MFC-dPFC) connectivity. Two complementary analytic methods (cotwin control analysis; biometric modeling) were used to disentangle the genetic/shared environmental risk towards AAU from possible alcohol exposure effects on theta dynamics. Results AAU was negatively associated with adult cognitive control-related theta-band MFC power and MFC-dPFC functional connectivity. Genetic influences primarily underlie these associations. Conclusions Findings provide strong evidence that genetic factors underlie the comorbidity between AAU and diminished cognitive control-related theta dynamics in adulthood. Significance Conflict-related theta-band dynamics appear to be candidate brain-based endophenotypes/mechanisms for AAU.

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Section: Methodsmentioning

confidence: 99%

Testing the effects of adolescent alcohol use on adult conflict-related theta dynamics

Harper

Malone

Iacono

2017

Clinical Neurophysiology

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“…Regarding reward-related processing, such as monetary tasks, no studies using EEG or MEG measures were found in FC in alcohol dependence. However, a study carried out in healthy population indicates changes in FC ( 133 ), reflected by increases in theta synchronization between frontal region and mostly parietal areas during the loss condition and greater theta FC within posterior regions during the gain condition. Moreover, this study is carried out in co-twins and they find a genetic heritability of fronto-parietal connectivity in theta during the loss condition, indicating that reward evaluation of negative outcomes could be genetically transmitted.…”

Section: Evidence In Other Neuropsychophysiological Measuresmentioning

confidence: 99%

“…Despite the quite diverse outcomes, there seems to be an agreement upon their role in the brain, and some of them have even been proposed as possible markers of alcohol effects in the brain or as vulnerability markers, such as changes in theta connectivity ( 131 ). In this manner, alterations in FC of theta might indicate changes in the inhibitory neuronal system, related to GABAergic and cholinergic neurotransmission ( 112 ), as well as emotional and motivational processing ( 133 ), whereas beta and alpha FC might reflect supervision and coordination processes involved in brain activation and deactivation systems ( 134 ).…”

Section: Evidence In Other Neuropsychophysiological Measuresmentioning

confidence: 99%

Neuropsychophysiological Measures of Alcohol Dependence: Can We Use EEG in the Clinical Assessment?

et al. 2020

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Addiction management is complex, and it requires a bio-psycho-social perspective, that ought to consider the multiple etiological and developmental factors. Because of this, a large amount of resources has been allocated to assess the vulnerability to dependence, i.e., to identify the processes underlying the transition from substance use to dependence, as well as its course, in order to determine the key points in its prevention, treatment, and recovery. Consequently, knowledge \from neuroscience must be taken into account, which is why different initiatives have emerged with this objective, such as the “Research Domain Criteria” (RDoC), and the “Addiction Neuroclinical Assessment” (ANA). Particularly, neuropsychophysiological measures could be used as markers of cognitive and behavioral attributes or traits in alcohol dependence, and even trace clinical change. In this way, the aim of this narrative review is to provide an overview following ANA clinical framework, to the most robust findings in neuropsychophysiological changes in alcohol dependence, that underlie the main cognitive domains implicated in addiction: incentive salience, negative emotionality, and executive functioning. The most consistent results have been found in event-related potential (ERP) analysis, especially in the P3 component, that could show a wide clinical utility, mainly for the executive functions. The review also shows the usefulness of other components, implicated in affective and substance-related processing (P1, N1, or the late positive potential LPP), as well as event-related oscillations, such as theta power, with a possible use as vulnerability or clinical marker in alcohol dependence. Finally, new tools emerging from psychophysiology research, based on functional connectivity or brain graph analysis could help toward a better understanding of altered circuits in alcohol dependence, as well as communication efficiency and effort during mental operations. This review concludes with an examination of these tools as possible markers in the clinical field and discusses methodological differences, the need for more replicability studies and incipient lines of work. It also uses consistent findings in psychophysiology to draw possible treatment targets and cognitive profiles in alcohol dependence.

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“…We previously showed heritability of brain EEG signals in error monitoring for twins with Mx model [45].…”

Section: Intra-pair Twin Correlations and Genetic Heritability Analysismentioning

confidence: 99%

Blink-induced changes in pupil dynamics are consistent and heritable

Demiral,

Volkow

2024

Preprint

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Pupil size and blink rates are heritable but the extent to which they interact with one another has not been properly investigated. Though changes in pupil size due to eye blinks have been reported, they are considered a pupillary artifact. In this study we used the HCP 7T fMRI dataset with resting state eye-tracking data obtained in monozygous and dizygous twins to assess their heritability and their interactions. For this purpose, we characterized the pupil dilation (positive peak) and constriction (negative peak) that followed blink events, which we describe as blink-induced pupillary response (BIPR). We show that the BIPR is highly consistent with a positive dilatory peak (D-peak) around 500ms and a negative constricting peak (C-peak) around 1s. These patterns were reproducible within- and between-subjects across two time points and differed by vigilance state (vigilant versus drowsy). By comparing BIPR between monozygous and dizygous twins we show that BIPR have a heritable component with significant additive genetic (A) and environmental (E) factors dominating the structural equation models, particularly in the time-domain for both D- and C-peaks and amplitude domain for the C-peak. (a2 between 42–49%). Blink duration, pupil size and blink rate were also found to be highly heritable (a2 up to 62% for pupil size). Our study documents an association between BIPR and wakefulness and indicates that BIPR should not be treated as a coincidental artefact, but part of a larger oculomotor system that we label here as Oculomotor Adaptive System, OAS, that is genetically determined.

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Genetic influences on functional connectivity associated with feedback processing and prediction error: Phase coupling of theta-band oscillations in twins

Cited by 6 publications

References 75 publications

Testing the effects of adolescent alcohol use on adult conflict-related theta dynamics

Testing the effects of adolescent alcohol use on adult conflict-related theta dynamics

Neuropsychophysiological Measures of Alcohol Dependence: Can We Use EEG in the Clinical Assessment?

Blink-induced changes in pupil dynamics are consistent and heritable

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