Genetic Instability in Gastric Epithelial Neoplasias Categorized by the Revised Vienna Classification

Chung, Woo Chul; Jung, Sung Hoon; Lee, Kang Moon; Paik, Chang Nyol; Kwak, Jae Wuk; Jung, Jae Hyun; Yoo, Jin Young; Lee, Min Kyoung; Chung, In‐Sik

doi:10.5009/gnl.2010.4.2.179

Cited by 5 publications

(5 citation statements)

References 46 publications

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“…Some investigators have suggested that the increased microsatellite instability caused by H. pylori infection may improve the prognosis of GC but others have presented conflicting findings. [36][37][38][39] Furthermore, H. pylori infection has been reported to suppress constitutive secretion of the macrophage migration inhibitory factor (MIF), a potential negative prognostic factor associated with the advanced tumor stages and poor patient survival in GC. 40,41 Because CagA, VacA, and BabA mimic and bind to specific receptors or surface molecules on gastric epithelial cells and platelets, anti-CagA, anti-VacA, and anti-BabA antibodies may mediate killing and even suppress metastasis of cancer cells in an autoimmune reaction.…”

Section: Discussionmentioning

confidence: 99%

Activation of CD3⁺ T cells by Helicobacter pylori DNA vaccines in potential immunotherapy of gastric carcinoma

Xue

Mao

Liu

et al. 2019

Cancer Biology & Therapy

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Most of gastric carcinoma (GC) is attributed to infection by Helicobacter pylori (H. pylori) but there is increasing evidence that the positive H. pylori status correlates with better prognosis in GC. The H. pyloriinduced cellular immune response may suppress cancer and in this work, recombinant pcDNA3 plasmids encoding various fragments of H. pylori virulence genes of cagA, vacA and babA are constructed and combined into groups to immunize BALB/c mice. The activated splenic CD3 + T cells are purified and the anticancer effects are investigated in vitro and in vivo. The H. pylori DNA vaccines induce a shift in the response from Th1 to Th2 that mimicks the immune status in patients of GC with chronic H. pylori infection. The stimulated CD3 + T cells inhibit the growth of human GC cells in vitro and adoptive transfusions of the CD3 + T cells suppress the growth of GC xenograft in vivo. The effects may be caused by the larger ratios of infiltrated CD8 + /CD4 + T cells, reduced infiltration of regulatory FOXP3 + T cells, and enhanced apoptosis induced by upregulation of Caspase-9/Caspase-3 and downregulation of Survivin. Our results reveal the potential immunotherapeutic value of H. pylori vaccine-activated CD3 + T cells in those with advanced GC.

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Section: Discussionmentioning

confidence: 99%

Activation of CD3⁺ T cells by Helicobacter pylori DNA vaccines in potential immunotherapy of gastric carcinoma

Xue

Mao

Liu

et al. 2019

Cancer Biology & Therapy

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“…Helicobacter pylori infection is known to be associated with genetic instability leading to MSI-associated premalignant lesions. 21 Different from colorectal cancer, H. pylori infection leads to a deficiency of DNA MMR in gastric epithelial cells, which increases the risks of mutation and cancer. 21 , 22 However, the suppressor pathway related to alterations in the p53, APC, and K-ras genes seems to be more important than the mutator pathway for colorectal carcinogenesis, especially for distal colon and rectal cancers.…”

Section: Discussionmentioning

confidence: 99%

Microsatellite Instability of Gastric and Colorectal Cancers as a Predictor of Synchronous Gastric or Colorectal Neoplasms

et al. 2016

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Background/AimsMicrosatellite instability (MSI) plays a crucial role in gastrointestinal carcinogenesis. The aim of this study was to clarify whether MSI is a useful marker for predicting synchronous gastric and colorectal neoplasms.MethodsConsecutive patients who underwent both esophagogastroduodenoscopy and colonoscopy before the resection of gastric or colorectal cancers were included. MSI was analyzed using two mononucleotide and three dinucleotide markers.ResultsIn total, 434 gastric cancers (372 microsatellite stability [MSS], 21 low incidence of MSI [MSI-L], and 41 high incidence of MSI [MSI-H]) and 162 colorectal cancers (138 MSS, 9 MSI-L, and 15 MSI-H) were included. Patients with MSI gastric cancer had a higher prevalence of synchronous colorectal cancer, colorectal adenoma, and gastric adenoma than those with MSS gastric cancers (4.8% vs 0.5%, p=0.023; 11.3% vs 3.2%, p=0.011; 3.2% vs 1.2%, p=0.00, respectively). The prevalence of synchronous colorectal adenomas was highest in MSI-L gastric cancers (19.0%), compared with MSI-H (7.3%) or MSS (3.2%) gastric cancers (p=0.002). In addition, there were no significant differences in the prevalence rates of synchronous colorectal adenoma among the MSI-H (13.3%), MSI-L (11.1%), and MSS (12.3%) colorectal cancers (p=0.987).ConclusionsThe presence of MSI in gastric cancer may be a predictor of synchronous gastric and colorectal neoplasms, whereas MSI in colorectal cancer is not a predictor of synchronous colorectal adenoma.

