Genetic polymorphism of the RORC, BGH, BGHR, LEP, LEPR genes in Russian hornless cattle breed

Gorlov, I.F.; Sulimova, G. E.; Перчун, А. В.; Slozhenkina, M I

doi:10.22616/erdev2017.16.n038

Cited by 3 publications

(1 citation statement)

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“…Studies have been revealed that leptin acts via leptin receptor, regulating the satiety and fat deposition [49,50]. To date, LEPR has been widely reported to be related to meat, milk, reproduction, and growth traits in cattle [51][52][53][54][55]. We detected two non-synonymous mutations (rs43347904, g.79,817,216: G > A, exon3, p.S6F; rs43347906, g.79,817,216: C > A, exon4, p.V35L) within the LEPR gene.…”

Section: Discussionmentioning

confidence: 99%

Whole genome sequencing of simmental cattle for SNP and CNV discovery

et al. 2023

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Backgroud The single nucleotide polymorphisms (SNPs) and copy number variations (CNVs) are two major genomic variants, which play crucial roles in evolutionary and phenotypic diversity. Results In this study, we performed a comprehensive analysis to explore the genetic variations (SNPs and CNVs) of high sperm motility (HSM) and poor sperm motility (PSM) Simmental bulls using the high-coverage (25×) short-read next generation sequencing and single-molecule long reads sequencing data. A total of ~ 15 million SNPs and 2,944 CNV regions (CNVRs) were detected in Simmental bulls, and a set of positive selected genes (PSGs) and CNVRs were found to be overlapped with quantitative trait loci (QTLs) involving immunity, muscle development, reproduction, etc. In addition, we detected two new variants in LEPR, which may be related to the artificial breeding to improve important economic traits. Moreover, a set of genes and pathways functionally related to male fertility were identified. Remarkably, a CNV on SPAG16 (chr2:101,427,468 − 101,429,883) was completely deleted in all poor sperm motility (PSM) bulls and half of the bulls in high sperm motility (HSM), which may play a crucial role in the bull-fertility. Conclusions In conclusion, this study provides a valuable genetic variation resource for the cattle breeding and selection programs.

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Section: Discussionmentioning

confidence: 99%

Whole genome sequencing of simmental cattle for SNP and CNV discovery

et al. 2023

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Productivity and biological value of milk of cows of various eco-genetic types

Горлов

Slozhenkina

Mosolova

et al. 2019

IOP Conf. Ser.: Earth Environ. Sci.

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The article gives comparative characteristics of the quality indicators of dairy raw materials obtained from Holstein first-calf heifers delivered to the Volgograd region of Russia from different countries. The research study consisted in processing the data of qualitative and quantitative indices of the cow’s milk production and assessing the nutritional and biological parameters of milk according to current standards. Differences on productivity, in the nutritional and biological values of milk depending on the ecological and genetic types of animals have been revealed. In terms of the milk yield for 305 days of lactation, the research has established the superiority of animals of American selection compared with ones of German, Danish and Australian selection by 100 kg, 600 kg and 620 kg, respectively. The cows of German selection were registered to have the highest content of the weight fraction of milk fat, i.e., 4.01%. Australian Holstein heifers had the highest weight fraction of milk protein (3.24%) and amino acids (valine, isoleucine, leucine, lysine, methionine, tryptophan, phenylalanine, aspartic acid, cystine, arginine and histidine). Animals of Danish Holstein breed were noted for a higher content of macro- and microelements, i.e., calcium, magnesium, zinc, manganese, iodine and silicon. For animals of Danish and American selections, some activities to increase the weight fraction of milk protein have been recommended to perform.

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