Genetic polymorphism in IL17RA induces susceptibility to Toxoplasma gondii infection in Brazilian pregnant women

Andrade, Joelma Maria de Araújo; Oliveira, Cláudio Bruno Silva de; Meurer, Ywlliane da Silva Rodrigues; Santana, Jéssica Emanuella; Almeida, Yngrid Gleyter Barbosa de; Santos, Priscilla Vilela dos; Souza, Débora Maria Soares de; Costa, Guilherme de Paula; Talvani, André; Palomino, Gustavo Martelli; Freitas, Janaina Cristiana de Oliveira Crispim; Andrade‐Neto, Valter Ferreira de

doi:10.1016/j.actatropica.2020.105594

Cited by 10 publications

(15 citation statements)

References 32 publications

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“…Only one study was published in the predatory journal name ( 43 ). The eligible articles were conducted in China ( 39 ), Iran ( 38 ), Colombia, in collaboration with the United States ( 40 ), India ( 43 ), Egypt ( 41 ), Mexico ( 42 , 44 ) and Brazil ( 25 ).…”

Section: Resultsmentioning

confidence: 99%

“…In all studies, the ELISA diagnostic method was used, and in the study conducted by Goḿez-Chavez et al (42), western blotting was also performed. Furthermore, in some cases, the avidity test was also applied to certify T. gondii acute infection, in which a high result for IgG avidity meant less risk for the fetus (25,39,44).…”

Section: Discussionmentioning

confidence: 99%

“…This syndrome caused by T. gondii is responsible for the systemic activation of the fetal and maternal immune system ( 42 ). Distinct biomarkers work in a Th1/Th2/Th17 balance thought cytokines (IFN-g, TNF, TGF-beta, IL-1beta, Il-10, IL-12, IL-17, IL-18, IL-22, IL-33, etc), chemokines/receptors (CCL2, CCL22, CXCL1, CXCL2, CXCR3, etc), as well as by Toll-like receptors, nucleotide-binding oligomerization domain-like receptors, and inflammasomes (eg.NLRP3, NLRP5 and NAIP1), defining the pathogenesis behind T. gondii infection during pregnancy ( 19 , 24 , 25 , 27 , 35 , 38 , 46 – 48 ). Beyond this, it is also remarkable to highlight the importance of the genetic variability of T. gondii identified in different continents/countries and, how variability can dictate the prognostic of gestation ( 30 – 32 ) .…”

Section: Discussionmentioning

confidence: 99%

“…( 42 ), western blotting was also performed. Furthermore, in some cases, the avidity test was also applied to certify T. gondii acute infection, in which a high result for IgG avidity meant less risk for the fetus ( 25 , 39 , 44 ).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, not only IL-10, but also IL-22, act as regulatory cytokines suppressing part of T. gondii-induced inflammation, while IL-33 exerts dual proinflammatory and regulatory functions. IL-33 can improve CCL2 expression with recruitment of CCR2+ monocytes, but it can amplify Th2 response with production of IL-10 and IL-22 by M2 macrophages and Th-17-cells, respectively which, in turn, activates Treg cells (23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

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The imbalance in the relationship between inflammatory and regulatory cytokines during gestational toxoplasmosis can be harmful to fetuses: A systematic review

Santos

Toledo²,

Souza³

et al. 2023

Front. Immunol.

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ObjectiveTo evaluate the available information on inflammatory and regulatory plasma mediators in pregnant women (PW) diagnosed with toxoplasmosis. Source: The PubMed, Embase, Scopus, and Lilacs databases were evaluated until October 2022. Study eligibility criteria: This review was carried out following the PRISMA and registered on the PROSPERO platform (CRD42020203951). Studies that reported inflammatory mediators in PW with toxoplasmosis were considered.Evaluation methodsAfter excluding duplicate articles, two authors independently carried out the process of title and abstract exclusion, and a third resolved disagreements when necessary. The full text was evaluated to detect related articles. The extraction table was built from the following data: Author, year of publication, journal name and impact factors, country, study design, number of gestations and maternal age (years), gestational period, diagnosis of toxoplasmosis, levels of inflammatory markers, laboratory tests, and clinical significance. Methodological quality was assessed using Joanna Briggs Institute tools.ResultsOf the 1,024 studies reported, only eight were included. Of the 868 PW included in this review, 20.2% were IgM+/IgG- and 50.8% were IgM-/IgG+ to T. gondii, and 29.0% uninfected. Infected PW presented higher plasma levels ofIL-5, IL-6, IL-8, IL-17, CCL5, and IL-10. Regarding the methodological quality, four studies obtained high quality. Data from this review pointed out the maintenance of the inflammatory pattern during pregnancy with a closely related to the parasite.ConclusionImmune status in PW defined the course of the T. gondii infection, where the equilibrium between inflammatory and regulatory cytokines mitigated the harmful placenta and fetus effects.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD420203951.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The imbalance in the relationship between inflammatory and regulatory cytokines during gestational toxoplasmosis can be harmful to fetuses: A systematic review

Santos

Toledo²,

Souza³

et al. 2023

Front. Immunol.

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Association of polymorphism of IL‐17A, IL‐17F, and IL‐6 with Toxoplasma gondii infection susceptibility in HIV/AIDS patients in Shiraz, southern Iran

Nejabat,

Heydari,

Motamedifar

et al. 2024

Immunity Inflam & Disease

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IntroductionToxoplasma gondii infection is considered as one of the most important opportunistic infections and cause of death in HIV patients.MethodsIn this cross‐sectional study, 334 HIV positive patients were included. The molecular test was performed by the restriction fragment length polymorphism–polymerase chain reaction method. Allelic frequency, haplotype analyses, and linkage disequilibrium were calculated. The odds ratio was calculated. The linear regression model was used to analysis of interleukin (IL)‐17A, IL‐17F, and IL‐6 single‐nucleotide polymorphism genotypes in HIV patients with and without toxoplasmosis.ResultsIn total, 95 tested'patients (28.4%) were positive for toxoplasmosis. The risk of toxoplasma infection in the current study did not correlate with IL‐17 and IL‐6 polymorphism and the risk of contracting toxoplasma was also not significantly correlated in this study. There was no association between the frequency of alleles and the risk of toxoplasma infection in IL‐17 haplotype analysis.ConclusionThe findings of this study revealed that there were significant differences in the serum levels of IL‐6 and IL‐17A, but not IL‐17F, between the case and control groups in various genetic models. However, these polymorphisms did not show a significant relationship with toxoplasma infection in HIV‐positive patients. This study represents the first investigation in Iran to explore the role of IL‐6 and IL‐17 polymorphisms in toxoplasma infection among HIV‐positive patients.

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TNFα rs1799964 TT genotype may be a susceptibility factor for vertical transmission of Toxoplasma gondii and clinical signs in newborns from pregnant women with acute toxoplasmosis

et al. 2022

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Genetic polymorphism in IL17RA induces susceptibility to Toxoplasma gondii infection in Brazilian pregnant women

Cited by 10 publications

References 32 publications

The imbalance in the relationship between inflammatory and regulatory cytokines during gestational toxoplasmosis can be harmful to fetuses: A systematic review

The imbalance in the relationship between inflammatory and regulatory cytokines during gestational toxoplasmosis can be harmful to fetuses: A systematic review

Association of polymorphism of IL‐17A, IL‐17F, and IL‐6 with Toxoplasma gondii infection susceptibility in HIV/AIDS patients in Shiraz, southern Iran

TNFα rs1799964 TT genotype may be a susceptibility factor for vertical transmission of Toxoplasma gondii and clinical signs in newborns from pregnant women with acute toxoplasmosis

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