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“…From a Western point of view, the final diagnosis rests on examination of the surgical or ESD specimen, because there is some possibility of cancer even if the diagnosis is LGD or HGD [21,23,36,[46][47][48]. Some studies have indicated that LGD and HGD should be treated, because genomic instability may already be present [49][50][51][52]. However, the European guidelines recommend reassessment with biopsy sampling and surveillance at 6-month to 1-year intervals for patients with HGD in the absence of endoscopically defined lesions [8].…”

Section: Discussionmentioning

confidence: 99%

Comparative study of Western and Japanese criteria for biopsy-based diagnosis of gastric epithelial neoplasia

et al. 2014

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Background In Western countries, gastric cancer (GC) is diagnosed when there is histological evidence of invasion into the lamina propria or beyond the submucosa. In Japan and some other countries, however, diagnosis of GC is based on the degree of structural and cytological abnormality of tumor glands. The aim of the present study was to compare the accuracy of the Western and Japanese criteria for diagnosis of GC. Methods The study included 233 consecutive patients with a postoperative diagnosis of submucosal invasive GC who underwent gastrectomy or endoscopic submucosal dissection. All pretreatment biopsy specimens were independently reviewed by two experts in gastrointestinal pathology employing both the Western and Japanese diagnostic criteria. Diagnostic agreement between pretreatment biopsy specimens and the corresponding resected specimens was evaluated, together with the interobserver agreement for each of the criteria. Results On the basis of the Western and Japanese criteria, the pretreatment biopsy diagnosis was noncancerous (including dysplasia) in 44 lesions and 1 lesion, respectively. Diagnostic accuracy based on biopsy was 81.1 % for the Western criteria and 99.5 % for the Japanese criteria (P \ 0.001). Interobserver agreement based on the Western and Japanese criteria was 73.8 % and 96.5 %, respectively (P \ 0.001). Invasion into the submucosa was detected by biopsy in only 25 cases. Conclusions The Japanese criteria are significantly more accurate for pretreatment biopsy diagnosis of GC. The Western criteria could lead to underdiagnosis of a lesion as high-grade dysplasia, even if submucosal invasive cancer is present.

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Genetic Instability in Gastric Epithelial Neoplasias Categorized by the Revised Vienna Classification

Cited by 5 publications

References 46 publications

Activation of CD3⁺ T cells by Helicobacter pylori DNA vaccines in potential immunotherapy of gastric carcinoma

Activation of CD3⁺ T cells by Helicobacter pylori DNA vaccines in potential immunotherapy of gastric carcinoma

Microsatellite Instability of Gastric and Colorectal Cancers as a Predictor of Synchronous Gastric or Colorectal Neoplasms

Comparative study of Western and Japanese criteria for biopsy-based diagnosis of gastric epithelial neoplasia

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Genetic Instability in Gastric Epithelial Neoplasias Categorized by the Revised Vienna Classification

Cited by 5 publications

References 46 publications

Activation of CD3+ T cells by Helicobacter pylori DNA vaccines in potential immunotherapy of gastric carcinoma

Activation of CD3+ T cells by Helicobacter pylori DNA vaccines in potential immunotherapy of gastric carcinoma

Microsatellite Instability of Gastric and Colorectal Cancers as a Predictor of Synchronous Gastric or Colorectal Neoplasms

Comparative study of Western and Japanese criteria for biopsy-based diagnosis of gastric epithelial neoplasia

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Activation of CD3⁺ T cells by Helicobacter pylori DNA vaccines in potential immunotherapy of gastric carcinoma

Activation of CD3⁺ T cells by Helicobacter pylori DNA vaccines in potential immunotherapy of gastric carcinoma